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Animal StudyEx VivoHighlighted

Degradation products of magnesium implant synergistically enhance bone regeneration: Unraveling the roles of hydrogen gas and alkaline environment

MHID-4421003PMID: 398164752025Bioactive Materials

Yuanming An, Haozhi Zhang, Shi’an Zhang, Yuantao Zhang, Lizhen Zheng, Xin Chen, et al.

Biodegradable magnesium (Mg) implant generally provides temporary fracture fixation and facilitates bone regeneration. However, the exact effects of generated Mg ions (Mg2+), hydrogen gas (H2), and hydroxide ions (OH-) by Mg degradation on enhancing fracture healing are not fully understood. Here we investigate the in vivo degradation of Mg intramedullary nail (Mg-IMN), revealing the generation of

Animal StudyHighlighted

Effects of Hydrogen-Rich Water on Interleukin-1β, Number of Osteoclasts and Osteoblasts in Streptozotocin-induced Diabetic Rats with Orthodontic Tooth Movement

MHID-70633602023The Indonesian Biomedical Journal

Lina Hadi, Albert Manggading Hutapea, Florenly

BACKGROUND: Orthodontic tooth movement (OTM) may increase the risk of treatment-related complications for some diabetes mellitus (DM) patients. Hydrogen-rich water (HRW) has been demonstrated in many studies to reduce oxidative stress and cell damage. This study aimed to examine the levels of interleukin (IL)-1β, blood glucose level, body weight, tooth displacement, and population of osteoclasts a

HypothesisHighlighted

Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw

MHID-5411216PMID: 265088672015Therapeutics and Clinical Risk Management

Yuanli Chen, Chunlin Zong, Yuxuan Guo, Lei Tian

Hydrogen, a therapeutic medical gas, can exert antioxidant activity via selectively reducing cytotoxic reactive oxygen species such as hydroxyl radicals. Hydrogen-rich saline is an alternative form of molecular hydrogen that has been widely used in many studies, including metabolic syndrome, cerebral, hepatic, myocardial ischemia/reperfusion, and liver injuries with obstructive jaundice, with bene