Observational StudyHighlighted
MHID-67657942026medRxiv
Yuusuke Harada, Michiko Miyakawa
Background: Falls among older adults are a leading cause of fractures, loss of independence, and need for long-term care. Community salons in Japan promote social participation and health activities among older adults. Hydrogen-rich water is widely used as a health product, but evidence in community settings remains limited.
Methods: We conducted a prospective observational study among 48 communit
Clinical Trial
MHID-14786562024Current Developments in Nutrition
Sonja Baltic, Nikola Todorovic, Marijana Ranisavljev, Dragana Zanini, David Nedeljkovic, Darinka Korovljev, et al.
Objectives: Molecular hydrogen (H2) and pyrroloquinoline quinone (PQQ) have been suggested to activate metabolic pathways associated with cognition. No human studies have assessed the efficacy of this nutritional combination in the clinical context of mild cognitive impairment (MCI). The primary objective of this randomized placebo-controlled trial was to evaluate the effects of a six-week suppleme
Clinical TrialHighlighted
MHID-7984305PMID: 389082962024The Journal of Nutrition, Health and Aging
Sonja Baltic, David Nedeljkovic, Nikola Todorovic, Marijana Ranisavljev, Darinka Korovljev, Jelena Cvejic, et al.
Objectives: To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment.
Design: A parallel-group, randomized, placebo-controlled, double-blind experimental design, maintaining a 1:1 allocation ratio between the experimental group (
Animal StudyHighlighted
MHID-65602132024
Yuxi Wei
Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent upper airway collapse during sleep, leading to chronic intermittent hypoxia (CIH) that can cause oxidative stress and chronic inflammation that lead to cardiovascular disease (CVD). Although continuous positive airway pressure (CPAP) treatment is the gold standard for OSA treatment, it has little or no benefit in reduc
Literature ReviewHighlighted
MHID-5381032PMID: 369788842023Antioxidants
Mikhail Yu. Artamonov, Andrew K. Martusevich, Felix A. Pyatakovich, Inessa A. Minenko, Sergei V. Dlin, Tyler W. LeBaron
It is known that molecular hydrogen is a relatively stable, ubiquitous gas that is a minor component of the atmosphere. At the same time, in recent decades molecular hydrogen has been shown to have diverse biological effects. By the end of 2022, more than 2000 articles have been published in the field of hydrogen medicine, many of which are original studies. Despite the existence of several review
Chemical/Physicochemical StudyHypothesisHighlighted
MHID-10655712023Aging Pathobiology and Therapeutics
Shigeo Ohta
Oxidative stress is one of the major causes of most age-dependent neurodegenerative disorders. Neurons accumulate oxidative damage over time due to post-mitotic cells. Thus, modulation of oxidative stress is essential to overcome these disorders. Molecular hydrogen (H2) has great potential for treating various diseases and improving quality of life by exerting multiple functions including anti-oxi
Clinical TrialHighlighted
MHID-1277179PMID: 373719712023Antioxidants
Md. Habibur Rahman, Johny Bajgai, Subham Sharma, Eun-Sook Jeong, Seong Hoon Goh, Yeon-Gyu Jang, et al.
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer’s disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants, including those who dropped out (5%), were screened and enrolled. The selected
Literature ReviewHighlighted
MHID-6539221PMID: 372378542023Antioxidants
Md. Habibur Rahman, Eun-Sook Jeong, Hae Sun You, Cheol-Su Kim, Kyu-Jae Lee
Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. OS plays a crucial role in the dev
Clinical TrialHighlighted
MHID-0848980PMID: 366757282022Journal of Personalized Medicine
Hua Lin, Jian Du, Zhigang Tian, Yonghao Yu, Yan Cui, Keliang Xie
Purpose: Postoperative delirium is a state of acute brain dysfunction characterized by fluctuating mental status that affects millions of patients each year. We used prophylactic inhalation of hydrogen gas in elderly patients undergoing elective surgery to compare their occurrence of postoperative delirium with that of controls.
Methods: A total of 184 patients aged ≥65 years were enrolled and ran
Literature ReviewSystematic Review
MHID-8761287PMID: 357430352022International Journal of Molecular Sciences
Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar
Currently, there is a lot of public interest in naturally occurring substances with medicinal properties that are minimally toxic, readily available and have an impact on health. Over the past decade, molecular hydrogen has gained the attention of both preclinical and clinical researchers. The death of pyramidal neurons in especially the CA1 area of the hippocampus, increased permeability of the b
Clinical TrialHighlighted
MHID-1269854PMID: 362782212022Frontiers in Pharmacology
Boyan Liu, Xue Jiang, Yunbo Xie, Xiubin Jia, Jiashuo Zhang, Yazhuo Xue, et al.
Objective: To explore the effect of a low-dose hydrogen–oxygen (H2-O2) mixture inhalation in midlife/older adults with hypertension.
Methods: This randomized, placebo-controlled trial included 60 participants with hypertension aged 50–70 years who were randomly divided into Air group (inhaled placebo air) or H2-O2 group [inhaled H2-O2 mixture (66% H2/33% O2)]. Participants in both groups were tre
Literature Review
MHID-1010920PMID: 353402182022Oxidative Medicine and Cellular Longevity
Zhiling Fu, Jin Zhang, Yan Zhang
Ageing is a physiological process of progressive decline in the organism function over time. It affects every organ in the body and is a significant risk for chronic diseases. Molecular hydrogen has therapeutic and preventive effects on various organs. It has antioxidative properties as it directly neutralizes hydroxyl radicals and reduces peroxynitrite level. It also activates Nrf2 and HO-1, which r
Literature Review
MHID-5326803PMID: 349874192021Frontiers in Physiology
Yan Tian, Yafang Zhang, Yu Wang, Yunxi Chen, Weiping Fan, Jianjun Zhou, et al.
Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2 inhalation has the therapeutic effects in many animal studies and clinical trials, and its application is recommended in the novel coronavirus pneumonia treatment guidelines in China recently. H2 has a relatively small molecular mass, which helps it quickly spread and penetrate cell membranes to exert a wide range
Literature ReviewHypothesis
MHID-1633113PMID: 321896692020Medical Gas Research
Shin-ichi Hirano, Yusuke Ichikawa, Ryosuke Kurokawa, Yoshiyasu Takefuji, Fumitake Satoh
It has been revealed that the cause of senescence and diseases is associated with the reactive oxygen species “hydroxyl radicals” (·OH). Se- nescence and diseases may be overcome as long as we can scavenge •OH mostly produced in mitochondria. It is one and only one “molecular hydrogen” (H2) that can both penetrate into the mitochondria and scavenge the •OH. The H2 in the body can function in disea
Clinical TrialAnimal StudyHighlighted
MHID-5385411PMID: 291106152018Current Alzheimer Research
Kiyomi Nishimaki, Takashi Asada, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, et al.
Background: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant.
Objective: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI
Literature Review
MHID-3874815PMID: 292542782017Oncotarget
Li Ge, Ming Yang, Na-Na Yang, Xin-Xin Yin, Wen-Gang Song
Since the 2007 discovery that molecular hydrogen (H2) has selective antioxidant properties, multiple studies have shown that H2 has beneficial effects in diverse animal models and human disease. This review discusses H2 biological effects and potential mechanisms of action in various diseases, including metabolic syndrome, organ injury, and cancer; describes effective H2 delivery approaches; and s
In VitroHighlighted
MHID-1014265PMID: 286201982017Scientific Reports
Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Jui-Lin Liang, Jian-He Lu, Chia-Jung Yen, et al.
Based on the oxidative stress theory, aging derives from the accumulation of oxidized proteins induced by reactive oxygen species (ROS) in the cytoplasm. Hydrogen peroxide (H2O2) elicits ROS that induces skin aging through oxidation of proteins, forming disulfide bridges with cysteine or methionine sulfhydryl groups. Decreased Ca2+ signaling is observed in aged cells, probably secondary to the for
Literature ReviewHighlighted
MHID-7479916PMID: 264839532015Medical Gas Research
Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. I
Literature Review
MHID-2828070PMID: 238595552013Current Pharmaceutical Design
Toru Ishibashi
Rheumatoid arthritis (RA) is a chronic inflammatory disease in which the progressive destruction of joint causes morbidity. It is also associated with an increased risk of atherosclerosis, which can result in cardiovascular disease and mortality. The therapeutic goal is to control the systemic inflammation to obtain not only the remission of symptoms, but also improve general state of health. Alth
Clinical TrialObservational Study
MHID-7186474PMID: 230310792012Medical Gas Research
Toru Ishibashi, Bunpei Sato, Mariko Rikitake, Tomoki Seo, Ryosuke Kurokawa, Yuichi Hara, et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in the pathogenesis of RA. Recently, molecular hydrogen (H2) was demonstrated to be a selective scavenger for the hydroxyl radical. Also, the method to prepare water containing extrem
