In SilicoHypothesisHighlighted
MHID-3775261PMID: 398291632025Medical Gas Research
Grace Russell
Hydrogen (H2), the simplest and most ubiquitous molecule in the universe, has garnered significant scientific interest over the past two decades because of its potential as an effective antioxidant and anti-inflammatory agent. Traditionally considered inert, H2 is now being re-evaluated for its unique bioactive properties. H2 selectively neutralizes reactive oxygen and nitrogen species, mitigating
Animal StudyHighlighted
MHID-5834617PMID: 398578172025Biomedicines
Masaki Shibuya, Masafumi Fujinaka, Mako Yonezawa, Natsumi Nishimura, Hitoshi Uchinoumi, Hiroshi Sunahara, et al.
Background: Hydrogen gas (H2) has been shown to be effective in the treatment of various clinical conditions, from acute illnesses to chronic illnesses. However, its clinical indications and the corresponding appropriate hydrogen delivery methods have yet to be determined. This is due to the fact that the pharmacokinetics and pharmacodynamics of hydrogen in each delivery method have not been exper
Literature Review
MHID-3242181PMID: 405693542025Molecular Biology Reports
Yong Ye, Zi-hang Yu, Liang Nie, Bin Lu, Guo Mu
Pyroptosis, a highly inflammatory programmed cell death pathway, drives pathogenesis in numerous diseases through gasdermin-mediated membrane pore formation and massive cytokine release. While conventional anti-inflammatory therapies show limited efficacy, hydrogen emerges as a novel therapeutic agent with unique pyroptosis-regulatory capabilities. This review establishes a comprehensive mechanist
Animal StudyIn VitroHighlighted
MHID-8939519PMID: 413302172025Redox Biology
Shuto Negishi, Mikako Ito, Tomoya Hasegawa, Hikaru Otake, Bisei Ohkawara, Akio Masuda, et al.
The mechanisms underlying the biomedical effects of molecular hydrogen (H2) remain poorly understood and
are often attributed to its selective reduction of hydroxyl radicals, based on the long-held notion that H2 is
biologically inert. We demonstrate that H2 is biologically active, specifically targeting the Rieske iron-sulfur
protein (RISP). We first observed that H2 induces the mitochondrial unf
Chemical/Physicochemical Study
MHID-03629032024Molecular Hydrogen in Health and Disease
Katarína Valachová, Branislav Kura, Jan Slezak, Mojmír Mach, Ladislav Šoltés
Molecular hydrogen is well-known for its antioxidative and antiinflammatory properties in numerous in vitro and in vivo experiments. High-molar-mass hyaluronan (HMM HA), a natural polysaccharide present in tissues of all vertebrates, was used as a marker of the polysaccharide degradation by reactive oxygen species. The radical scavenging capacity of various sources of molecular hydrogen dissolved
Literature ReviewHighlighted
MHID-9169500PMID: 327679252021Current Pharmaceutical Design
Shigeo Ohta
Molecular hydrogen (H2) was long regarded as non-functional in mammalian cells. We overturned the concept by demonstrating that H2 exhibits antioxidant effects and protects cells against oxidative stress. Subsequently, it has been revealed that H2 has multiple functions in addition to antioxidant effects, including anti-inflammatory, anti-allergic functions, and as cell death and autophagy regulat
Literature ReviewMeta-Analysis
MHID-7985788PMID: 328266282020Current Opinion in Anesthesiology
Zhen Wang, Guolin Wang, Keliang Xie
Purpose of review: The current systematic review summarizes recent, basic clinical achievements regarding the neuroprotective effects of molecular hydrogen in distinct central nervous system conditions.
Recent findings: Perioperative neuroprotection remains a major topic of clinical anesthesia. Various gaseous molecules have previously been explored as a feasible therapeutic option in neurologica
Animal StudyHighlighted
MHID-61354972014Scientific Reports
Chi Liu, Ryosuke Kurokawa, Masayuki Fujino, Shinichi Hirano, Bunpei Sato, Xiao-Kang Li
Hydrogen exerts beneficial effects in disease animal models of ischemia-reperfusion injury as well as inflammatory and neurological disease. Additionally, molecular hydrogen is useful for various novel medical and therapeutic applications in the clinical setting. In the present study, the hydrogen concentration in rat blood and tissue was estimated. Wistar rats were orally administered hydrogen su
