Animal StudyIn VitroEx VivoHighlightedHydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosisMHID-9370665PMID: 404119852025BiomaterialsYuanming An, Lizhen Zheng, Shi’an Zhang, Haozhi Zhang, Yuantao Zhang, Hongwei Shao, et al.Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing SAON model). Here we find that HRW treatment significantly reduces osteocyte apoptosis, improves deterio
Animal StudyProtective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosisMHID-6821344PMID: 281483012017BMC Musculoskeletal DisordersJia Li, Zhaogang Ge, Lihong Fan, Kunzheng WangBackground: The objective of this study was to investigate the protective effects of molecular hydrogen, a novel and selective antioxidant, on steroid-induced osteonecrosis (ON) in a rabbit model. Methods: Sixty rabbits were randomly divided into two groups (model group and hydrogen group). Osteonecrosis was induced according to an established protocol of steroid-induced ON. Rabbits in the hydrog
