Animal StudyHighlighted
MHID-7407969PMID: 195968252009Experimental Biology and Medicine
QIANG SUN, ZHIMIN KANG, JIANMEI CAI, WENWU LIU, YUN LIU, John H Zhang, et al.
Protective effect of hydrogen (H2) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min occlu
Animal StudyHighlighted
MHID-1488636PMID: 192522952009Biological & Pharmaceutical Bulletin
Kyu Jae LEE, Dan JIN, Byung Soo CHANG, Yung Chien TENG, Dong Heui KIM
Electrolyzed reduced water (ERW) is widely used for drinking by people in Asia. The purpose of this study was to examine the immunological effect of ERW on the immunity of animals by supplying ERW to C57BL/6 mice infected with Echinostoma hortense metacercariae. In the non-infected groups, interleukin (IL)-4 (p0.001), IL-5, IL-10, IL-1b, tumor necrosis factor (TNF)-a and immunoglobulin (Ig) A exp
Animal StudyHighlighted
MHID-8852067PMID: 197896282009PLoS ONE
Kyota Fujita, Toshihiro Seike, Noriko Yutsudo, Mizuki Ohno, Hidetaka Yamada, Hiroo Yamaguchi, et al.
It has been shown that molecular hydrogen (H2) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson’s disease (PD). Here, we show that drinking H2-containing water significantly reduced the loss of dopaminergic neurons in PD model mice using both acute and chronic adm
MHID-1199398PMID: 197660972009Biochemical and biophysical research communications
Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, et al.
Molecular hydrogen ameliorates oxidative stress-associated diseases in animal models. We found that oral intake of hydrogen-rich water abolishes an immediate-type allergic reaction in mice. Using rat RBL-2H3 mast cells, we demonstrated that hydrogen attenuates phosphorylation of the FcepsilonRI-associated Lyn and its downstream signal transduction, which subsequently inhibits the NADPH oxidase act
Animal StudyHighlighted
MHID-3088793PMID: 193565982009Neuroscience Letters
Yuan Fu, Mikako Ito, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, et al.
Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but
not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen
has been reported to prevent or ameliorate eight diseases in rodents and one in human
associated with oxidative stress. In Parkinson’s disease, mitochondrial dysfunction and
the associated oxidative stress are major causes of dopam
Animal StudyIn VitroHighlighted
MHID-5929908PMID: 191486452009Cancer Chemotherapy and Pharmacology
Naomi Nakashima-Kamimura, Takashi Mori, Ikuroh Ohsawa, Sadamitsu Asoh, Shigeo Ohta
Purpose: Cisplatin is a widely used anti-cancer drug in the treatment of a wide range of tumors; however, its application is limited by nephrotoxicity, which is affected by oxidative stress. We have reported that molecular hydrogen (H(2)) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688-694, 2007). Here we show that hydrogen efficiently mitigates the side effects of cisplatin by r
Animal StudyHighlighted
MHID-6761448PMID: 185630582009Neuropsychopharmacology
Kazufumi Nagata, Naomi Nakashima-Kamimura, Toshio Mikami, Ikuroh Ohsawa, Shigeo Ohta
We have reported that hydrogen (H2) acts as an efficient antioxidant by gaseous rapid diffusion. When water saturated with hydrogen (hydrogen water) was placed into the stomach of a rat, hydrogen was detected at several mM level in blood. Because hydrogen gas is unsuitable for continuous consumption, we investigated using mice whether drinking hydrogen water ad libitum, instead of inhaling hydroge
