Animal StudyHighlighted
MHID-1117942PMID: 251770312014Biological & Pharmaceutical Bulletin
Yang-Suk Yoon, Ma. Easter Joy Villarosa Sajo, Rosa Mistica Coles Ignacio, Soo-Ki Kim, Cheol-Su Kim, Kyu-Jae Lee
Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying al- lergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we in- vestigated the effect of drinking hydrogen water (HW) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical
Animal StudyIn VitroHighlighted
MHID-0826156PMID: 246851142014CNS Neuroscience & Therapeutics
Fang-Ting Liu, Sheng-Ming Xu, Zheng-Hua Xiang, Xiang-Nan Li, Jian Li, Hong-Bin Yuan, et al.
Aims: Spinal cord injury (SCI) can induce excessive astrocyte activation. Hydrogen has been deemed as a novel antioxidant. We investigated whether molecular hydrogen could act as an antiastrogliosis agent during SCI and oxidative injury in experimental rats and cultured astrocytes. Methods: Hydrogen-rich saline (HS, 8 mL/kg, i.p.) was injected every 12 h after SCI in rats. The expression of STAT3,
MHID-7628583PMID: 232733312014The Journal of dermatological treatment
Mei K, Zhao S, Qian L, Li B, Ni J, Cai J.
Background: Radiation therapy produced unwanted side effect on normal tissues, such as radiodermatitis. Hydrogen was previously shown capable of radiation protective in both animals and cell cultures. The effect of hydrogen was now to be investigated on radiation-induced cutaneous.
Objective: Development of dermatitis is a frequent side effect of radiotherapy of patients with head-and-neck cancer
Chemical/Physicochemical Study
MHID-6682168PMID: 250864382014Free Radical Biology and Medicine
Jelle Penders, Reinhard Kissner, Willem H. Koppenol
H2 has been suggested to act as an antioxidant when administered just before the reperfusion phase of induced oxidative stress. These effects have been reported, for example, for the heart, brain, and liver. It is hypothesized that this beneficial effect may be due to selective scavenging of HO⋅ and ONOOH by H2. The reaction of H2 with HO⋅ has been studied by pulse radiolysis in the past and is too
MHID-4206971PMID: 251215572014Transplantation
Noda K, Shigemura N, Tanaka Y, Bhama J, D'Cunha J, Kobayashi H, et al.
Background: Although the benefits of ex vivo lung perfusion (EVLP) have been globally advocated, the potentially deleterious effects of applying EVLP, in particular activation of proinflammatory cascades and alteration of metabolic profiles, are rarely discussed. This study examined proinflammatory events and metabolic profiles in lung grafts on EVLP and tested whether preconditioning lung grafts
Literature Review
MHID-0477754PMID: 247690812014Pharmacology & Therapeutics
Shigeo Ohta
Molecular hydrogen (H2) has been accepted to be an inert and nonfunctional molecule in our body. We have turned this concept by demonstrating that H2 reacts with strong oxidants such as hydroxyl radical in cells, and proposed its potential for preventive and therapeutic applications. H2 has a number of advantages exhibiting extensive effects: H2 rapidly diffuses into tissues and cells, and it is m
Literature ReviewHighlighted
MHID-8734083PMID: 342834352014Journal of Neurological Disorders
Mami Noda, Kyota Fujita, Ikuroh Ohsawa, Masafumi Ito, Kinji Ohno
Molecular hydrogen (H2) has been reported to be effective for a variety of disorders and its effect has been
ascribed to a selective scavenge of hydroxyl radicals (•OH) at the beginning. Consumption of H2 was either by
inhalation, drinking H2-containing water (H2 water), or infusion of H2-containing saline. Among various disorders,
animal model of ischemic injury and Parkinson’s disease showed sig
Animal StudyHighlighted
MHID-4606624PMID: 245091622014Free Radical Biology and Medicine
Yukio Mano, Tomomi Kotani, Mikako Ito, Taku Nagai, Yuko Ichinohashi, Kiyofumi Yamada, et al.
Molecular hydrogen (H2) scavenges hydroxyl radicals. Recently, H2 has been reported to prevent a variety of diseases associated with oxidative stress in model systems and in humans. Here, we studied the effects of H2 on rat fetal hippocampal damage caused by ischemia and reperfusion (IR) on day 16 of pregnancy with the transient occlusion of the bilateral utero-ovarian arteries. Starting 2 days be
Literature ReviewAnimal StudyIn VitroHighlighted
MHID-45285932014European Journal of Neurodegenerative Diseases
Mami Noda, M. Ito, I. Ohsawa, K. Ohno
A new medical gas, molecular hydrogen (H2), has been reported to be effective for a variety of disorders and clinical trials have shown promising results. Though the precise mechanism is still unknown, it is obvious that H2 has multiple effects. The first prominent effect of H2 was as antioxidant or reactive oxygen species (ROS)-scavenger, though it blocks only hydroxyl radicals (•OH), which are t
Animal StudyHighlighted
MHID-5761446PMID: 246182602014Journal of Cellular and Molecular Medicine
Sanhu Zhao, Yanyong Yang, Wen Liu, Zhiqiang Xuan, Shouming Wu, Shunfei Yu, et al.
Recent studies showed that hydrogen can be used as an effective radioprotective agent through scavenging free radicals. This study was under-
taken to evaluate the radioprotective effects of hydrogen on immune system in mice. H2 was dissolved in physiological saline using an apparatus
produced by our department. Spleen index and histological analysis were used to evaluate the splenic structural da
Animal StudyHighlighted
MHID-61354972014Scientific Reports
Chi Liu, Ryosuke Kurokawa, Masayuki Fujino, Shinichi Hirano, Bunpei Sato, Xiao-Kang Li
Hydrogen exerts beneficial effects in disease animal models of ischemia-reperfusion injury as well as inflammatory and neurological disease. Additionally, molecular hydrogen is useful for various novel medical and therapeutic applications in the clinical setting. In the present study, the hydrogen concentration in rat blood and tissue was estimated. Wistar rats were orally administered hydrogen su
Animal Study
MHID-1154767PMID: 249410012014PLoS ONE
Masanori Kawaguchi, Yasushi Satoh, Yukiko Otsubo, Tomiei Kazama
Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain. However, repeated intra-peritoneal or intrathecal injections of antioxidants are unsuitable for continuous use in therapy. Here we show a novel therapeutic method
MHID-9733043PMID: 243927712014Research in sports medicine (Print)
Ostojic SM., Stojanovic MD.
Possible appliance of effective and safe alkalizing agent in the treatment of metabolic acidosis could be of particular interest to humans experiencing an increase in plasma acidity, such as exercise-induced acidosis. In the present study we tested the hypothesis that the daily oral intake of 2L of hydrogen-rich water (HRW) for 14 days would increase arterial blood alkalinity at baseline and post-
Clinical TrialHighlighted
MHID-29235562014Sports medicine / News in Molecular Hydrogen Biomedicine
Sergej M Ostojic, Boris Vukomanovic, Julio Calleja-Gonzalez, Jay R Hoffman
Background: Because hydrogen therapy has been found beneficial for the treatment of inflammation, ischemia-reperfusion injury, and oxidative stress in humans, it seems useful to evaluate the effects of exogenously administered hydrogen as an element in the immediate management of sports-related soft tissue injuries. The main aim of this pilot study was to examine the effects of 2-week administrati
Animal Study
MHID-0185761PMID: 252512202014PLoS ONE
Kenji Dohi, Brian C. Kraemer, Michelle A. Erickson, Pamela J. McMillan, Andrej Kovac, Zuzana Flachbartova, et al.
Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drink
