Convenient methods for ingestion of molecular hydrogen: drinking, injection, and inhalation

Abstract

Molecular hydrogen (H2) is clinically administered; however, in some hospitals, H2 is given to patients without consideration of its safe use. In the present study, we prepared convenient and safe devices for the drinking of super-saturated H2 water, for intravenous drip infusion of H2-rich saline, and for the inhalation of H2 gas. In order to provide useful information for researchers using these devices, the changes in H2 concentration were studied. Our experimental results should contribute to the advance of non-clinical and clinical research in H2 medicine.

Study details

Dose comparison

The study compares H2 concentrations achieved by different preparation methods, temperature effects, and storage times, showing differences in stability and optimal use times.

Dose-dependent effect

Yes

Outcome

Positive

Findings

The study developed and validated convenient and safe devices for the ingestion of molecular hydrogen via drinking super-saturated H2 water, intravenous drip infusion of H2-rich saline, and inhalation of H2 gas. The devices maintained high H2 concentrations for practical durations, and the findings provide useful information for researchers and clinicians regarding the stability and administration of H2.