MHID-3436072PMID: 257209512015Pharmacological research
Ostojic SM.
Although the administration of molecular hydrogen (H2, dihydrogen) has been recognized as an effective innovative therapeutic procedure in biomedicine, H2 cellular kinetics and utilization seems to be less understood. In particular, mitochondrial barriers might impact on H2 use in mitochondria-related diseases and conditions. Double-membrane organization of mitochondria and large membrane potentia
Literature Review
MHID-0477754PMID: 247690812014Pharmacology & Therapeutics
Shigeo Ohta
Molecular hydrogen (H2) has been accepted to be an inert and nonfunctional molecule in our body. We have turned this concept by demonstrating that H2 reacts with strong oxidants such as hydroxyl radical in cells, and proposed its potential for preventive and therapeutic applications. H2 has a number of advantages exhibiting extensive effects: H2 rapidly diffuses into tissues and cells, and it is m
Literature ReviewHighlighted
MHID-8734083PMID: 342834352014Journal of Neurological Disorders
Mami Noda, Kyota Fujita, Ikuroh Ohsawa, Masafumi Ito, Kinji Ohno
Molecular hydrogen (H2) has been reported to be effective for a variety of disorders and its effect has been
ascribed to a selective scavenge of hydroxyl radicals (•OH) at the beginning. Consumption of H2 was either by
inhalation, drinking H2-containing water (H2 water), or infusion of H2-containing saline. Among various disorders,
animal model of ischemic injury and Parkinson’s disease showed sig
Literature ReviewAnimal StudyIn VitroHighlighted
MHID-45285932014European Journal of Neurodegenerative Diseases
Mami Noda, M. Ito, I. Ohsawa, K. Ohno
A new medical gas, molecular hydrogen (H2), has been reported to be effective for a variety of disorders and clinical trials have shown promising results. Though the precise mechanism is still unknown, it is obvious that H2 has multiple effects. The first prominent effect of H2 was as antioxidant or reactive oxygen species (ROS)-scavenger, though it blocks only hydroxyl radicals (•OH), which are t
Literature ReviewHighlighted
MHID-2487803PMID: 306788962013International Journal of Biological Sciences
Liren Qian, Jianliang Shen, Yunhai Chuai, Jianming Cai
It is well known that most of the ionizing radiation-induced damage is caused by hydroxyl radicals (·OH) follows radiolysis of H2O. Molecular hydrogen (H2) has antioxidant activities by selectively reducing ·OH and peroxynitrite(ONOO-). We firstly hypothesized and demonstrated the ra-dioprotective effect of H2 in vitro and in vivo, which was also repeated on different experimental animal models by
Literature Review
MHID-0878205PMID: 236800322013Medical Gas Research
Brandon J Dixon, Jiping Tang, John H Zhang
Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these i
Literature Review
MHID-2828070PMID: 238595552013Current Pharmaceutical Design
Toru Ishibashi
Rheumatoid arthritis (RA) is a chronic inflammatory disease in which the progressive destruction of joint causes morbidity. It is also associated with an increased risk of atherosclerosis, which can result in cardiovascular disease and mortality. The therapeutic goal is to control the systemic inflammation to obtain not only the remission of symptoms, but also improve general state of health. Alth
Literature Review
MHID-8352354PMID: 216215882012Biochimica et Biophysica Acta
Shigeo Ohta
Background: Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effectiv
MHID-7718760PMID: 225374652012Free radical research
Chuai Y, Qian L, Sun X, Cai J.
Molecular hydrogen (dihydrogen, H(2)) acts as a therapeutic antioxidant by selectively reducing hydroxyl radicals (•OH) and peroxynitrite (ONOO-). It has been well-known that ionising radiation (IR) causes oxidative damage and consequent apoptosis mainly due to the production of •OH that follows radiolysis of H(2)O. Our department reported the protective effect of H(2) in irradiated cells and mice
Literature Review
MHID-5039793PMID: 227201172012Oxidative Medicine and Cellular Longevity
Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito
Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson’s disease and three models of Alzheimer’s disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson
Literature ReviewAnimal StudyHighlighted
MHID-2487138PMID: 257255222011Parkinson’s Disease
Kyota Fujita, Yusaku Nakabeppu, Mami Noda
Since the first description of Parkinson’s disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symp- toms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using
Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted
MHID-1756030PMID: 221460822011Medical Gas Research
Shigeo Ohta, Atsunori Nakao, Kinji Ohno
This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.
Literature Review
MHID-2963789PMID: 212269922010The Journal of International Medical Research
Y Hong, S Chen, J-M Zhang
Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H2) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently,
