Systematic ReviewHighlighted
MHID-43477742026World Journal of Orthopedics
Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Shrideavi Murugan, Arulkumar Nallakumarasamy, Sathish Muthu
Molecular hydrogen (H2) demonstrates selective antioxidant and anti-inflam-
matory properties with therapeutic potential across musculoskeletal conditions
including osteoarthritis, rheumatoid arthritis, exercise-induced muscle damage,
chronic pain syndromes, tendinopathies, and muscle atrophy. This review
critically evaluates preclinical and clinical evidence for H2 therapy and identifies
research
Systematic Review
MHID-7472923PMID: 382560452024International Journal of Molecular Sciences
Gagandeep Dhillon, Venkata Buddhavarapu, Harpreet Grewal, Pranjal Sharma, Ram Kishun Verma, Ripudaman Munjal, et al.
Hydrogen-rich water (HRW) has emerged as a novel approach in the field of health and wellness. It is believed to have therapeutic antioxidant properties that can neutralize harmful free radicals in the human body. It has also been shown to be beneficial in mitigating oxidative stress-induced damage through its anti-inflammatory and anti-apoptotic pathways. We aim to conduct a systematic review to
Systematic ReviewMeta-Analysis
MHID-0733746PMID: 385908282024Frontiers in Nutrition
Yiting Li, Renjie Bing, Meng Liu, Zhangyuting Shang, Yan Huang, Kaixiang Zhou, et al.
Objective: Exercise-induced oxidative stress affects multiple neurophysiological processes, diminishing the exercise performance. Hydrogen (H2) can selectively reduce excessive free radicals, but studies observed its “dual effects” on exercise-induced oxidative stress, that is, increasing or decreasing the oxidative stress. Therefore, we here conducted a systematic review and meta-analysis to quan
Meta-AnalysisHighlighted
MHID-22939332024International Journal of Endocrinology and Metabolism
Hamid Jamialahmadi, Ghazaleh Khalili-Tanha, Mostafa Rezaei-Tavirani, Elham Nazari
Context: Metabolic disorders are a growing global concern, especially in developed countries, due to their increasing prevalence. Serum lipid profiles, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), are commonly used clinical biomarkers for monitoring the progression of these metabolic abnormalities. In recent decades, hydro
Meta-AnalysisHypothesisHighlighted
MHID-1049920PMID: 404064272024Gastroenterology and Hepatology From Bed to Bench
Ghazaleh Khalili-Tanha, Hamid Jamialahmadi, Mostafa Rezaei-Tavirani, Elham Nazari
Aim: This systematic review and meta-analysis aimed to assess the effect of hydrogen-rich water (HRW) on liver enzyme levels.
Background: Liver disease is a significant global health concern, greatly affecting mortality rates. Elevated levels of liver enzymes, such as ALT, AST, ALP, and GGT are early symptoms of liver disorders, and various approaches can help reduce them. Recent studies have sho
Systematic ReviewMeta-AnalysisHighlighted
MHID-4133017PMID: 392110452024Frontiers in Immunology
Kang Xiao, Jianwei Liu, Yuxin Sun, Shangya Chen, Jiazi Ma, Mao Cao, et al.
As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta- analysis. We investigated
Systematic ReviewHighlighted
MHID-4621543PMID: 380675152023Molecules
Hennie Marie Johnsen, Marianne Hiorth, Jo Klaveness
With its antioxidant properties, hydrogen gas (H2) has been evaluated in vitro, in animal studies and in human studies for a broad range of therapeutic indications. A simple search of “hydrogen gas” in various medical databases resulted in more than 2000 publications related to hydrogen gas as a potential new drug substance. A parallel search in clinical trial registers also generated many hits, r
Systematic ReviewHighlighted
MHID-32722772023Pharmaceuticals
Nikola Todorovic, Julen Fernández-Landa, Asier Santibañez, Branislav Kura, Valdemar Stajer, Darinka Korovljev, et al.
Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge,
Systematic ReviewHighlighted
MHID-3427886PMID: 373542432023Asian Pacific Journal of Cancer Prevention
Muhammad Nooraiman Zufayri Mohd Noor, Adlin Sofea Alauddin, Yin How Wong, Chung Yeng Looi, Eng Hwa Wong, Priya Madhavan, et al.
Background: Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summaris
Meta-AnalysisHighlighted
MHID-3941772PMID: 368196972023Frontiers in nutrition
Kaixiang Zhou, Liu M, Wang Y, Liu H, Manor B, Bao D, et al.
Background: Fatigue is oftentimes induced by high-intensity exercise potentially via the exceeded amount of reactive oxygen species, leading to diminished functions (e.g., aerobic capacity) and increased risk of injuries. Studies indicate that molecular hydrogen (H2), with antioxidant and anti-inflammatory properties, may be a promising strategy to alleviate fatigue and improve aerobic capacity. H
Literature ReviewSystematic Review
MHID-8761287PMID: 357430352022International Journal of Molecular Sciences
Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar
Currently, there is a lot of public interest in naturally occurring substances with medicinal properties that are minimally toxic, readily available and have an impact on health. Over the past decade, molecular hydrogen has gained the attention of both preclinical and clinical researchers. The death of pyramidal neurons in especially the CA1 area of the hippocampus, increased permeability of the b
Systematic ReviewMeta-AnalysisHighlighted
MHID-6169739PMID: 363888302022Annals of Translational Medicine
Yang Bai, Chenglong Wang, Hua Jiang, Lin Wang, Nan Li, Wei Zhang, et al.
Background: Hydrogen rich water (HRW) was used as an auxiliary treatment for periodontitis and peri-implantitis due to its good antioxidant properties. However, the stability of artificially added active hydrogen was far less than that of pure natural active hydrogen, which greatly reduced active hydrogen molecules number in HRW. Meanwhile, the effect of HRW was relatively slow. Finally, long-term
Systematic ReviewHighlighted
MHID-30922442021Journal of Syiah Kuala Dentistry Society
Albert Manggading Hutapea, Lina Hadi
Diabetes Mellitus (DM) is a metabolic disorder characterized by high blood glucose levels associated with periodontal disease and increased levels of inflammatory biomarkers such as interleukin. Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated. This review aims to systematically analyze and review animal and human studies invest
Literature ReviewMeta-Analysis
MHID-7985788PMID: 328266282020Current Opinion in Anesthesiology
Zhen Wang, Guolin Wang, Keliang Xie
Purpose of review: The current systematic review summarizes recent, basic clinical achievements regarding the neuroprotective effects of molecular hydrogen in distinct central nervous system conditions.
Recent findings: Perioperative neuroprotection remains a major topic of clinical anesthesia. Various gaseous molecules have previously been explored as a feasible therapeutic option in neurologica
