Animal StudyHighlighted
MHID-6252416PMID: 280987682017Nutrients
Toshiki Yoneda, Takaaki Tomofuji, Muneyoshi Kunitomo, Daisuke Ekuni, Koichiro Irie, Tetsuji Azuma, et al.
Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect of hydrogen-rich water may attenuate gingival oxidative stress and prevent alveolar bone resorption in cases of obesity. We examined whether hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption in obese rats fed a high-fat diet. Ma
In VitroHighlighted
MHID-1084413PMID: 264880872016Biochimica et Biophysica Acta - Molecular Cell Research
Jian-Dong Ren, Xiao-Bo Wu, Rui Jiang, Da-Peng Hao, Yi Liu
The NLRP3 inflammasome, an intracellular multi-protein complex controlling the maturation of cytokine interleukin-1β, plays an important role in lipopolysaccharide (LPS)-induced inflammatory cascades. Recently, the production of mitochondrial reactive oxygen species (mtROS) in macrophages stimulated with LPS has been suggested to act as a trigger during the process of NLRP3 inflammasome activation
Animal StudyIn VitroHighlighted
MHID-8667127PMID: 277892932016Free Radical Biology and Medicine
Takafumi Ushida, Tomomi Kotani, Hiroyuki Tsuda, Kenji Imai, Tomoko Nakano, Shima Hirako, et al.
Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of preeclamps
Animal StudyIn VitroHighlighted
MHID-7372149PMID: 268455012016
Yukako Muramatsu, MD, Mikako Ito, PhD, Takahiro Oshima, Seiji Kojima, MD, PhD, Kinji Ohno, MD, PhD
Bronchopulmonary dysplasia (BPD) is characterized by developmental arrest of the alveolar tissue. Oxidative stress is causally associated with development of BPD. The effects of hydrogen have been reported in a wide range of disease models and human diseases especially caused by oxidative stress. We made a rat model of BPD by injecting lipopolysaccharide (LPS) into the amniotic fluid at E16.5. The
Animal StudyHighlighted
MHID-6432478PMID: 259258892015BMC Neuroscience
Satoru Takeuchi, Kimihiro Nagatani, Naoki Otani, Hiroshi Nawashiro, Takashi Sugawara, Kojiro Wada, et al.
Background: Enhanced oxidative stress occurs in spontaneously hypertensive stroke-prone rats (SHRSP), and is important in blood–brain barrier (BBB) disruption. Hydrogen can exert potent protective cellular effects via reduction in oxidative stress in various diseases. The present study investigated whether long-term hydrogen treatment can improve neurological function outcome in the SHRSP model, a
Animal StudyHighlighted
MHID-0865356PMID: 213757532015The Journal of Thoracic and Cardiovascular Surgery
Yasuaki Kishimoto, MD, Taichi Kato, MD, PhD, Mikako Ito, PhD, Yoshiteru Azuma, MD, Yoshie Fukasawa, MD, Kinji Ohno, MD, PhD, et al.
Objective: The pathogenesis of pulmonary arterial hypertension (PAH) involves reactive oxygen species and inflammation. Beneficial effects of molecular hydrogen, which exerts both anti-inflammatory and antioxidative effects, have been reported for various pathologic conditions. We therefore hypothesized that molecular hydrogen would improve monocrotaline (MCT)-induced PAH in rats.
Methods: Nineteen
Animal StudyHighlighted
MHID-8429491PMID: 259549912015Molecular Medicine Reports
HONGWEI LIU, NING HUA, Keliang Xie, TINGTING ZHAO, Yonghao Yu
Overactivation of poly (ADP-ribose) polymerase 1 (PARP-1), as a result of sustained DNA oxidation in ischemia‑reperfusion injury, triggers programmed cell necrosis and apoptosis. The present study was conducted to demonstrate whether hydrogen‑rich saline (HRS) has a neuroprotective effect on retinal ischemia reperfusion (RIR) injury through inhibition of PARP‑1 activation. RIR was induced by trans
Animal Study
MHID-1154767PMID: 249410012014PLoS ONE
Masanori Kawaguchi, Yasushi Satoh, Yukiko Otsubo, Tomiei Kazama
Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain. However, repeated intra-peritoneal or intrathecal injections of antioxidants are unsuitable for continuous use in therapy. Here we show a novel therapeutic method
Animal StudyHighlighted
MHID-1417416PMID: 234757672013American Journal of Physiology - Lung Cellular and Molecular Physiology
Tomohiro Kawamura, Nobunao Wakabayashi, Norihisa Shigemura, Chien-Sheng Huang, Kosuke Masutani, Yugo Tanaka, et al.
Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Hydrogen can be administered as a therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and in
Clinical TrialObservational Study
MHID-7186474PMID: 230310792012Medical Gas Research
Toru Ishibashi, Bunpei Sato, Mariko Rikitake, Tomoki Seo, Ryosuke Kurokawa, Yuichi Hara, et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in the pathogenesis of RA. Recently, molecular hydrogen (H2) was demonstrated to be a selective scavenger for the hydroxyl radical. Also, the method to prepare water containing extrem
Animal StudyHighlighted
MHID-2760312PMID: 221460832011Medical Gas Research
Michio Hashimoto, Masanori Katakura, Toru Nabika, Yoko Tanabe, Shahdat Hossain, Satoru Tsuchikura, et al.
Background: Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in th
In VitroHighlighted
MHID-98352102010Nuclear Technology & Radiation Protection
Liren Qian, Bailong Li, Fei CAO, Yuecheng Huang, Shulin Liu, Jianming Cai, et al.
Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro. Com pared to cells pretreated with out hydrogen, we demonstrated that treating cells with hydrogen-rich PBS be fore irradiat
Animal StudyIn VitroHighlighted
MHID-1312487PMID: 332312662010Free Radical Research
Liren Qian, Fei CAO, Jianguo Cui, Yuecheng Huang, Xiaojian Zhou, Shulin Liu, et al.
It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypoth- esis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could signifi cantly inhib
Animal StudyHighlighted
MHID-2859819PMID: 211161022010Journal of Radiation Research
Liren Qian, Fei CAO, Jianguo Cui, Yicun Wang, Yuecheng Huang, Yunhai Chuai, et al.
Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction
of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause
chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure
water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against
Clinical TrialObservational StudyHighlighted
MHID-8766045PMID: 202169472010Journal of Clinical Biochemistry and Nutrition
Atsunori Nakao, Yoshiya Toyoda, Prachi Sharma, Malkanthi Evans, Najla Guthrie
Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5–2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic
Animal StudyHighlighted
MHID-7978470PMID: 198340322010Investigative Ophthalmology & Visual Science
Hideaki Oharazawa, Tsutomu Igarashi, Takashi Yokota, Hiroaki Fujii, Hisaharu Suzuki, Mitsuru Machide, et al.
PURPOSE. Retinal ischemia-reperfusion (I/R) injury by transient
elevation of intraocular pressure (IOP) is known to induce
neuronal damage through the generation of reactive oxygen
species. Study results have indicated that molecular hydrogen
(H2) is an efficient antioxidant gas that selectively reduces the
hydroxyl radical (OH) and suppresses oxidative stress-induced
injury in several organs. This
Animal StudyHighlighted
MHID-7407969PMID: 195968252009Experimental Biology and Medicine
QIANG SUN, ZHIMIN KANG, JIANMEI CAI, WENWU LIU, YUN LIU, John H Zhang, et al.
Protective effect of hydrogen (H2) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min occlu
Animal StudyHighlighted
MHID-3088793PMID: 193565982009Neuroscience Letters
Yuan Fu, Mikako Ito, Yasunori Fujita, Masafumi Ito, Masatoshi Ichihara, Akio Masuda, et al.
Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but
not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen
has been reported to prevent or ameliorate eight diseases in rodents and one in human
associated with oxidative stress. In Parkinson’s disease, mitochondrial dysfunction and
the associated oxidative stress are major causes of dopam
