Animal StudyHighlighted
MHID-5014710PMID: 407174652025British Journal of Pharmacology
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, et al.
Background and Purpose: Sepsis-induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular pathways underlying this protective effect.
Experime
Literature ReviewHighlighted
MHID-45792272025International Journal of Molecular Sciences
Dominika Zajac, Monika Jampolska, Piotr Wojciechowski
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-
inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current
therapeutic potential among others in inflammatory diseases, cancer, and sports medicine,
among others. The present review aims to provide a consistent summary of the findings
of the last twenty years on the use of molecular hydrogen in
Animal StudyHighlighted
MHID-15287492025Bratislava Medical Journal
Miktat Kaya, Mustafa Makav, Ebru Karadağ Sarı, Şükran Yediel Aras, Mushap Kuru, Abdussamed Vural, et al.
The aim of the study was to investigate the therapeutic efficacy of hydrogen-rich water in pentylenetetrazol-induced epilepsy. A total of 30 female rats, 6 animals in each group, were used in the study. All groups except the control group were ovariec- tomized. Hydrogen-rich water Group (HRW) and Epilepsy + HRW Group (E + HRW) were administered intraperitoneally for 14 days. On the 14th day of the
Animal Study
MHID-7787642PMID: 361994282022Oxidative Medicine and Cellular Longevity
Long Ma, Wei Hao, Wen-Bo Feng, Lu-Cheng Cao, Li-Na Qin, Yao Wang, et al.
Infertility has got to be a broadly concerned social issue these days, in which the male factor cannot be overlooked. Numerous studies have shown that electromagnetic pulse (EMP) radiation may have seriously damaging effects on reproductive health, through nonthermal effects and oxidative stress. Molecular hydrogen, a selective hydroxyl radical scavenger, explains the protective effects against many
Animal Study
MHID-1210077PMID: 333568672021Canadian Journal of Physiology and Pharmacology
Jonatas E. Nogueira, Mateus R. Amorim, Ana P. Pinto, Alisson L. da Rocha, Adelino S. R. da Silva, Luiz G. S. Branco
Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H2) has emerged as a potent antioxidant, anti-inflammatory, and anti-apoptotic agent, but its act
Observational StudyHighlighted
MHID-6285582PMID: 346451002021Journal of Integrative Neuroscience
Tyler W. LeBaron, Jason Kharman, Michael L. McCullough
Traumatic brain injuries (TBIs) are a leading cause of death and dis- ability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeosta- sis, mitochondrial dysfunction, and apoptosis. There is also a reduc- tion in cerebral blood flow, leading to hypoxia and reduced
Animal Study
MHID-1878579PMID: 322460952020Scientific Reports
Yuki Kobayashi, Ryoichi Imamura, Yoshihisa Koyama, Makoto Kondo, Hikaru Kobayashi, Norio Nonomura, et al.
We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant kidney
Animal StudyHighlighted
MHID-0582328PMID: 301085862018Frontiers in Physiology
Jing Chi, Zizhuo Li, Xiaojian Hong
Background: Continuous damage from oxidative stress and apoptosis are the important mechanisms that facilitate chronic heart failure (CHF). Molecular hydrogen (H2) has potentiality in the aspects of anti-oxidation. The objectives of this study were to investigate the possible mechanism of H2 inhalation in delaying the progress of CHF. Methods and Results: A total of 60 Sprague-Dawley (SD) rats wer
Animal StudyIn VitroHighlighted
MHID-9607497PMID: 290409782017Cellular Physiology and Biochemistry
Keyan Chen, Nan Wang, Yugang Diao, Wanwei Dong, YingJie Sun, Lidan Liu, et al.
Background/Aims: Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, and inhibit inflammation. This study investigated effects of HRS on brain injury induced by CPB and regulatory mechanisms of the PI3K/Akt/GSK3β signaling pathway.
Methods: A rat CPB model and an in vitro cell hypoxia model w
Animal StudyHighlighted
MHID-8429491PMID: 259549912015Molecular Medicine Reports
HONGWEI LIU, NING HUA, Keliang Xie, TINGTING ZHAO, Yonghao Yu
Overactivation of poly (ADP-ribose) polymerase 1 (PARP-1), as a result of sustained DNA oxidation in ischemia‑reperfusion injury, triggers programmed cell necrosis and apoptosis. The present study was conducted to demonstrate whether hydrogen‑rich saline (HRS) has a neuroprotective effect on retinal ischemia reperfusion (RIR) injury through inhibition of PARP‑1 activation. RIR was induced by trans
Animal StudyHighlighted
MHID-5761446PMID: 246182602014Journal of Cellular and Molecular Medicine
Sanhu Zhao, Yanyong Yang, Wen Liu, Zhiqiang Xuan, Shouming Wu, Shunfei Yu, et al.
Recent studies showed that hydrogen can be used as an effective radioprotective agent through scavenging free radicals. This study was under-
taken to evaluate the radioprotective effects of hydrogen on immune system in mice. H2 was dissolved in physiological saline using an apparatus
produced by our department. Spleen index and histological analysis were used to evaluate the splenic structural da
Animal Study
MHID-20640112012Shock
Keliang Xie, Yonghao Yu, Yi Huang, Lina Zheng, Jipeng Li, Hongguang Chen, et al.
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our and other studies have found that hydrogen gas (H2) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecular mechanisms by which H2 ameliorates lung injury remain unclear. In the current study, we investigat
Animal StudyHighlighted
MHID-2777514PMID: 225876642012BMC Neuroscience
Zong Zhuang, Meng-liang Zhou, Wan-chun You, Lin Zhu, Chi-yuan Ma, Xue-Jun Sun, et al.
Background: Increasing experimental and clinical data indicate that early brain injury (EBI) after subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes, and it has been proved that EBI following SAH is closely associated with oxidative stress and brain edema. The present study aimed to examine the effect of hydrogen, a mild and selective cytotoxic oxygen radical scavenger, on
