Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent

Abstract

We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant kidney rats and Parkinson’s disease mice. Rats are fed with control or Si-based agent-containing diet for 8 weeks. Si-based agent is found to greatly suppress the development of renal failure and the parameters of oxidative stress. Treatment with Si-based agent in a mouse model of hemi-Parkinson’s disease induced by 6-hydroxydopamine attenuated degeneration of dopaminergic neurons and prevented impairment of motor balance and coordination. These findings indicate that the Si-based agent shows renoprotective and neuroprotective effects presumably via suppression of oxidative stress by generation of hydrogen.

Study details

Article type

Original Research

Disease / injury model

Renal: (5/6) nephrectomy. Neurological: 6-OHDA-induced Parkinson’s disease

Duration

8 weeks

Dose comparison

0.1wt.%, 0.5wt.% &1.0wt.% for Rats; 2.5%wt. for mice

Dose-dependent effect

Yes

Outcome

Neutral

Findings

In the present study, the authors developed a Si-based agent that generates a large amount of hydrogen continuously. The Si-based agent showed reno-protective and neuroprotective effects in animal models.