Systematic ReviewHighlighted
MHID-43477742026World Journal of Orthopedics
Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Shrideavi Murugan, Arulkumar Nallakumarasamy, Sathish Muthu
Molecular hydrogen (H2) demonstrates selective antioxidant and anti-inflam-
matory properties with therapeutic potential across musculoskeletal conditions
including osteoarthritis, rheumatoid arthritis, exercise-induced muscle damage,
chronic pain syndromes, tendinopathies, and muscle atrophy. This review
critically evaluates preclinical and clinical evidence for H2 therapy and identifies
research
Animal StudyHighlighted
MHID-8967574PMID: 416411602026Frontiers in Nutrition
Eika Mizuno, Tatsuhiro Sato, Kosuke Okada, Ikuru Miura, Junichi Shoda, Makoto Saito, et al.
Introduction: Hydrogen-rich water (HRW) has been reported to reduce oxidative stress, suppress exercise fatigue, and enhance recovery. However, the molecular mechanisms of its effects on exercise capacity, especially during the early stages of adaptation in physically inactive individuals, remain unclear.
Methods: Male 8-week-old C57BL/6 J mice were provided with purified water or HRW for 1, 2, 4,
Animal StudyHighlighted
MHID-6449583PMID: 412075402026Journal of Nutritional Biochemistry
Naomi Kamimura, Katsuya Iuchi, Tsutomu Igarashi, Ikuroh Ohsawa, Chikako Nito, Jitsuo Usuda, et al.
Acetaminophen (APAP) overdose induces severe liver injury, especially in diabetic patients. N -acetylcysteine (NAC) is commonly used as an approved an- tidote for APAP toxicity; however, its narrow therapeutic window limits its clinical utility. This study investigated the protective effects of molecular hydro- gen (H2 ) against APAP-induced hepatotoxicity in diabetic mice. Diabetic db/db mice wer
Animal StudyIn VitroHighlighted
MHID-1663779PMID: 405801852026Medical Gas Research
Yinyin Zhang, Yajing Ying, Xianpeng Zu, Lingling Ding, Xuan Shi, Jing Wang, et al.
Exercise-induced fatigue limits athletic performance. Molecular hydrogen is an effective treatment for relieving fatigue, but the exact mechanism is not clear. In our study, a mouse model of fatigue was established to explore the molecular mechanism by which hydrogen-rich water reduces exercise-induced fatigue. The results showed that hydrogen-rich water improved the motor function of fatigue mice
Animal StudyIn VitroHighlighted
MHID-9975059PMID: 394361892025Medical Gas Research
Wanqiu Chen, Yinyin Zhang, Gen Miao, Yajing Ying, Zifu Ren, Xuejun Sun, et al.
There is strong evidence connecting increased serum lipid levels to cardiovascular disorders, including atherosclerosis. Statins is prescribed as the primary medication to decrease lipid levels. Recent research has demonstrated that hydrogen possesses anti-inflammatory and antioxidant properties by modulating the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, ultima
HypothesisOpinion PieceHighlighted
MHID-6155704PMID: 402510252025Medical Gas Research
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
The increasing prevalence of obesity and non-communicable diseases has become a major global health concern, contributing to significant morbidity and mortality rates. These conditions not only burden healthcare systems but also affect the individual’s quality of life worldwide. As these challenges continue to grow, there is a pressing need to explore treatment options that are effective, affordab
Animal StudyHighlighted
MHID-4439338PMID: 401810802025Scientific Reports
Victor Pascal-Moussellard, Jean-Pierre Alcaraz, Stéphane Tanguy, Cordélia Salomez-Ihl, Philippe Cinquin, François Boucher, et al.
Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well as in clinical trials. As H2 is one of the major byproducts of inulin fermentation by bacterial species of the gut microbiota (GM), we hypothesized that H2 could mediate the antitumor effects of inulin. To provide evidence in favor of this hypothesis, we first determined the pattern of
Animal StudyHighlighted
MHID-5014710PMID: 407174652025British Journal of Pharmacology
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, et al.
Background and Purpose: Sepsis-induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular pathways underlying this protective effect.
Experime
Literature ReviewHighlighted
MHID-2922681PMID: 413737252025International Journal of Molecular Sciences
Daria Kornieieva, Barbora Kalocayova, Jan Slezak, Branislav Kura
Heart failure (HF) is increasing in prevalence in many countries around the world. HF is a complex clinical syndrome characterized by the heart’s inability to pump blood effectively, resulting in significant morbidity and mortality. After an initial cardiac event (e.g., myocardial infarction, valve dysfunction, hypertension, etc.), adaptive mechanisms are activated to preserve cardiac function. Su
Animal StudyHighlighted
MHID-2282117PMID: 408679002025Antioxidants
Ignacio Martínez-Martel, Sylmara Esther Negrini-Ferrari, Olga Pol
Cisplatin (CIS)-induced peripheral neuropathy and associated comorbidities have a detrimental effect on the lives of cancer patients. Currently, there are no effective therapies to alleviate these symptoms. Duloxetine (DULO) is a recommended treatment, but it is linked with important side effects, thus making it essential to explore novel approaches. We examined the impact of a prophylactic treatm
Animal StudyIn VitroHighlighted
MHID-7622818PMID: 407051912025Molecular Biology Reports
Yan Tian, Huilan Su, Yunxi Chen, Xiaomeng Geng, Yafang Zhang, Yu Wang, et al.
Background Nephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose- limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H2) has emerged as a therapeutic agent with potent antioxidant and anti-inflammatory properties, selectively scavenging hydroxyl radicals and alleviati
Literature ReviewHighlighted
MHID-45792272025International Journal of Molecular Sciences
Dominika Zajac, Monika Jampolska, Piotr Wojciechowski
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-
inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current
therapeutic potential among others in inflammatory diseases, cancer, and sports medicine,
among others. The present review aims to provide a consistent summary of the findings
of the last twenty years on the use of molecular hydrogen in
Animal StudyIn VitroHighlighted
MHID-1674678PMID: 407251672025International Journal of Molecular Sciences
Sofian Abdul-Nasir, Cat Tuong Chau, Tien Thuy Nguyen, Johny Bajgai, Md. Habibur Rahman, Kwon Hwang-Un, et al.
Alzheimer’s disease (AD) is a neurodegenerative condition in which amyloid-beta (Aβ) plaques trigger oxidative stress (OS) and neuroinflammation, causing memory loss. OS and neurodegeneration can also be caused by reactive astrocytes, thereby promoting AD via toxic metabolite accumulation in the astrocytic urea cycle. However, the effect of molecular hydrogen (H2) on this cycle remains unknown. Th
Animal StudyEx VivoHighlighted
MHID-4421003PMID: 398164752025Bioactive Materials
Yuanming An, Haozhi Zhang, Shi’an Zhang, Yuantao Zhang, Lizhen Zheng, Xin Chen, et al.
Biodegradable magnesium (Mg) implant generally provides temporary fracture fixation and facilitates bone regeneration. However, the exact effects of generated Mg ions (Mg2+), hydrogen gas (H2), and hydroxide ions (OH-) by Mg degradation on enhancing fracture healing are not fully understood. Here we investigate the in vivo degradation of Mg intramedullary nail (Mg-IMN), revealing the generation of
Animal StudyIn VitroEx VivoHighlighted
MHID-9370665PMID: 404119852025Biomaterials
Yuanming An, Lizhen Zheng, Shi’an Zhang, Haozhi Zhang, Yuantao Zhang, Hongwei Shao, et al.
Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing SAON model). Here we find that HRW treatment significantly reduces osteocyte apoptosis, improves deterio
Animal StudyIn VitroHighlighted
MHID-8939519PMID: 413302172025Redox Biology
Shuto Negishi, Mikako Ito, Tomoya Hasegawa, Hikaru Otake, Bisei Ohkawara, Akio Masuda, et al.
The mechanisms underlying the biomedical effects of molecular hydrogen (H2) remain poorly understood and
are often attributed to its selective reduction of hydroxyl radicals, based on the long-held notion that H2 is
biologically inert. We demonstrate that H2 is biologically active, specifically targeting the Rieske iron-sulfur
protein (RISP). We first observed that H2 induces the mitochondrial unf
Animal Study
MHID-5436392PMID: 389291852024Antioxidants
Hung-Tsung Wu, Chin-Shiang Tsai, Ting-Hsing Chao, Horng-Yih Ou, Liang-Miin Tsai
The prevalence of non-alcoholic fatty liver disease (NAFLD) has dramatically increased in recent years, and it is highly associated with metabolic diseases, as well as the development of hepatocellular carcinoma. However, effective therapeutic strategies for the treatment of NAFLD are still scarce. Although hydrogen-rich water shows beneficial effects for hepatic steatosis, the inconvenience limit
Animal StudyHighlighted
MHID-8252742PMID: 395944702024Antioxidants
Wenjing He, Md. Habibur Rahman, Johny Bajgai, Sofian Abdul-Nasir, Chaodeng Mo, Hui Ma, et al.
Airway inflammatory diseases, such as asthma, are a global public health concern owing to their chronic inflammatory effects on the respiratory mucosa. Molecular hydrogen (H2) has recently been recognized for its antioxidant and anti-inflammatory properties. In this study, we examined the therapeutic potential of H2 in airway inflammation using an ovalbumin (OVA)-induced BALB/c mouse model of alle
Animal Study
MHID-5679511PMID: 383958002024BMC Anesthesiology
Yan Cui, Yingning Li, Shuqi Meng, Yu Song, Keliang Xie
Background: Approximately 40 to 60% of patients with sepsis develop sepsis-induced cardiomyopathy (SIC), which is associated with a substantial increase in mortality. We have found that molecular hydrogen (H2) inhalation improved the survival rate and cardiac injury in septic mice. However, the mechanism remains unclear. This study aimed to explore the regulatory mechanism by which hydrogen modula
Animal Study
MHID-3239928PMID: 386383342024Frontiers in Pharmacology
Weiming Yan, Qiurui He, Pan Long, Tao Chen, Lei Zhang, Haiyan Wang
Objective Our research was performed in order to explore the effects of molecular hydrogen (H2), a novely-established antioxidant, on the retinal degeneration in rd1 mice, an animal model of inherited retinitis pigmentosa (RP).
Methods The rd1 mice were divided randomly into control and H2 intervention groups. Mice from other groups received H2 intervention in three modes, two modes of the hydrog
