Animal StudyIn VitroHighlighted
MHID-5401653PMID: 413343742026Bioactive Materials
Yue Yuan, Zishuo Hou, Miaomiao Chen, Jingwei Yu, Minghao Zhou, Jiaxin Kang, et al.
The weaker soft tissue integration around implants compared to natural teeth poses a substantial challenge to the long-term success of implants. To enhance soft tissue integration, we develop an on-demand and long-lasting H2-releasing implant to achieve precise sequential regulation of the soft tissue integration through immunomodulation and pro-remodeling coupling. In the inflammatory phase, the
Animal StudyHighlighted
MHID-8967574PMID: 416411602026Frontiers in Nutrition
Eika Mizuno, Tatsuhiro Sato, Kosuke Okada, Ikuru Miura, Junichi Shoda, Makoto Saito, et al.
Introduction: Hydrogen-rich water (HRW) has been reported to reduce oxidative stress, suppress exercise fatigue, and enhance recovery. However, the molecular mechanisms of its effects on exercise capacity, especially during the early stages of adaptation in physically inactive individuals, remain unclear.
Methods: Male 8-week-old C57BL/6 J mice were provided with purified water or HRW for 1, 2, 4,
Animal StudyHighlighted
MHID-6449583PMID: 412075402026Journal of Nutritional Biochemistry
Naomi Kamimura, Katsuya Iuchi, Tsutomu Igarashi, Ikuroh Ohsawa, Chikako Nito, Jitsuo Usuda, et al.
Acetaminophen (APAP) overdose induces severe liver injury, especially in diabetic patients. N -acetylcysteine (NAC) is commonly used as an approved an- tidote for APAP toxicity; however, its narrow therapeutic window limits its clinical utility. This study investigated the protective effects of molecular hydro- gen (H2 ) against APAP-induced hepatotoxicity in diabetic mice. Diabetic db/db mice wer
Animal StudyIn VitroHighlighted
MHID-1663779PMID: 405801852026Medical Gas Research
Yinyin Zhang, Yajing Ying, Xianpeng Zu, Lingling Ding, Xuan Shi, Jing Wang, et al.
Exercise-induced fatigue limits athletic performance. Molecular hydrogen is an effective treatment for relieving fatigue, but the exact mechanism is not clear. In our study, a mouse model of fatigue was established to explore the molecular mechanism by which hydrogen-rich water reduces exercise-induced fatigue. The results showed that hydrogen-rich water improved the motor function of fatigue mice
Animal StudyHighlighted
MHID-1198842PMID: 406436492025Naunyn-Schmiedeberg's Archives of Pharmacology
Muhammed Deniz, Yeliz Akkuş, Gülden Yıldız, Hatice Beşeren Havadar, Mustafa Makav
This study was carried out in an experimental study design with experimental and control groups to investigate the effect of hydrogen-enriched water (HRW) on healing in excisional full-layer skin wounds. The rats were divided into diabetic group (n = 20) and non-diabetic group (n = 18) (n = 38). Diabetic group was divided into three groups as diabetic wound (DC), diabetic wound saline (DS), and di
Clinical TrialAnimal StudyHighlighted
MHID-05612832025Sportivnaya meditsina: nauka i praktika (Sports medicine: research and practice)
Oleg S. Medvedev, Aleksey A. Uzhakov, Olga L. Konnova, Oxana V. Povarova
Purpose of the study: to investigate the effect of periodic hydrogen inhalations for one month on the main performance characteristics, lactate levels and other biochemical parameters determined in the blood of young wrestlers after physical activity.
Materials and methods. 10 healthy volunteer athletes took part in a prospective clinical study. The analysis of hydrogen and methane levels in exha
Animal StudyIn VitroHighlighted
MHID-9975059PMID: 394361892025Medical Gas Research
Wanqiu Chen, Yinyin Zhang, Gen Miao, Yajing Ying, Zifu Ren, Xuejun Sun, et al.
There is strong evidence connecting increased serum lipid levels to cardiovascular disorders, including atherosclerosis. Statins is prescribed as the primary medication to decrease lipid levels. Recent research has demonstrated that hydrogen possesses anti-inflammatory and antioxidant properties by modulating the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, ultima
Animal StudyHighlighted
MHID-8093676PMID: 401048812025Veterinary Medicine and Science
Buket Boğa Kuru, Mustafa Makav, Mushap Kuru, Şükran Yediel Aras, Ebru Karadağ Sarı, Menekşe Bulut, et al.
Objectives: This study investigated the impact of drinking hydrogen-rich water (HRW) on growth performance, organ weights, thiol/disulphide homeostasis, oxidative status and some hormonal, histopathological and immunohistochemical changes in rats fed in a restricted housing environment.
Methods: The eight groups (each group [male/female] eight rats) comprised two control, two hydrogen, two stress
Animal StudyHighlighted
MHID-6979663PMID: 401889722025Toxicology and Applied Pharmacology
Mohammad Hossein Rigi, Seyyedeh Zahra Asghari, Elaheh Eshtad, Seyedeh Elnaz Nazari, Akram Aminian, Khatereh Kharazmi, et al.
Obesity can impair spermatogenesis by various mechanisms such as decreased sperm concentration and increased oxidative DNA damage. Hydrogen-rich water (HRW) possesses therapeutic antioxidant properties that may help offer protection to sperm. This study aimed to investigate the therapeutic potential of HRW on spermatogenesis dysfunction in rats with high-fat diet (HFD)-induced obesity. In this exp
Animal StudyHighlighted
MHID-4439338PMID: 401810802025Scientific Reports
Victor Pascal-Moussellard, Jean-Pierre Alcaraz, Stéphane Tanguy, Cordélia Salomez-Ihl, Philippe Cinquin, François Boucher, et al.
Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well as in clinical trials. As H2 is one of the major byproducts of inulin fermentation by bacterial species of the gut microbiota (GM), we hypothesized that H2 could mediate the antitumor effects of inulin. To provide evidence in favor of this hypothesis, we first determined the pattern of
Animal StudyHighlighted
MHID-6800574PMID: 414626182025Antioxidants
Anna Vyacheslavovna Deryugina, Darya Andreevna Danilova, Anastasia Vladimirovna Polozova
Oxidative stress is a key factor in the development of chronic heart failure (CHF). Molecular hydrogen (H2) exhibits antioxidant properties, yet the mechanisms by which it alleviates hemodynamic disturbances and ischemic myocardial injury in CHF are not fully under- stood. This study examined the effects of a single (40-min) and multiple (40-min daily for 5 days) inhalations of H2 in a rat model o
Animal StudyHighlighted
MHID-5014710PMID: 407174652025British Journal of Pharmacology
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, et al.
Background and Purpose: Sepsis-induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular pathways underlying this protective effect.
Experime
Animal StudyHighlighted
MHID-2282117PMID: 408679002025Antioxidants
Ignacio Martínez-Martel, Sylmara Esther Negrini-Ferrari, Olga Pol
Cisplatin (CIS)-induced peripheral neuropathy and associated comorbidities have a detrimental effect on the lives of cancer patients. Currently, there are no effective therapies to alleviate these symptoms. Duloxetine (DULO) is a recommended treatment, but it is linked with important side effects, thus making it essential to explore novel approaches. We examined the impact of a prophylactic treatm
Animal StudyIn VitroHighlighted
MHID-7622818PMID: 407051912025Molecular Biology Reports
Yan Tian, Huilan Su, Yunxi Chen, Xiaomeng Geng, Yafang Zhang, Yu Wang, et al.
Background Nephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose- limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H2) has emerged as a therapeutic agent with potent antioxidant and anti-inflammatory properties, selectively scavenging hydroxyl radicals and alleviati
Animal StudyHighlighted
MHID-5834617PMID: 398578172025Biomedicines
Masaki Shibuya, Masafumi Fujinaka, Mako Yonezawa, Natsumi Nishimura, Hitoshi Uchinoumi, Hiroshi Sunahara, et al.
Background: Hydrogen gas (H2) has been shown to be effective in the treatment of various clinical conditions, from acute illnesses to chronic illnesses. However, its clinical indications and the corresponding appropriate hydrogen delivery methods have yet to be determined. This is due to the fact that the pharmacokinetics and pharmacodynamics of hydrogen in each delivery method have not been exper
Animal StudyIn VitroHighlighted
MHID-7283969PMID: 417999532025Materials Today Bio
Chunru Kong, Chao Si, Haofeng Liu, Yawen Wang, Jiakai Qiao, Xiaoduo Tang, et al.
The repair of infected bone defects (IBDs) presents a significant clinical challenge due to recurrent infections and
inflammation. Characterized by reactive oxygen species (ROS) bursts and mitochondrial dysfunction, IBDs
generates to a vicious oxidation-inflammation cycle that impairs bone remodeling. To address this, we developed
a double-network hydrogel scaffold composed of phenylboronic acid-m
Animal StudyIn VitroHighlighted
MHID-1674678PMID: 407251672025International Journal of Molecular Sciences
Sofian Abdul-Nasir, Cat Tuong Chau, Tien Thuy Nguyen, Johny Bajgai, Md. Habibur Rahman, Kwon Hwang-Un, et al.
Alzheimer’s disease (AD) is a neurodegenerative condition in which amyloid-beta (Aβ) plaques trigger oxidative stress (OS) and neuroinflammation, causing memory loss. OS and neurodegeneration can also be caused by reactive astrocytes, thereby promoting AD via toxic metabolite accumulation in the astrocytic urea cycle. However, the effect of molecular hydrogen (H2) on this cycle remains unknown. Th
Animal StudyIn VitroHighlighted
MHID-4061148PMID: 406876592025Translational Andrology and Urology
Qijie Chen, Shaoqing Yu, Yating Pan, Hong Tang, Yang Wang, Ninghan Feng, et al.
Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, leading to severe systemic complications and reduced quality of life. Current therapies often fail to comprehensively alleviate diabetic complications, highlighting the need for novel approaches. Animal studies and clinical trials have demonstrated the therapeutic potential of molecular hy
Animal StudyHighlighted
MHID-0413972PMID: 401127282025Food Chemistry
Hilal Kanmaz, Didem Şahingil, Duried Alwazeer, Menekşe Bulut, Mushap Kuru, Mustafa Makav, et al.
This study aimed to investigate the effects of hydrogen-rich water (HRW) consumption in goats on the chemical composition, antioxidant activity, total phenolic content, in vitro antidiabetic activity (α-amylase and α-glucosidase inhibitions), free fatty acid profile, and volatile compounds of colostrum and mature milk. Goats were fed ad libitum with either normal water (NW) or HRW for 20–22 days b
Animal StudyEx VivoHighlighted
MHID-4421003PMID: 398164752025Bioactive Materials
Yuanming An, Haozhi Zhang, Shi’an Zhang, Yuantao Zhang, Lizhen Zheng, Xin Chen, et al.
Biodegradable magnesium (Mg) implant generally provides temporary fracture fixation and facilitates bone regeneration. However, the exact effects of generated Mg ions (Mg2+), hydrogen gas (H2), and hydroxide ions (OH-) by Mg degradation on enhancing fracture healing are not fully understood. Here we investigate the in vivo degradation of Mg intramedullary nail (Mg-IMN), revealing the generation of
