Animal StudyIn VitroHighlighted
MHID-9975059PMID: 394361892025Medical Gas Research
Wanqiu Chen, Yinyin Zhang, Gen Miao, Yajing Ying, Zifu Ren, Xuejun Sun, et al.
There is strong evidence connecting increased serum lipid levels to cardiovascular disorders, including atherosclerosis. Statins is prescribed as the primary medication to decrease lipid levels. Recent research has demonstrated that hydrogen possesses anti-inflammatory and antioxidant properties by modulating the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, ultima
HypothesisOpinion PieceHighlighted
MHID-6155704PMID: 402510252025Medical Gas Research
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
The increasing prevalence of obesity and non-communicable diseases has become a major global health concern, contributing to significant morbidity and mortality rates. These conditions not only burden healthcare systems but also affect the individual’s quality of life worldwide. As these challenges continue to grow, there is a pressing need to explore treatment options that are effective, affordab
Animal StudyIn VitroEx VivoHighlighted
MHID-9370665PMID: 404119852025Biomaterials
Yuanming An, Lizhen Zheng, Shi’an Zhang, Haozhi Zhang, Yuantao Zhang, Hongwei Shao, et al.
Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing SAON model). Here we find that HRW treatment significantly reduces osteocyte apoptosis, improves deterio
Clinical TrialHighlighted
MHID-1498378PMID: 392581912024Heliyon
Fenglin Wu, Jun Ma, Junli Xue, Xue Jiang, Jinyu Liu, Jiashuo Zhang, et al.
Background: Consumption of hydrogen-rich water (HRW) has been shown to have anti- inflammatory and metabolic-modulatory benefits.
Objective: A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia.
Methods: The Placebo grou
Clinical TrialObservational StudyHighlighted
MHID-1663378PMID: 383995332024Medicina
Shih-Feng Liu, Chin-Ling Li, Hui-Ching Lee, Hui-Chuan Chang, Jui-Fang Liu, Ho-Chang Kuo
Background and Objectives: Recent studies suggest that hydrogen gas possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. This study aimed to explore the therapeutic potential of hydrogen gas and assess its safety and tolerability in individuals with chronic obstructive pulmonary disease (COPD). Materials and Methods: Enrolled COPD patients received standard treatments along wit
Clinical TrialHighlighted
MHID-7984305PMID: 389082962024The Journal of Nutrition, Health and Aging
Sonja Baltic, David Nedeljkovic, Nikola Todorovic, Marijana Ranisavljev, Darinka Korovljev, Jelena Cvejic, et al.
Objectives: To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment.
Design: A parallel-group, randomized, placebo-controlled, double-blind experimental design, maintaining a 1:1 allocation ratio between the experimental group (
Observational StudyHighlighted
MHID-0293642PMID: 375214102023Frontiers in Nutrition
Szu-Han Chiu, Frank L. Douglas, Jia-Ru Chung, Kuang-Yih Wang, Chao-Fang Chu, Hsia-Yun Chou, et al.
Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high visceral fat. Metabolic syndrome is linked to the build-up of plaque within the artery, which leads to disorders of the circulatory, nervous and immune systems. A variety of treatments targ
Systematic ReviewHighlighted
MHID-32722772023Pharmaceuticals
Nikola Todorovic, Julen Fernández-Landa, Asier Santibañez, Branislav Kura, Valdemar Stajer, Darinka Korovljev, et al.
Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge,
Animal StudyIn VitroHighlighted
MHID-1279019PMID: 372155682023Theranostics
Geru Tao, Feng Liu, Zhaokui Jin, Boyan Liu, Hao Wang, Daosheng Li, et al.
Background: Chronic liver diseases (CLD) frequently derive from hepatic steatosis, inflammation and fibrosis, and become a leading inducement of cirrhosis and hepatocarcinoma. Molecular hydrogen (H2) is an emerging wide-spectrum anti-inflammatory molecule which is able to improve hepatic inflammation and metabolic dysfunction, and holds obvious advantages in biosafety over traditional anti-CLD dru
Clinical TrialHighlighted
MHID-1269854PMID: 362782212022Frontiers in Pharmacology
Boyan Liu, Xue Jiang, Yunbo Xie, Xiubin Jia, Jiashuo Zhang, Yazhuo Xue, et al.
Objective: To explore the effect of a low-dose hydrogen–oxygen (H2-O2) mixture inhalation in midlife/older adults with hypertension.
Methods: This randomized, placebo-controlled trial included 60 participants with hypertension aged 50–70 years who were randomly divided into Air group (inhaled placebo air) or H2-O2 group [inhaled H2-O2 mixture (66% H2/33% O2)]. Participants in both groups were tre
Clinical TrialAnimal StudyIn VitroHighlighted
MHID-2649268PMID: 357349742022Journal of Cellular and Molecular Medicine
Geru Tao, Guangjie Zhang, Wei Chen, Chao Yang, Yazhuo Xue, Guohua Song, et al.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide with increasing incidence consistent with obesity, type 2 diabetes and
cardiovascular diseases. No approved medication was currently available for NAFLD
treatment. Molecular hydrogen (H2), an anti-oxidative, anti-inflammatory biomedical
agent is proved to exhibit therapeutic and preventive effect in variou
Clinical TrialHighlighted
MHID-6639794PMID: 362906572022Antioxidants
Branislav Kura, Mária Szántová, Tyler W. LeBaron, Viliam Mojto, Miroslav Barancik, Barbara Szeiffova Bacova, et al.
Non-alcoholic fatty liver disease (NAFLD) is a liver pathology affecting around 25% of the population worldwide. Excess oxidative stress, inflammation and aberrant cellular signaling can lead to this hepatic dysfunction and eventual carcinoma. Molecular hydrogen has been recognized for its selective antioxidant properties and ability to attenuate inflammation and regulate cellular function. We admin
Clinical TrialHighlighted
MHID-5701846PMID: 322737402020Diabetes, Metabolic Syndrome and Obesity
Tyler W. LeBaron, Ram B. Singh, Ghizal Fatima, Kumar Kartikey, Jagdish P Sharma, Sergej M Ostojic, et al.
Purpose: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition increase the risk of cardiovascular and neurological disease and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular hom
Clinical Trial
MHID-9868845PMID: 285605192018Irish Journal of Medical Science
D. Korovljev, T. Trivic, P. Drid, S. M. Ostojic
Background: Molecular hydrogen (H2) effectively treats obesity-related disorders in animal models, yet no studies have investigated the effectiveness and safety of H2 for improving biomarkers of obesity in humans.
Aim: In this double blind, placebo-controlled, crossover pilot trial, we evaluated the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in ten
Literature ReviewHighlighted
MHID-2847992PMID: 278264242016Medical Gas Research
Ou-yang Chen, Zhou-heng Ye, Chong Li
June 27, 2015, the Second Hydrogen Molecule Biomedical Symposium and the Second meeting of the Professional Committee of Molecular Hydrogen Biology and Medicine of China Association of Promoting International Communication of health care was grand opening in the Capital of China, Beijing, sponsored by China Association of Promoting International Communication of health care, undertaken by Professi
