Animal Study
MHID-5679511PMID: 383958002024BMC Anesthesiology
Yan Cui, Yingning Li, Shuqi Meng, Yu Song, Keliang Xie
Background: Approximately 40 to 60% of patients with sepsis develop sepsis-induced cardiomyopathy (SIC), which is associated with a substantial increase in mortality. We have found that molecular hydrogen (H2) inhalation improved the survival rate and cardiac injury in septic mice. However, the mechanism remains unclear. This study aimed to explore the regulatory mechanism by which hydrogen modula
Animal Study
MHID-6003573PMID: 364684152023CNS Neuroscience & Therapeutics
Qingqing Han, Yuanyuan Bai, Chunjing Zhou, Beibei Dong, Yingning Li, Ning Luo, et al.
Introduction: In our experiments, male wild-type mice were randomly divided into four groups: the sham, SAE, SAE + 2% hydrogen gas inhalation (H2), and SAE + hydrogen-rich water (HW) groups. The feces of the mice were collected for 16 S rDNA analysis 24 h after the models were established, and the serum and brain tissue of the mice were collected for nontargeted metabolomics analysis.
Aim: Destru
Animal Study
MHID-6821344PMID: 281483012017BMC Musculoskeletal Disorders
Jia Li, Zhaogang Ge, Lihong Fan, Kunzheng Wang
Background: The objective of this study was to investigate the protective effects of molecular hydrogen, a novel and selective antioxidant, on steroid-induced osteonecrosis (ON) in a rabbit model.
Methods: Sixty rabbits were randomly divided into two groups (model group and hydrogen group). Osteonecrosis was induced according to an established protocol of steroid-induced ON. Rabbits in the hydrog
In Vitro
MHID-7973359PMID: 284674972017PLOS ONE
Yayoi Murakami, Masafumi Ito, Ikuroh Ohsawa
Inhalation of molecular hydrogen (H2) gas ameliorates oxidative stress-induced acute injuries in the brain. Consumption of water nearly saturated with H2 also prevents chronic neurodegenerative diseases including Parkinson’s disease in animal and clinical studies. However, the molecular mechanisms underlying the remarkable effect of a small amount of H2 remain unclear. Here, we investigated the ef
In Vitro
MHID-3711683PMID: 238265192013International Journal of Ophthalmology
GD Liu, H Zhang, L Wang, Q Han, SF Zhou, P Liu
AIM: To explore the potential mechanism of molecular hydrogen in the regulation of miRNA expression and signal-modulating activities.
METHODS: Retinal microglia cells were activated by Lipopolysaccharides (LPS) and then treated with hydrogen -saturated medium or normal medium without hydrogen. qRT-PCR was used to detect the expression difference in miR-9, miR-21 and miR-199 between these two grou
Animal StudyIn VitroHighlighted
MHID-5929908PMID: 191486452009Cancer Chemotherapy and Pharmacology
Naomi Nakashima-Kamimura, Takashi Mori, Ikuroh Ohsawa, Sadamitsu Asoh, Shigeo Ohta
Purpose: Cisplatin is a widely used anti-cancer drug in the treatment of a wide range of tumors; however, its application is limited by nephrotoxicity, which is affected by oxidative stress. We have reported that molecular hydrogen (H(2)) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688-694, 2007). Here we show that hydrogen efficiently mitigates the side effects of cisplatin by r
