Clinical TrialHighlighted
MHID-6639794PMID: 362906572022Antioxidants
Branislav Kura, Mária Szántová, Tyler W. LeBaron, Viliam Mojto, Miroslav Barancik, Barbara Szeiffova Bacova, et al.
Non-alcoholic fatty liver disease (NAFLD) is a liver pathology affecting around 25% of the population worldwide. Excess oxidative stress, inflammation and aberrant cellular signaling can lead to this hepatic dysfunction and eventual carcinoma. Molecular hydrogen has been recognized for its selective antioxidant properties and ability to attenuate inflammation and regulate cellular function. We admin
Animal StudyHighlighted
MHID-9667503PMID: 349703492022Experimental and Therapeutic Medicine
Yun Hu, Xiaoyan Feng, Junhui Chen, Yan Wu, Liuyan Shen
Traumatic brain injury (TBI) has been recognized as a serious public health issue and a key contributor to disability and death, with a huge economic burden worldwide. Hydrogen, which is a slight and specific cytotoxic oxygen radical scav‑enger, has been demonstrated to ameliorate early brain injury (EBI) through reactive oxygen species (ROS), oxidative stress injury, apoptosis and necroptosis. Ne
Animal StudyIn VitroHighlighted
MHID-5758484PMID: 353001732022Oxidative Medicine and Cellular Longevity
Yujie Li, Chengcheng Shen, Xin Zhou, Jianghe Zhang, Xiaoyue Lai, Yiming Zhang
Wound healing is a complex dynamic process involving a large number of biological events. Excessive oxidative stress is a key factor delaying wound healing. Hydrogen is an antioxidant, anti-inflammatory, and antiapoptotic medical gas with safety, effectiveness, and penetrability. However, the effects of local treatment of hydrogen on wound healing and its potential mechanisms remain unclear. In this
Animal Study
MHID-1210077PMID: 333568672021Canadian Journal of Physiology and Pharmacology
Jonatas E. Nogueira, Mateus R. Amorim, Ana P. Pinto, Alisson L. da Rocha, Adelino S. R. da Silva, Luiz G. S. Branco
Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H2) has emerged as a potent antioxidant, anti-inflammatory, and anti-apoptotic agent, but its act
Clinical TrialIn VitroHighlighted
MHID-7483898PMID: 338995412021Experimental Biology and Medicine
Yanhong Si, Hua Tian, Bingqing Dong, Ying Zhang, Yuanyuan Wen, Xiubin Jia, et al.
Oxidative stress and inflammation are closely related to atherosclerotic cardiovascular disease. It is established that hydrogen has significant protective effects on many diseases as a potential antioxidative and anti-inflammatory agent. The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo. An atherosclerosis model in vitro was constructed by ox-
In VitroHighlighted
MHID-7135279PMID: 345586532020Journal of Investigative Dermatology
Wei Fang, Luyan Tang, Guizhen Wang, Jinran Lin, Wanqing Liao, Weihua Pan, et al.
Oxidative stress is proven to be critical for the initiation and progression of vitiligo. Molecular hydrogen (H2) possesses potent antioxidant activity and has been shown to protect against various oxidative stresserelated diseases. In this study, we first investigated the effects and mechanisms of H2 in human melanocytes damaged by hydrogen peroxide. We initially found that H2 reduced intracellula
Animal StudyIn VitroHighlighted
MHID-6163351PMID: 305683872018World Journal of Gastroenterology
Karen Jackson, Noa Dressler, Rotem S Ben-Shushan, Ari Meerson, Tyler W. LeBaron, Snait Tamir
AIM To identify the effect of hydrogen-rich water (HRW) and electrolyzed-alkaline water (EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.
METHODS Mice were divided into four groups: (1) Regular diet (RD)/regular water (RW); (2) high-fat diet (HFD)/RW; (3) RD/EAW; and (4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers w
In VitroHighlighted
MHID-1525156PMID: 299011392018Molecular Medicine Reports
YU JIANG, GANG LIU, LI ZHANG, SHENG CHENG, CHUN LUO, YANG LIAO, et al.
The aim of the present study was to investigate the effects of combination therapy of LY294002, a specific inhibitor of phosphatidylinositol 3‑kinase (PI3K), with hydrogen‑rich saline on the proliferation and apoptosis of the non‑small cell lung cancer (NSCLC) A549 cell line and the mechanisms underpinning this. Excessive production of reactive oxygen species (ROS) may induce DNA mutations, DNA d
Animal StudyHighlighted
MHID-9957925PMID: 282930842017World Journal of Gastroenterology
Nai-Ying Shen, Jian-Bin Bi, Jing-Yao Zhang, Si-Min Zhang, Jing-Xian Gu, Kai Qu, et al.
AIM
To investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved.
METHODS
Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the mice received NS
Animal StudyHighlighted
MHID-4298510PMID: 285227972017Medical Science Monitor
Wen-Wen Dong, Yun-Qian Zhang, Xiao-Yan Zhu, Yan-Fei Mao, Xue-Jun Sun, Yu-Jian Liu, et al.
Background: Fibrotic change is one of the important reasons for the poor prognosis of patients with acute respiratory distress syndrome (ARDS). The present study investigated the effects of hydrogen-rich saline, a selective hydroxyl radical scavenger, on lipopolysaccharide (LPS)-induced pulmonary fibrosis.
Material/Methods: Male ICR mice were divided randomly into 5 groups: Control, LPS-treated p
Animal StudyHighlighted
MHID-5191051PMID: 281009592017Journal of Inflammation
Shaoqing Yu, Chuanliang Zhao, Na Che, Lin Jing, Rongming Ge
Background: It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute to elevating oxidative stress. Hydrogen, emerging as a novel antioxidant, has been proven effective in selectively reducing ROS in animals models of oxidative damage. We herein a
Animal StudyIn VitroHighlighted
MHID-7490434PMID: 287851462017World Journal of Gastroenterology
Ching-Pin Lin, Wen-Chen Chuang, Fung-Jou Lu, Chih-Yen Chen
AIM To investigate the effects of hydrogen-rich water (HRW) treatment on prevention of ethanol (EtOH)-induced early fatty liver in mice.
METHODS In vitro reduction of hydrogen peroxide by HRW was determined with a chemiluminescence system. Female mice were randomly divided into five groups: control, EtOH, EtOH + silymarin, EtOH + HRW and EtOH + silymarin + HRW. Each group was fed a Lieber-DeCarli
Animal Study
MHID-0745319PMID: 286562162017Molecular Medicine Reports
Jing Yang, Shujing Wu, Liqun Zhu, Jingjing Cai, Lu Fu
Cardiac fibrosis induced by sustained pressure overload contributes to heart failure. Oxidative stress serves an important role in cardiac remodeling and heart failure independent of etiological factors. The application of hydrogen as an antioxidant is a novel concept in disease treatment, however no studies as present have investigated the effects of hydrogen on cardiac fibrosis. In the present s
Animal StudyHighlighted
MHID-4053251PMID: 260900702015Oxidative Medicine and Cellular Longevity
Xing Chen, Qi Liu, Dawei Wang, Shihai Feng, Yongjian Zhao, Yun Shi, et al.
Objective. To explore the protective effects of hydrogen-rich saline on rats with smoke inhalation injury.
Methods. 36 healthy male Sprague-Dawley rats were randomly divided into 3 groups (𝑛= 12 per group): sham group (S), inhalation injury plus normal saline treatment group (I+NS), and inhalation injury plus hydrogen-rich saline treatment group (I+HS). 30 min after injury, normal saline and hydr
Animal StudyHighlighted
MHID-9762050PMID: 266686282015Experimental and Therapeutic Medicine
Xiaoyin Meng, Hongguang Chen, Guolin Wang, Yonghao Yu, Keliang Xie
Hydrogen has been reported to exert a therapeutic effect in several diseases due to its antioxidative, anti‑inflammatory and anti‑apoptotic properties. The aim of the present study was to investigate whether hydrogen‑rich saline treatment could attenuate ovarian damage induced by cisplatin. A total of 240 adult, virgin, female Sprague Dawley rats, weighing 180‑220 g, were randomly divided into fou
Animal StudyHighlighted
MHID-4748086PMID: 260479402015Journal of Translational Medicine
Song‑Xue Guo, Quan Fang, Chuan‑Gang You, Yun‑Yun Jin, Xin‑Gang Wang, Xin‑Lei Hu, et al.
Background: Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen species. This study investigated the potential protective effects of hydrogen against severe burn-induced early AKI in rats.
Methods: Severe burn were induced via immersing the sha
Animal StudyHighlighted
MHID-5761446PMID: 246182602014Journal of Cellular and Molecular Medicine
Sanhu Zhao, Yanyong Yang, Wen Liu, Zhiqiang Xuan, Shouming Wu, Shunfei Yu, et al.
Recent studies showed that hydrogen can be used as an effective radioprotective agent through scavenging free radicals. This study was under-
taken to evaluate the radioprotective effects of hydrogen on immune system in mice. H2 was dissolved in physiological saline using an apparatus
produced by our department. Spleen index and histological analysis were used to evaluate the splenic structural da
Plant Study
MHID-7838829PMID: 239510752013PLoS ONE
Jiqing Zeng, Mingyong Zhang, Xuejun Sun
Molecular hydrogen (H2) metabolism in bacteria and algae has been well studied from an industrial perspective because H2
is viewed as a potential future energy source. A number of clinical trials have recently reported that H2 is a therapeutic
antioxidant and signaling molecule. Although H2 metabolism in higher plants was reported in some early studies, its
biological effects remain unclear. In th
Clinical TrialAnimal StudyHighlighted
MHID-5560534PMID: 236101592013Journal of Lipid Research
Guohua Song, Min Li, Hui Sang, Liying Zhang, Xiuhong Li, Shutong Yao, et al.
We have found that hydrogen (dihydrogen; H 2 ) has benefi cial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H 2 -rich water (0.9–1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syn- drome. Serum analysis showed that consumption of H 2
Animal StudyHighlighted
MHID-3846502PMID: 359044492013Molecular Vision
Chun-xiao Yang, Hong Yan, Tian-bing Ding
Purpose: The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats.
Methods: Sprague-Dawley rat pups were divided into the following groups: control (Group A), selenite induced (Group B), and selenite plus hydrogen saline treated (Group C). Rat pups in Groups B and C received a singl
