In SilicoHighlighted
MHID-6447318PMID: 410089612025Antioxidants
Sumaiya Akhter Ria, Jintana Meesungnoen, Jean-Paul Jay-Gerin
(1) Background: Water, comprising about 70–80% of cellular mass, is the most abundant constituent of living cells. Upon exposure to ionizing radiation, water undergoes radiolysis, generating a variety of reactive species, including free radicals and molecular products. Among these, hydroxyl radicals (•OH) are particularly damaging due to their very high reactivity and their capacity to induce oxid
Literature Review
MHID-6342582PMID: 390776462024Reviews in Cardiovascular Medicine
Ram B. Singh, Zuzana Sumbalova, Ghizal Fatima, Viliam Mojto, Jan Fedacko, Alex Tarnava, et al.
Diet and lifestyle choices, notably the Western-type diet, are implicated in oxidative stress and inflammation, factors that elevate the risk of cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM). In contrast, the Mediterranean of diet, rich in antioxidants, appears to have protective effects against these risks. This article highlights the dual role of diet in generating molecular
Animal StudyHighlighted
MHID-5098246PMID: 382641422024Sleep Advances
Scott M. Vincent, Melika Madani, Dante Dikeman, Kyle Golden, Naomi Crocker, Cameron Jackson, et al.
Study Objectives: Sleep loss contributes to various health issues and impairs neurological function. Molecular hydrogen has recently gained popularity as a nontoxic ergogenic and health promoter. The effect of molecular hydrogen on sleep and sleep-related neural systems remains unexplored. This study investigates the impact of hydrogen-rich water (HRW) on sleep behavior and neuronal acti- vation i
Animal StudyHighlighted
MHID-65602132024
Yuxi Wei
Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent upper airway collapse during sleep, leading to chronic intermittent hypoxia (CIH) that can cause oxidative stress and chronic inflammation that lead to cardiovascular disease (CVD). Although continuous positive airway pressure (CPAP) treatment is the gold standard for OSA treatment, it has little or no benefit in reduc
Animal StudyHighlighted
MHID-6941053PMID: 378959072023Pharmaceuticals
Seyedeh Elnaz Nazari, Alex Tarnava, Nima Khalili-Tanha, Mahdieh Darroudi, Ghazaleh Khalili-Tanha, Amir Avan, et al.
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial. This study aimed to investigate the therapeutic potential of hydrogen-rich water (HRW) on muscle atrophy in a unilateral hind limb immobilization model. Thirty-six male Balb/C mice were divided into control (without
Clinical TrialObservational StudyHighlighted
MHID-7657388PMID: 378737712023Diseases
Ram B. Singh, Alex Tarnava, Ghizal Fatima, Jan Fedacko, Viliam Mojto, Tyler W. LeBaron
Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and chronic respiratory failure. This study aims to determine if hydrogen-rich water (HRW) can enhance oxygen saturation among patients with chronic lung diseases. Methods: Ten patients with chronic lung diseases due to COPD (n = 7), bronchi
Animal StudyHighlighted
MHID-0513892PMID: 351161142022World Journal of Gastrointestinal Oncology
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W. LeBaron
Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H2) has been re- cognized for its antioxidant and anti-inflammatory effects, with resear
Opinion PieceHighlighted
MHID-62678002021Canadian Journal of Physiology and Pharmacology
Shigeo Ohta, Tyler W. LeBaron
The authors of the “Discussion” (Falster et al. 2021) have responded to our article entitled: “Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study”. Hydrogen (H2) medicine is being developed as an orthodox science. In this Reply, we would like to elaborate on the effects of H2-infused water and the scientific understand
Observational StudyHighlighted
MHID-5864798PMID: 347652122021Clinical Case Reports
Ram B. Singh, Ghazi Halabi, Ghizal Fatima, Richa H. Rai, Alexander T. Tarnava, Tyler W. LeBaron
Administration of molecular hydrogen dissolved in water to patient with COVID-19-like symptoms may improve oxygen levels and exercise capacity.
Literature Review
MHID-6029476PMID: 346464232021Oxidative Medicine and Cellular Longevity
Duried Alwazeer, Franky Fuh-Ching Liu, Xiao Yu Wu, Tyler W. LeBaron
COVID-19 is a widespread global pandemic with nearly 185 million confirmed cases and about four million deaths. It is caused by an infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which primarily affects the alveolar type II pneumocytes. The infection induces pathological responses including increased inflammation, oxidative stress, and apoptosis. This situation result
Literature Review
MHID-3461972PMID: 309702152019Canadian Journal of Physiology and Pharmacology
Tyler W. LeBaron, Ismail Laher, Branislav Kura, Jan Slezak
H2 has been clinically demonstrated to provide antioxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic high-intensity exercise in elite athletes, or sporadic bouts of exercise (i.e. noxious exercise) in unt
Clinical TrialObservational StudyHighlighted
MHID-8766045PMID: 202169472010Journal of Clinical Biochemistry and Nutrition
Atsunori Nakao, Yoshiya Toyoda, Prachi Sharma, Malkanthi Evans, Najla Guthrie
Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5–2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic
