Observational StudyHighlighted
MHID-7483719PMID: 329948212020Oncology Letters
Junji Akagi, Hideo Baba
As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial activators exhibit synergistic effects with nivolumab, the current study investigated whether hydrogen gas also affects the clinical outcomes of nivolumab. A total of 42 of 56 patients with lung cance
Clinical TrialHighlighted
MHID-0038979PMID: 324700222020PLoS ONE
Toru Ishibashi, Kosuke Kawamoto, Kasumi Matsuno, Genki Ishihara, Takamichi Baba, Nobuaki Komori
Background: Measurement of the reactive hyperemia index (RHI) using peripheral arterial tonometry (PAT) has shown benefits in the evaluation of vascular endothelial function and prediction of cardiovascular disease prognosis. Thus, it is important to examine the factors that promote the RHI. In this study, we aimed to investigate the effect of molecular hydrogen (H2) on reactive hyperemia-PAT of t
Animal Study
MHID-1878579PMID: 322460952020Scientific Reports
Yuki Kobayashi, Ryoichi Imamura, Yoshihisa Koyama, Makoto Kondo, Hikaru Kobayashi, Norio Nonomura, et al.
We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant kidney
Literature ReviewHypothesis
MHID-1633113PMID: 321896692020Medical Gas Research
Shin-ichi Hirano, Yusuke Ichikawa, Ryosuke Kurokawa, Yoshiyasu Takefuji, Fumitake Satoh
It has been revealed that the cause of senescence and diseases is associated with the reactive oxygen species “hydroxyl radicals” (·OH). Se- nescence and diseases may be overcome as long as we can scavenge •OH mostly produced in mitochondria. It is one and only one “molecular hydrogen” (H2) that can both penetrate into the mitochondria and scavenge the •OH. The H2 in the body can function in disea
Clinical TrialHighlighted
MHID-21966452019Canadian Journal of Physiology and Pharmacology
Toshio Mikami, Kohei Tano, Hosung Lee, Hyowon Lee, Jonghyuk Park, Fumiaki Ohta, et al.
Acute physical exercise increases reactive oxygen species in skeletal muscle, leading to tissue damage and fatigue. Molecular hydrogen (H2) acts as a therapeutic antioxidant directly or indirectly by inducing anti-oxidative enzymes. Here, we examined the effects of drinking H2 water (H2-infused water) on psychometric fatigue and endurance capacity in a randomized, double-blind, placebo-controlled
Literature ReviewMechanisms Review
MHID-7292103PMID: 310571052019Current Pharmaceutical Design
Toru Ishibashi
Background: Molecular hydrogen (H2) is now recognized as a therapeutic gas for the treatment of numerous diseases including neurodegenerative diseases, metabolic disorders, and inflammatory diseases. Non- polar, neutral H2 is assumed to have health benefits facilitated by its passive diffusion across the human body immediately after administration and is considered a safe therapeutic inert gas tha
Clinical TrialHighlighted
MHID-4871667PMID: 309188322019Journal of Lifestyle Medicine
Tyler W. LeBaron, Abigail J. Larson, Shigeo Ohta, Toshio Mikami, Jordon Barlow, Josh Bulloch, et al.
Background: Clinical studies have reported hydrogen-rich water (HRW) to have therapeutic and ergogenic effects. The aim of this study was to determine the effect of acute supplementation with HRW on exercise performance as measured by VO2, respiratory exchange ratio (RER), heart rate (HR), and respiratory rate (RR).
Methods: Baseline levels of all exercise indices were determined in nineteen (4 f
Observational StudyHighlighted
MHID-3602984PMID: 312492542019Medical Gas Research
Ryoko Asada, Yasukazu Saitoh, Nobuhiko Miwa
Hydrogen-dissolved water has been shown to improve diverse oxidation stress-related diseases, which drove us to examine effects of hydrogen-rich water on oxidation stress-related skin troubles and lipid-metabolism markers. The purpose of this study is whether the dissolved hydrogen in hydrogen-rich water was kept even after boiling, and whether hydrogen-bath utilization improves cosmetic effects s
Clinical TrialObservational StudyHighlighted
MHID-0370162PMID: 305427402019Oncology Reports
Junji Akagi, Hideo Baba
Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, the present study investigated whether it restores exhausted CD8+ T cells to impr
Literature Review
MHID-8766047PMID: 311002032019Canadian Journal of Physiology and Pharmacology
Mami Noda, Yuya Uemura, Yusuke Yoshii, Taichi Horita, Shota Takemi, Ichiro Sakata, et al.
Molecular hydrogen (H2) showed protection against various kinds of oxidative stress-
related diseases. First it was reported that the mechanism of therapeutic effects of H2 was
anti-oxidative effect due to inhibition of most cytotoxic reactive oxygen species (ROS),
hydroxy radical (•OH). However, after chronic administration of H2 in drinking water,
oxidative stress-induced nerve injury is signifi
MHID-4878784PMID: 292931742018Shock
Mitsunori Ikeda, Kentaro Shimizu, Hiroshi Ogura, Takashi Kurakawa, Eiji Umemoto, Daisuke Motooka, et al.
Bacterial translocation is a major cause of multiple organ dysfunction syndrome in critical illness, and its management is an important therapeutic strategy. In this study, we focused on the key factors responsible for bacterial translocation including the intestinal microbiome and investigated the impact of molecular hydrogen therapy as a countermeasure against bacterial translocation in a murine
Observational Study
MHID-8360107PMID: 293215092018Scientific Reports
Masaaki Nakayama, Noritomo Itami, Hodaka Suzuki, Hiromi Hamada, Ryo Yamamoto, Kazumasa Tsunoda, et al.
Recent studies have revealed unique biological characteristics of molecular hydrogen (H2) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering an H2 (30–80 ppb)-enriched dialysis solution by water electrolysis, and conducted a non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocate
In VitroIn SilicoHighlighted
MHID-67149392018PLoS ONE
Anzu Suzuki, Mikako Ito, Tomonori Hamaguchi, Hiroshi Mori, Yuka Takeda, Ryuko Baba, et al.
Oral administration of hydrogen water ameliorates Parkinson’s disease (PD) in rats, mice, and humans. We previously reported that the number of putative hydrogen-producing bacte- ria in intestinal microbiota is low in PD compared to controls. We also reported that the amount of hydrogen produced by ingestion of lactulose is low in PD patients. The decreased hydrogen production by intestinal microb
Clinical Trial
MHID-0476956PMID: 307136662018Medical Gas Research
Masaaki Hirayama, Mikako Ito, Tomomi Minato, Asako Yoritaka, Tyler W. LeBaron, Kinji Ohno
Hyposmia is one of the earliest and the most common symptoms in Parkinson’s disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and urinar
Animal StudyIn SilicoHighlighted
MHID-9900832PMID: 294242532018
Hiroshi Nishiwaki, Mikako Ito, Shuto Negishi, Sayaka Sobue, Masatoshi Ichihara, Kinji Ohno
Background: Molecular hydrogen exerts its effect on multiple pathologies, including oxidative stress, inflammation, and apoptosis. However, its molecular mechanisms have not been fully elucidated. In order to explore the effects of molecular hydrogen, we meta-analyzed gene expression profiles modulated by molecular hydrogen.
Methods: We performed microarray analysis of the mouse liver with or wit
Clinical Trial
MHID-9222881PMID: 294974852018Medical Gas Research
Kei Mizuno, Akihiro T. Sasaki, Kyoko Ebisu, Kanako Tajima, Osami Kajimoto, Junzo Nojima, et al.
Health and a vibrant life are sought by everyone. To improve quality of life (QOL), maintain a healthy state, and prevent various diseases, evaluations of the effects of potentially QOL-increasing factors are important. Chronic oxidative stress and inflammation cause deteriora- tions in central nervous system function, leading to low QOL. In healthy individuals, aging, job stress, and cognitive lo
Clinical TrialHighlighted
MHID-6786572PMID: 307136692018Medical Gas Research
Yoshinori Tanaka, Yasuhiro Saihara, Kyoko Izumotani, Hajime Nakamura
In Japan, alkaline electrolyzed water (AEW) apparatus have been approved as a medical device. And for the patients with gastrointestinal symptoms, drinking AEW has been found to be effective in relieving gastrointestinal symptoms. But some users of AEW apparatus do not have abdominal indefinite complaint. Little attention has been given to the benefit for the users which have no abdominal indefini
Clinical TrialAnimal StudyHighlighted
MHID-5385411PMID: 291106152018Current Alzheimer Research
Kiyomi Nishimaki, Takashi Asada, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, et al.
Background: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant.
Objective: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI
MHID-8305949PMID: 268666502017Redox Report
Satoru Hasegawa, Mikako Ito, Mayu Fukami, Miki Hashimoto, Masaaki Hirayama, Kinji Ohno
Duchenne muscular dystrophy (DMD) is a devastating muscle disease caused by a mutation in DMD encoding dystrophin. Oxidative stress accounts for dystrophic muscle pathologies in DMD. We examined the effects of molecular hydrogen in mdx mice, a model animal for DMD.
Methods: The pregnant mother started to take supersaturated hydrogen water (>5 ppm) ad libitum from E15.5 up to weaning of the offspri
Literature ReviewHighlighted
MHID-7292601PMID: 287518022017Journal of Clinical Biochemistry and Nutrition
Kenji Dohi, Kazue Satoh, Kazuyuki Miyamoto, Shusuke Momma, Kenichiro Fukuda, Ryo Higuchi, et al.
Oxidative stress caused by reactive oxygen species is considered a major mediator of tissue and cell injuries in various neuronal conditions, including neurological emergencies and neurodegenerative diseases. Molecular hydrogen is well characterized as a scavenger of hydroxyl radicals and peroxynitrite. Recently, the neuroprotective effects of treatment with molecular hydrogen have been reported i
