Clinical TrialHighlighted
MHID-96660182025Journal of Physical Education and Sport
Jakub Krejčí, Michal Botek, Shigeo Ohta, Klara Botkova, Andrew McKune
Problem Statement: Effective inter-match recovery plays a crucial role in preserving performance and preventing injuries in well-trained soccer players. In this context, molecular hydrogen has attracted increasing attention in sports science due to its selective antioxidative, anti-inflammatory, and cell-signaling properties that may facilitate recovery. Among the various administration methods, h
Clinical TrialHighlighted
MHID-1036598PMID: 399231332025Medical Gas Research
Pavel Grepl, Michal Botek, Jakub Krejčí, Andrew McKune
Initially, molecular hydrogen was considered a physiologically inert and non-functional gas. However, experimental and clinical studies have shown that molecular hydrogen has anti-inflammatory, anti-apoptotic, and strong selective antioxidant effects. This study aimed to evaluate the effects of 60 minutes of molecular hydrogen inhalation on respiratory gas analysis parameters using a randomized, d
Clinical Trial
MHID-98854012024Science & Sports
S.H. Ryu, J.H. Oh, K.W. Noh, S. Park
Summary
Objective: This study aimed to contribute towards improving athletic performance by comparing the effects of highly concentrated hydrogen intake before and during exercise on soccer players’ metabolic and athletic performance.
Materials and methods: This study followed a single-blind crossover design involving 10 male college soccer players. Before this experiment, the Vmax measurement a
Clinical Trial
MHID-8109346PMID: 390647852024Nutrients
Gengxin Dong, Haiyan Liu, Yunji Chen, Dapeng Bao, Wentao Xu, Junhong Zhou
Background: The diversity of blood biomarkers used to assess the metabolic mechanisms of hydrogen limits a comprehensive understanding of its effects on improving exercise performance. This study evaluated the impact of hydrogen-rich gas (HRG) on metabolites following sprint-interval exercise using metabolomics approaches, aiming to elucidate its underlying mechanisms of action.
Methods: Ten heal
Clinical Trial
MHID-0740382PMID: 386986242024International Journal of Sports Medicine
Gengxin Dong, Jianxin Wu, Yinglu Hong, Qian Li, Meng Liu, Guole Jiang, et al.
Hydrogen, as an antioxidant, may have the potential to mitigate fatigue and improve selected oxidative stress markers induced by strenuous exercise. This study focused on a previously unexplored approach involving pre-exercise inhalation of hydrogen-rich gas (HRG). Twenty-four healthy adult men first completed pre-laboratories to determine maximum cycling power (Wmax) and maximum cycling time (Tma
Clinical TrialHighlighted
MHID-7865618PMID: 394347212024Frontiers in Physiology
Kaixiang Zhou, Chaoqun Yuan, Zhangyuting Shang, Wenhui Jiao, Yubo Wang
Background: Exercise-induced oxidative stress and inflammation can impair muscular function in humans. The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) highlight its potential to be as an effective nutritional supplement to support muscular function performance in healthy adults. However, the effects of H2 supplementation on muscular endurance performance in trained indivi
Clinical TrialHighlighted
MHID-71472332023Česká a Slovenská Oftalmologie
Mgr. Eliška Najmanová, Ph.D., H. Manethová, M. Botek, Doc. RNDr. František Pluháček, Ph.D.
Purposes: The primary aim of the study was to assess the response of intraocular pressure (IOP) to the acute ingestion of hydrogen-rich water (HRW) compared to hydrogen-free water (placebo) in healthy subjects. The effect of HRW intake on central corneal thickness (CCT) was also monitored.
Subjects and Methods: Twenty-four healthy volunteers (5 men, 19 women) aged between 20 and 33 were included i
Clinical Trial
MHID-7655607PMID: 365385542022PLOS ONE
Michal Valenta, Michal Botek, Jakub Krejčí, Andrew McKune, Barbora Sládečková, Filip Neuls, et al.
Purpose This study investigated the effects of acute, pre-exercise, hydrogen rich water (HRW) ingestion on running time to exhaustion at maximal aerobic speed in trained track and field runners.
Methods Twenty-four, male runners aged 17.5 ± 1.8 years, with body mass index = 21.0 ± 1.3 kgm-2, and maximal oxygen uptake = 55.0 ± 4.6 mlkg-1min-1 (mean ± standard deviation) participated in this ran
Clinical Trial
MHID-7556506PMID: 352768672022Nutrients
Michal Botek, Deepesh Khanna, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, et al.
Hydrogen-rich water (HRW) supplementation has been shown to have an antifatigue effect across different modes of exercise. However, its effect on repeated sprint performance is unknown. The aim of this study was to assess the effect of pre-exercise HRW consumption on repeated sprint performance, lactate, and perceptual responses using a repeated sprint protocol. This randomized, double blinded, pl
Clinical TrialHighlighted
MHID-0754862PMID: 361246532022American Journal of Clinical Nutrition
Xiang Lv, Yuanfeng Lu, Guoyong Ding, Xiao Li, Xinxin Xu, Aihua Zhang, et al.
Background: Alcohol-induced hangover represents a significant, yet understudied, global hazard and a large socioeconomic burden. Objective: The aim of this study was to investigate the effects of hydrogen on relieving drinking and hangover symptoms in 20 healthy volunteers.
Methods: In this pilot, randomized, double-blinded, placebo- controlled, matched, crossover interventional trial, participan
Clinical Trial
MHID-8601801PMID: 340791722021Biology of Sport
Rafael Timón, Guillermo Olcina, Adrian González-Custodio, Marta Camacho-Cardenosa, Alba Camacho-Cardenosa, Ismael Martínez Guardado
Hydrogen-rich water (HRW) is used as a supplement to improve performance and reduce fatigue in athletes. However, the potentially beneficial effects of HRW intake could be mediated by the training status of athletes. The purpose of the study was to analyse the ergogenic effect of intake of HRW for one week on aerobic and anaerobic performance, both in trained and untrained individuals. Thirty-seve
Clinical TrialAnimal StudyHighlighted
MHID-8498103PMID: 337420602021Scientific Reports
Miyuki Kubota, Motoko Kawashima, Sachiko Inoue, Toshihiro Imada, Shigeru Nakamura, Shunsuke Kubota, et al.
The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear fluids; however, to our knowledge, no agent that treats both pathologies simultaneously is available. Molecular hydrogen (H2) is known to be effective
Clinical Trial
MHID-2960170PMID: 333805812020Medical Gas Research
Yudai Shibayama, Shohei Dobashi, Takaaki Arisawa, Tamotsu Fukuoka, Katsuhiro Koyama
Molecular hydrogen has been suggested to have a cytoprotective effect on the whole body and to enhance exercise performances. However, the effect of hydrogen-rich gas mixture (HG) inhalation on physiological responses has been poorly investigated. We examined the impact of acute HG inhalation on subsequent oxidative stress, muscle damage, and exercise performances during the recovery period after
Clinical Trial
MHID-2512221PMID: 315745442019International Journal of Sports Medicine
Michal Botek, Jakub Krejčí, Andrew J. McKune, Barbora Sládečková, Nenad Naumovski
The potential anti-fatigue and performance benefits of hydrogen rich water (HRW) have resulted in increased research interest over the past 5 years. The aim of this study was to assess physiological and perceptual responses to an incremental exercise protocol after administration of 600 ml HRW within 30 min before exercise. This randomized, double blinded placebo-controlled cross over study includ
Clinical TrialHighlighted
MHID-4871667PMID: 309188322019Journal of Lifestyle Medicine
Tyler W. LeBaron, Abigail J. Larson, Shigeo Ohta, Toshio Mikami, Jordon Barlow, Josh Bulloch, et al.
Background: Clinical studies have reported hydrogen-rich water (HRW) to have therapeutic and ergogenic effects. The aim of this study was to determine the effect of acute supplementation with HRW on exercise performance as measured by VO2, respiratory exchange ratio (RER), heart rate (HR), and respiratory rate (RR).
Methods: Baseline levels of all exercise indices were determined in nineteen (4 f
Clinical Trial
MHID-9868845PMID: 285605192018Irish Journal of Medical Science
D. Korovljev, T. Trivic, P. Drid, S. M. Ostojic
Background: Molecular hydrogen (H2) effectively treats obesity-related disorders in animal models, yet no studies have investigated the effectiveness and safety of H2 for improving biomarkers of obesity in humans.
Aim: In this double blind, placebo-controlled, crossover pilot trial, we evaluated the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in ten
Clinical Trial
MHID-9222881PMID: 294974852018Medical Gas Research
Kei Mizuno, Akihiro T. Sasaki, Kyoko Ebisu, Kanako Tajima, Osami Kajimoto, Junzo Nojima, et al.
Health and a vibrant life are sought by everyone. To improve quality of life (QOL), maintain a healthy state, and prevent various diseases, evaluations of the effects of potentially QOL-increasing factors are important. Chronic oxidative stress and inflammation cause deteriora- tions in central nervous system function, leading to low QOL. In healthy individuals, aging, job stress, and cognitive lo
Clinical TrialObservational Study
MHID-7186474PMID: 230310792012Medical Gas Research
Toru Ishibashi, Bunpei Sato, Mariko Rikitake, Tomoki Seo, Ryosuke Kurokawa, Yuichi Hara, et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in the pathogenesis of RA. Recently, molecular hydrogen (H2) was demonstrated to be a selective scavenger for the hydroxyl radical. Also, the method to prepare water containing extrem
Clinical Trial
MHID-3851590PMID: 225208312012Medical Gas Research
Kosuke Aoki, Atsunori Nakao, Takako Adachi, Yasushi Matsui, Shumpei Miyakawa
Background: Muscle contraction during short intervals of intense exercise causes oxidative stress, which can play a role in the development of overtraining symptoms, including increased fatigue, resulting in muscle microinjury or inflammation. Recently it has been said that hydrogen can function as antioxidant, so we investigated the effect of hydrogen-rich water (HW) on oxidative stress and muscl
Clinical TrialObservational Study
MHID-1491336PMID: 199307632010British Journal of Nutrition
Min Li, Jian-Hua Piao, Yuan Tian, Wei-Dong Li, Ke-Ji Li, Xiao-Guang Yang
Consumption of resistant starch (RS)-enriched foods is associated with decrease in the postprandial glycaemic and insulinaemic responses, accompanied by the production of fermentation-related gases in the large bowel. The present study aimed to determine the postprandial glycaemic and insulinaemic responses to the GM RS-enriched rice and the fermentation-related production of H2 in young and healt
