Clinical TrialHighlighted
MHID-9198954PMID: 397039112024PeerJ
Yuqi Zhao, Chaoqun Li, Shi Zhou, Zhiguang Xu, Xin Huang, Li Wen
Background: Inhalation of hydrogen gas (H2) as an antioxidant supplement may alleviate exercise-induced oxidative damage and protect post-exercise hydrogen peroxide signaling, which may help mediate beneficial exercise adaptation. The aims of this study were to determine the effects of H2 inhalation on plasma nitric oxide (NO) level and its synthesis precursor in professional athletes.
Methods: A
Clinical TrialAnimal StudyHighlighted
MHID-3437190PMID: 391167822024Biomedicine & Pharmacotherapy
Bing Xie, Yong Wang, Yun Lu, Mengmeng Wang, Rongji Hui, Hailei Yu, et al.
The gut-brain axis mediates the interaction pathway between microbiota and opioid addiction. In recent years, many studies have shown that molecular hydrogen has therapeutic and preventive effects on various diseases. This study aimed to investigate whether molecular hydrogen could serve as pharmacological intervention agent to reduce risks of reinstatement of opioid seeking and explore the mechan
Clinical TrialHighlighted
MHID-64165942023Processes
Subham Sharma, Yundeok Kim, Johny Bajgai, Md. Habibur Rahman, Yun Ju Jeong, Seong Hoon Goh, et al.
Chronic constipation is a common symptom-based disorder that affects patient quality of life. Electrolyzed hydrogen-rich alkaline reduced water (EHARW) helps treat gastrointestinal disorders owing to its various bioactive properties. This single-arm, open-labelled study aimed to investigate the improvement of EHARW (pH 9.5; H2 ≈0.5 mg/L) in chronic constipation patients. Thirty patients with chron
Clinical TrialHighlighted
MHID-1277179PMID: 373719712023Antioxidants
Md. Habibur Rahman, Johny Bajgai, Subham Sharma, Eun-Sook Jeong, Seong Hoon Goh, Yeon-Gyu Jang, et al.
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer’s disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants, including those who dropped out (5%), were screened and enrolled. The selected
Clinical TrialObservational StudyHighlighted
MHID-99610682021Journal of Education, Health and Sport
Yurii Rohovyi, Volf Tsitrin, Yula Bilooka, Ludmila Arkchipova, Vyacheslav Bilookiy
Aim. To find out a pathophysiological protective role of influence of molecular hydrogen on a functional condition of a proximal tubule of kidneys at an irritable bowel syndrome.
Materials and methods. 60 patients with irritable bowel syndrome were examined. Men - 18, women - 42 aged from 28 to 62 years. Of which: with irritable bowel syndrome with constipation were - 28 patients, irritable bowel
Clinical TrialHighlighted
MHID-68343622020临床耳鼻咽喉头颈外科杂志 (J Clin Otorhinolaryngol Head Neck Surg (China))
金玲, 范锴, 张熙, 赵义华, 葛琴, 王扬, et al.
Objective: To observe the effect of hydrogen-rich saline on the concentration of nitric oxide in the nose, and to explore the mechanism of its treatment of allergic rhinitis. Method: Twenty patients with moderate to severe persistent allergic rhinitis were enrolled in a randomized, double-blind, self-controlled study. The nasal cavity was lavaged with hydrogen-rich normal saline and normal saline,
Clinical Trial
MHID-2512221PMID: 315745442019International Journal of Sports Medicine
Michal Botek, Jakub Krejčí, Andrew J. McKune, Barbora Sládečková, Nenad Naumovski
The potential anti-fatigue and performance benefits of hydrogen rich water (HRW) have resulted in increased research interest over the past 5 years. The aim of this study was to assess physiological and perceptual responses to an incremental exercise protocol after administration of 600 ml HRW within 30 min before exercise. This randomized, double blinded placebo-controlled cross over study includ
Clinical Trial
MHID-0476956PMID: 307136662018Medical Gas Research
Masaaki Hirayama, Mikako Ito, Tomomi Minato, Asako Yoritaka, Tyler W. LeBaron, Kinji Ohno
Hyposmia is one of the earliest and the most common symptoms in Parkinson’s disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and urinar
Clinical TrialHighlighted
MHID-1221967PMID: 267838402015Antioxidants
Tetsuji Azuma, Mayu Yamane, Daisuke Ekuni, Yuya Kawabata, Kota Kataoka, Kenta Kasuyama, et al.
Oxidative stress is involved in the pathogenesis of periodontitis. A reduction of oxidative stress by drinking hydrogen-rich water (HW) might be beneficial to periodontal health. In this pilot study, we compared the effects of non-surgical periodontal treatment with or without drinking HW on periodontitis. Thirteen patients (3 women, 10 men) with periodontitis were divided into two groups: The con
Clinical TrialAnimal StudyHighlighted
MHID-5560534PMID: 236101592013Journal of Lipid Research
Guohua Song, Min Li, Hui Sang, Liying Zhang, Xiuhong Li, Shutong Yao, et al.
We have found that hydrogen (dihydrogen; H 2 ) has benefi cial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H 2 -rich water (0.9–1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syn- drome. Serum analysis showed that consumption of H 2
Clinical TrialHighlighted
MHID-38265332012Mayo Clinic Proceedings
Sergej M. Ostojic, MD, PhD
Metabolic acidosis is a clinical disturbance characterized by low pH in body tissues and blood and a variety of neuromuscular and cardiorespiratory responses.1 Besides treating the initial disorder, the main goal for patients with acidosis is to increase the systemic pH with alkalizing agents, such as bicarbonates2; however, adverse reactions linked to the administration of sodium bicarbonate (eg,
Clinical TrialObservational Study
MHID-7186474PMID: 230310792012Medical Gas Research
Toru Ishibashi, Bunpei Sato, Mariko Rikitake, Tomoki Seo, Ryosuke Kurokawa, Yuichi Hara, et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in the pathogenesis of RA. Recently, molecular hydrogen (H2) was demonstrated to be a selective scavenger for the hydroxyl radical. Also, the method to prepare water containing extrem
Clinical TrialHighlighted
MHID-2481572PMID: 221466742011Medical Gas Research
Mikako Ito, Tohru Ibi, Ko Sahashi, Masashi Ichihara, Masafumi Ito, Kinji Ohno
Background: Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, hemodialysis, metabolic syndrome, radiotherapy for liver cancer, and brain stem infarction. Hydrogen effects are ascribed to specific radical-scavenging
