鼻呼出一氧化氮在富氢盐水灌洗鼻腔治疗变应性鼻炎中的变化及意义

Abstract

Objective: To observe the effect of hydrogen-rich saline on the concentration of nitric oxide in the nose, and to explore the mechanism of its treatment of allergic rhinitis. Method: Twenty patients with moderate to severe persistent allergic rhinitis were enrolled in a randomized, double-blind, self-controlled study. The nasal cavity was lavaged with hydrogen-rich normal saline and normal saline, and the nasal nitric oxide (nNO) value was tested weekly. Result: The test value of nNO was correlated with the diagnosis and curative effect of allergic rhinitis. The difference of nNO test values before and after treatment of the two lavage fluids was statistically significant (P<0.01). Conclusion: Hydrogen-rich saline lavage can cause nNO change in nasal cavity which may be used in the treatment of allergic rhinitis.

Study details

Article type

Original Research

Disease / injury model

Allergic rhinitis (moderate to severe, persistent)

Duration

4 weeks

Dose comparison

Only one concentration (saturated hydrogen-rich saline) was used; no dose comparison.

Dose-dependent effect

No

Outcome

Positive

Findings

Hydrogen-rich saline nasal lavage significantly reduced nasal nitric oxide (nNO) levels in patients with moderate to severe persistent allergic rhinitis compared to normal saline, and was associated with improved clinical symptoms. The change in nNO was highly correlated with treatment efficacy, suggesting hydrogen-rich saline as a promising local therapy for allergic rhinitis.