Clinical TrialHighlighted
MHID-96660182025Journal of Physical Education and Sport
Jakub Krejčí, Michal Botek, Shigeo Ohta, Klara Botkova, Andrew McKune
Problem Statement: Effective inter-match recovery plays a crucial role in preserving performance and preventing injuries in well-trained soccer players. In this context, molecular hydrogen has attracted increasing attention in sports science due to its selective antioxidative, anti-inflammatory, and cell-signaling properties that may facilitate recovery. Among the various administration methods, h
Clinical TrialHighlighted
MHID-8924760PMID: 408680532025Biomedicines
Takafumi Maruyama, Dai Ishikawa, Rina Kurokawa, Hiroaki Masuoka, Kei Nomura, Mayuko Haraikawa, et al.
Background/Objective: Dysbiosis is implicated in the pathogenesis of ulcerative colitis. Hydrogen has been reported to promote intestinal microbiota diversity and suppress ulcerative colitis progression in mice models. In this study, we investigated changes in the intestinal microbiota, therapeutic effects, and safety of hydrogen inhalation in patients with ulcerative colitis.
Methods: In this ra
Clinical TrialHighlighted
MHID-5491717PMID: 412043202025Trials
Victoria Habet, Tysen DeWaard, Krislyn M. Boggs, Alix Fetch, Bao Nguyen Puente, Lynn A. Sleeper, et al.
Background: Extracorporeal cardiopulmonary resuscitation (ECPR) improves survival for patients experiencing refractory cardiac arrest but is often associated with severe ischemia-reperfusion injury (IRI). Hydrogen gas (H2) has demonstrated promising preclinical efficacy in reducing IRI. The Hydrogen-FAST trial investigates the feasibility and safety of inhaled hydrogen gas as an adjunctive therapy
Clinical TrialHighlighted
MHID-9166764PMID: 408269302025Medical Gas Research
Yu Hong Gao, Jun Chen, Hua Zhong, Qiang Zhao
Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, and antifibrotic effects and has potential applications in disease management, its impact on sleep disorders remains unclear. This single-blind, randomized controlled clinical trial from September 2022 to July 2023 at the Second Medical Center of the PLA General Hospital and the Affilia
Clinical TrialHighlighted
MHID-1036598PMID: 399231332025Medical Gas Research
Pavel Grepl, Michal Botek, Jakub Krejčí, Andrew McKune
Initially, molecular hydrogen was considered a physiologically inert and non-functional gas. However, experimental and clinical studies have shown that molecular hydrogen has anti-inflammatory, anti-apoptotic, and strong selective antioxidant effects. This study aimed to evaluate the effects of 60 minutes of molecular hydrogen inhalation on respiratory gas analysis parameters using a randomized, d
Clinical Trial
MHID-8109346PMID: 390647852024Nutrients
Gengxin Dong, Haiyan Liu, Yunji Chen, Dapeng Bao, Wentao Xu, Junhong Zhou
Background: The diversity of blood biomarkers used to assess the metabolic mechanisms of hydrogen limits a comprehensive understanding of its effects on improving exercise performance. This study evaluated the impact of hydrogen-rich gas (HRG) on metabolites following sprint-interval exercise using metabolomics approaches, aiming to elucidate its underlying mechanisms of action.
Methods: Ten heal
Clinical Trial
MHID-7502024PMID: 414014412024Canadian Journal of Physiology and Pharmacology
Pavel Grepl, Jakub Krejčí, Andrew McKune, Michal Botek
Molecular hydrogen has gained attention for its potential antioxidant, anti-inflammatory, and ergogenic effects. However, its impact on blood oxygen saturation and autonomic cardiac regulation under resting conditions remains unclear. This randomized, double-blind, placebo-controlled crossover study investigated the effects of a 60-minute molecular hydrogen inhalation on oxygen saturation and hear
Clinical Trial
MHID-0740382PMID: 386986242024International Journal of Sports Medicine
Gengxin Dong, Jianxin Wu, Yinglu Hong, Qian Li, Meng Liu, Guole Jiang, et al.
Hydrogen, as an antioxidant, may have the potential to mitigate fatigue and improve selected oxidative stress markers induced by strenuous exercise. This study focused on a previously unexplored approach involving pre-exercise inhalation of hydrogen-rich gas (HRG). Twenty-four healthy adult men first completed pre-laboratories to determine maximum cycling power (Wmax) and maximum cycling time (Tma
Clinical TrialHighlighted
MHID-9198954PMID: 397039112024PeerJ
Yuqi Zhao, Chaoqun Li, Shi Zhou, Zhiguang Xu, Xin Huang, Li Wen
Background: Inhalation of hydrogen gas (H2) as an antioxidant supplement may alleviate exercise-induced oxidative damage and protect post-exercise hydrogen peroxide signaling, which may help mediate beneficial exercise adaptation. The aims of this study were to determine the effects of H2 inhalation on plasma nitric oxide (NO) level and its synthesis precursor in professional athletes.
Methods: A
Clinical TrialHighlighted
MHID-1852029PMID: 385323732024BMC Women's Health
Menekşe Nazlı Aker, İlknur M. Gönenç, Dilan Çalişici, Menekşe Bulut, Duried Alwazeer, Tyler W. LeBaron
Background Premenstrual syndrome (PMS) consists of psychiatric or somatic symptoms negatively affecting the daily life. PMS treatment can involve the use of complementary-alternative approaches. Hydrogen-rich water (HRW) has antioxidant and anti-inflammatory properties that may treat PMS. This study aimed to investigate the effect of drinking HRW on the severity of premenstrual symptoms and the q
Clinical Trial
MHID-14786562024Current Developments in Nutrition
Sonja Baltic, Nikola Todorovic, Marijana Ranisavljev, Dragana Zanini, David Nedeljkovic, Darinka Korovljev, et al.
Objectives: Molecular hydrogen (H2) and pyrroloquinoline quinone (PQQ) have been suggested to activate metabolic pathways associated with cognition. No human studies have assessed the efficacy of this nutritional combination in the clinical context of mild cognitive impairment (MCI). The primary objective of this randomized placebo-controlled trial was to evaluate the effects of a six-week suppleme
Clinical TrialAnimal StudyHighlighted
MHID-3437190PMID: 391167822024Biomedicine & Pharmacotherapy
Bing Xie, Yong Wang, Yun Lu, Mengmeng Wang, Rongji Hui, Hailei Yu, et al.
The gut-brain axis mediates the interaction pathway between microbiota and opioid addiction. In recent years, many studies have shown that molecular hydrogen has therapeutic and preventive effects on various diseases. This study aimed to investigate whether molecular hydrogen could serve as pharmacological intervention agent to reduce risks of reinstatement of opioid seeking and explore the mechan
Clinical TrialHighlighted
MHID-7865618PMID: 394347212024Frontiers in Physiology
Kaixiang Zhou, Chaoqun Yuan, Zhangyuting Shang, Wenhui Jiao, Yubo Wang
Background: Exercise-induced oxidative stress and inflammation can impair muscular function in humans. The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) highlight its potential to be as an effective nutritional supplement to support muscular function performance in healthy adults. However, the effects of H2 supplementation on muscular endurance performance in trained indivi
Clinical TrialHighlighted
MHID-1498378PMID: 392581912024Heliyon
Fenglin Wu, Jun Ma, Junli Xue, Xue Jiang, Jinyu Liu, Jiashuo Zhang, et al.
Background: Consumption of hydrogen-rich water (HRW) has been shown to have anti- inflammatory and metabolic-modulatory benefits.
Objective: A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia.
Methods: The Placebo grou
Clinical TrialAnimal Study
MHID-3281965PMID: 391245752024Journal of Clinical Medicine
Yoann Gaboreau, Aleksandra Milovanˇcev, Carole Rolland, Claire Eychenne, Jean-Pierre Alcaraz, Cordelia Ihl, et al.
Background. Due to its antioxidant, anti-inflammatory, anti-apoptosis, and anti-fatigue properties, molecular hydrogen (H2) is potentially a novel therapeutic nutrient for patients with coronavirus acute disease 2019 (COVID-19). We determined the efficacy and safety profile of hydrogen-rich water (HRW) to reduce the risk of COVID-19 progression.
Methods: We also conducted a phase 3, triple-blind,
Clinical TrialHighlighted
MHID-4782143PMID: 387947672024Nutrients
Yineng Tan, Yixun Xie, Gengxin Dong, Mingyue Yin, Zhangyuting Shang, Kaixiang Zhou, et al.
Background: Hydrogen (H2) may be a potential therapeutic agent for managing Long COVID symptoms due to its antioxidant and anti-inflammatory properties. However, more scientific literature is needed to describe the effects of H2 administration on treating symptoms. A study aimed to investigate the impact of hydrogen-rich water (HRW) administration on the fatigue and dyspnea of Long-COVID patients
Clinical TrialHighlighted
MHID-7984305PMID: 389082962024The Journal of Nutrition, Health and Aging
Sonja Baltic, David Nedeljkovic, Nikola Todorovic, Marijana Ranisavljev, Darinka Korovljev, Jelena Cvejic, et al.
Objectives: To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment.
Design: A parallel-group, randomized, placebo-controlled, double-blind experimental design, maintaining a 1:1 allocation ratio between the experimental group (
Clinical TrialHighlighted
MHID-3345925PMID: 391330682024Critical Care Medicine
Tomoyoshi Tamura, MD, Hiromichi Narumiya, MD, Koichiro Homma, MD, Masaru Suzuki, MD
OBJECTIVE: The Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID) II trial (jRCTs031180352) suggested that hydrogen inhalation may reduce post-cardiac arrest brain injury (PCABI). However, the combination of hypothermic target temperature management (TTM) and hydrogen inhalation on outcomes is unclear. The aim of this study was to i
Clinical TrialHighlighted
MHID-7726015PMID: 386811432024Frontiers in Physiology
Barbora Sládečková, Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Filip Neuls, et al.
Purpose: Molecular hydrogen has been shown to possess antioxidant, anti-inflammatory, ergogenic, and recovery-enhancing effects. This study aimed to assess the effect of molecular hydrogen administration on muscle performance, damage, and perception of soreness up to 24 h of recovery after two strenuous training sessions performed on the same day in elite fin swimmers.
Methods: Eight females (mean ±
Clinical TrialHighlighted
MHID-2861044PMID: 383977432024Antioxidants
Reiko Moribe, Marina Minami, Ryoji Hirota, Naw Awn J-P, Shigeru Kabayama, Masamitsu Eitoku, et al.
We studied the effect of three months’ use of electrolyzed hydrogen water (EHW, Elec-
trolyzed Hydrogen Water conditioner produced by Nihon Trim Co., Ltd.) on metabolic and pre-
metabolic syndrome groups. This research was carried out jointly by Susaki City; Nihon Trim Co.,
Ltd.; and Kochi University as part of a local revitalization project with health as a keyword. A ran-
domized, placebo-contro
