Observational StudyHighlighted
MHID-6285582PMID: 346451002021Journal of Integrative Neuroscience
Tyler W. LeBaron, Jason Kharman, Michael L. McCullough
Traumatic brain injuries (TBIs) are a leading cause of death and dis- ability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeosta- sis, mitochondrial dysfunction, and apoptosis. There is also a reduc- tion in cerebral blood flow, leading to hypoxia and reduced
Observational Study
MHID-82694502021Renal Replacement Therapy
Hidehisa Satta, Tamio Iwamoto, Yuki Kawai, Naoaki Koguchi, Kazuhiko Shibata, Nobuteru Kobayashi, et al.
Background: A novel hemodialysis (HD) system employing electrolyzed water containing molecular hydrogen (E-HD) has been developed to improve the bio-compatibility of HD. This study examined the impact of E-HD on changes in redox state during HD and HD-related fatigue.
Method: This single-arm, prospective observational study examined 63 patients on chronic HD (41 males; mean age, 72 ± 9 years; med
Observational StudyHighlighted
MHID-16201432021Renal Replacement Therapy
Yoshihiro Tsujimoto, Daisuke Kuratsune, Shigeru Kabayama, Mariko Miyazaki, Yasuyoshi Watanabe, Yoshiki Nishizawa, et al.
Background: Enhanced oxidative stress is involved with fatigue in hemodialysis (HD) patients. Molecular hydrogen (H2) could improve the redox status. Thus, the study examines whether HD solution rendered by electrolyzed water containing H2 (E-HD) could impact the fatigue and autonomic balance of patients.
Methods: This single-arm, prospective observational study examined 95 patients on chronic HD
Clinical TrialObservational StudyHighlighted
MHID-5538038PMID: 345130692021Sovremennye tehnologii v medicine
D.A. Danilova, Yu.D. Brichkin, A.P. Medvedev, V.V. Pichugin, S.A. Fedorov, E.V. Taranov, et al.
The aim of this work was to study the effect of molecular hydrogen on oxidative processes in cardiac surgery patients with acquired valve heart disease applied during surgery under cardiopulmonary bypass (CPB).
Materials and Methods. The study involved 20 patients (16 men and 4 women) with acquired heart valve disease who were operated on under CPB. Two groups of patients were formed. In group 1
Observational StudyHighlighted
MHID-7483719PMID: 329948212020Oncology Letters
Junji Akagi, Hideo Baba
As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial activators exhibit synergistic effects with nivolumab, the current study investigated whether hydrogen gas also affects the clinical outcomes of nivolumab. A total of 42 of 56 patients with lung cance
Observational StudyHighlighted
MHID-3602984PMID: 312492542019Medical Gas Research
Ryoko Asada, Yasukazu Saitoh, Nobuhiko Miwa
Hydrogen-dissolved water has been shown to improve diverse oxidation stress-related diseases, which drove us to examine effects of hydrogen-rich water on oxidation stress-related skin troubles and lipid-metabolism markers. The purpose of this study is whether the dissolved hydrogen in hydrogen-rich water was kept even after boiling, and whether hydrogen-bath utilization improves cosmetic effects s
Observational StudyHighlighted
MHID-9389875PMID: 325959372019F1000Research
Dejan Javorac, Valdemar Stajer, Sergej M Ostojic
Sport-related mild traumatic brain injury (TBI) is a serious
Background:
trauma that could impair brain function of an injured athlete. Treatment
solutions for mild TBI typically concentrate on complete rest, while
non-traditional therapeutic options remain largely ineffective. Molecular
hydrogen (H ) is an innovative neuroprotective agent that can easily reach
the brain, yet no data are available
Clinical TrialObservational StudyHighlighted
MHID-0370162PMID: 305427402019Oncology Reports
Junji Akagi, Hideo Baba
Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, the present study investigated whether it restores exhausted CD8+ T cells to impr
Observational Study
MHID-0991273PMID: 315528732019Medical Gas Research
Ji-Bing Chen, Xiao-Feng Kong, You-Yong Lv, Shu-Cun Qin, Xue-Jun Sun, Feng Mu, et al.
Advanced cancer treatment is a huge challenge and new ideas and strategies are required. Hydrogen exerts antioxidant and anti-inflammatory effects that may be exploited to control cancer, the occurrence and progression of which is closely related to peroxidation and inflammation. We conducted a prospective follow-up study of 82 patients with stage III and IV cancer treated with hydrogen inhalation
Observational Study
MHID-8360107PMID: 293215092018Scientific Reports
Masaaki Nakayama, Noritomo Itami, Hodaka Suzuki, Hiromi Hamada, Ryo Yamamoto, Kazumasa Tsunoda, et al.
Recent studies have revealed unique biological characteristics of molecular hydrogen (H2) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering an H2 (30–80 ppb)-enriched dialysis solution by water electrolysis, and conducted a non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocate
Observational StudyHighlighted
MHID-9655362PMID: 289029002017PLoS ONE
Masaaki Nakayama, Noritomo Itami, Hodaka Suzuki, Hiromi Hamada, Naoyuki Osaka, Ryo Yamamoto, et al.
Background and aim: It is supposed that enhanced oxidative stress and inflammation are involved with the poor clinical outcomes in patients on chronic dialysis treatment. Recent studies have shown that molecular hydrogen (H2) is biologically active as an anti-inflammatory agent. Thus, we developed a novel hemodialysis (E-HD) system which delivers H2 (30 to 80 ppb)-enriched dialysis solution, to co
Animal StudyIn VitroObservational StudyHighlighted
MHID-5280800PMID: 226080092012Medical Gas Research
Mikako Ito, Masaaki Hirayama, Kazuaki Yamai, Sae Goto, Masafumi Ito, Masatoshi Ichihara, et al.
Background: Lactulose is a synthetic disaccharide that can be catalyzed only by intestinal bacteria in humans and rodents, and a large amount of hydrogen is produced by bacterial catalysis of lactulose. We previously reported marked effects of ad libitum administration of hydrogen water on prevention of a rat model of Parkinson’s disease (PD).
Methods: End-alveolar breath hydrogen concentrations
Clinical TrialObservational Study
MHID-7186474PMID: 230310792012Medical Gas Research
Toru Ishibashi, Bunpei Sato, Mariko Rikitake, Tomoki Seo, Ryosuke Kurokawa, Yuichi Hara, et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in the pathogenesis of RA. Recently, molecular hydrogen (H2) was demonstrated to be a selective scavenger for the hydroxyl radical. Also, the method to prepare water containing extrem
Observational StudyHighlighted
MHID-0466448PMID: 229167062012Medical Gas Research
Hirohisa Ono, Yoji Nishijima, Naoto Adachi, Masaki Sakamoto, Yohei Kudo, Kumi Kaneko, et al.
Background: In animal experiments, use of molecular hydrogen ( H2) has been regarded as quite safe and effective, showing benefits in multiple pathological conditions such as ischemia-reperfusion injury of the brain, heart, kidney and transplanted tissues, traumatic and surgical injury of the brain and spinal cord, inflammation of intestine and lung, degenerative striatonigral tissue and also in m
In VitroObservational Study
MHID-9621518PMID: 220709002011Journal of Photochemistry and Photobiology B: Biology
Shinya Kato, Yasukazu Saitoh, Keizou Iwai, Nobuhiko Miwa
Hydrogen-rich electrolyzed warm water (HW) was prepared at 41ºC and exhibited dissolved hydrogen (DH) of 1.13 ppm and an oxidation-reduction potential (ORP) of -741 mV in contrast to below 0.01 ppm and +184 mV for regular warm water (RW).
Fibroblasts OUMS-36 and keratinocytes HaCaT were used to examine effects of HW against UVA-ray irradiation. Type-I collagen was synthesized 1.85- to 2.03-fold m
Clinical TrialObservational StudyHighlighted
MHID-8766045PMID: 202169472010Journal of Clinical Biochemistry and Nutrition
Atsunori Nakao, Yoshiya Toyoda, Prachi Sharma, Malkanthi Evans, Najla Guthrie
Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5–2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic
Clinical TrialObservational Study
MHID-1491336PMID: 199307632010British Journal of Nutrition
Min Li, Jian-Hua Piao, Yuan Tian, Wei-Dong Li, Ke-Ji Li, Xiao-Guang Yang
Consumption of resistant starch (RS)-enriched foods is associated with decrease in the postprandial glycaemic and insulinaemic responses, accompanied by the production of fermentation-related gases in the large bowel. The present study aimed to determine the postprandial glycaemic and insulinaemic responses to the GM RS-enriched rice and the fermentation-related production of H2 in young and healt
