Animal StudyHighlightedProfiling molecular changes induced by hydrogen treatment of lung allografts prior to procurementMHID-09896642012Biochemical and Biophysical Research CommunicationsYugo Tanaka, Norihisa Shigemura, Tomohiro Kawamura, Kentaro Noda, Kumiko Isse, Donna Beer Stolz, et al.Background—We previously demonstrated that donor treatment with inhaled hydrogen protects lung grafts from cold ischemia/reperfusion (I/R) injury during lung transplantation. To elucidate the mechanisms underlying hydrogen’s protective effects, we conducted a gene array analysis to identify changes in gene expression associated with hydrogen treatment. Methods—Donor rats were exposed to mechanica
Literature ReviewAnimal StudyHighlightedTherapeutic Effects of Hydrogen in Animal Models of Parkinson’s DiseaseMHID-2487138PMID: 257255222011Parkinson’s DiseaseKyota Fujita, Yusaku Nakabeppu, Mami NodaSince the first description of Parkinson’s disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symp- toms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using
