In VitroHighlighted
MHID-0634713PMID: 347707842021Molecules
In-Soo You, Subham Sharma, Ailyn Fadriquela, Johny Bajgai, Thuy Trinh Thi, Md. Habibur Rahman, et al.
Oxidative stress plays a crucial role in the development of airway diseases. Recently, hydrogen (H2) gas has been explored for its antioxidant properties. This study investigated the role of H2 gas in oxidative stress-induced alveolar and bronchial airway injury, where A549 and NCI-H292 cells were stimulated with hydrogen peroxide (H2O2) and lipopolysaccharide (LPS) in vitro. Results show that tim
Literature Review
MHID-9272690PMID: 330783742021Neuroscience Bulletin
Wei Chen, Han-Ting Zhang, Shu-Cun Qin
Molecular hydrogen (H2) is a physiologically inert gas. However, during the last 10 years, increasing evidence has revealed its biological functions under pathological conditions. More specifically, H2 has protec- tive effects against a variety of diseases, particularly nervous system disorders, which include ischemia/reperfu- sion injury, traumatic injury, subarachnoid hemorrhage, neuropathic pain
Literature Review
MHID-6029476PMID: 346464232021Oxidative Medicine and Cellular Longevity
Duried Alwazeer, Franky Fuh-Ching Liu, Xiao Yu Wu, Tyler W. LeBaron
COVID-19 is a widespread global pandemic with nearly 185 million confirmed cases and about four million deaths. It is caused by an infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which primarily affects the alveolar type II pneumocytes. The infection induces pathological responses including increased inflammation, oxidative stress, and apoptosis. This situation result
Literature Review
MHID-48068842021Hydrogen
Grace Russell, Alexander Nenov, Hesham Kisher, John T. Hancock
Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is gaining momentum, the idea of utilising this electrochemically neutral and non-polar diatomic compound for the benefit of health has yet to be widely acce
Literature Review
MHID-5326803PMID: 349874192021Frontiers in Physiology
Yan Tian, Yafang Zhang, Yu Wang, Yunxi Chen, Weiping Fan, Jianjun Zhou, et al.
Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2 inhalation has the therapeutic effects in many animal studies and clinical trials, and its application is recommended in the novel coronavirus pneumonia treatment guidelines in China recently. H2 has a relatively small molecular mass, which helps it quickly spread and penetrate cell membranes to exert a wide range
Clinical TrialObservational StudyHighlighted
MHID-5538038PMID: 345130692021Sovremennye tehnologii v medicine
D.A. Danilova, Yu.D. Brichkin, A.P. Medvedev, V.V. Pichugin, S.A. Fedorov, E.V. Taranov, et al.
The aim of this work was to study the effect of molecular hydrogen on oxidative processes in cardiac surgery patients with acquired valve heart disease applied during surgery under cardiopulmonary bypass (CPB).
Materials and Methods. The study involved 20 patients (16 men and 4 women) with acquired heart valve disease who were operated on under CPB. Two groups of patients were formed. In group 1
Clinical TrialHighlighted
MHID-1947207PMID: 346511332021Critical Care Explorations
Alexis R. Cole, BS, Francesca Sperotto, MD, James A. DiNardo, MD, Stephanie Carlisle, Michael J. Rivkin, MD, Lynn A. Sleeper, ScD, et al.
BACKGROUND: Ischemia-reperfusion injury is common in critically ill patients, and directed therapies are lacking. Inhaled hydrogen gas diminishes ischemia-reperfusion injury in models of shock, stroke, and cardiac arrest. The purpose of this study was to investigate the safety of inhaled hydrogen gas at doses required for a clinical efficacy study.
DESIGN: Prospective, single-arm study.
SETTING: T
Animal StudyHighlighted
MHID-1280112PMID: 344009012021International Journal of Medical Sciences
Hongxiao Yang, Shuang Liu, Huijun Du, Zi Hong, Yajing Lv, Chaoqun Nie, et al.
Purpose: Hydrogen (H2) is an antioxidant with anti-inflammatory and apoptosis functions.This study aimed to estimate the effects of H2 on acute myocardial infarction (AMI) in rats and its association with the inhibition of oxidative stress and cardiomyocyte pyroptosis. Methods: Sixty-four rats were randomly divided into three groups (Sham, AMI, and H2). The left anterior descending coronary artery
Human StudyLiterature ReviewAnimal Study
MHID-2665690PMID: 333492132021Current Pharmaceutical Design
Motoaki Sano, Tomoyoshi Tamura
Background: Mounting evidence indicates that hydrogen gas (H2) is a versatile therapeutic agent, even at very low, non-combustible concentrations. The Chinese National Health and Medical Commission recently recommended the use of inhaled H2 in addition to O2 therapy in the treatment of COVID-19-associated pneumonia, and its effects extend to anti-tumor, anti-inflammatory and antioxidant actions.
Literature ReviewHighlighted
MHID-9169500PMID: 327679252021Current Pharmaceutical Design
Shigeo Ohta
Molecular hydrogen (H2) was long regarded as non-functional in mammalian cells. We overturned the concept by demonstrating that H2 exhibits antioxidant effects and protects cells against oxidative stress. Subsequently, it has been revealed that H2 has multiple functions in addition to antioxidant effects, including anti-inflammatory, anti-allergic functions, and as cell death and autophagy regulat
Clinical Trial
MHID-2960170PMID: 333805812020Medical Gas Research
Yudai Shibayama, Shohei Dobashi, Takaaki Arisawa, Tamotsu Fukuoka, Katsuhiro Koyama
Molecular hydrogen has been suggested to have a cytoprotective effect on the whole body and to enhance exercise performances. However, the effect of hydrogen-rich gas mixture (HG) inhalation on physiological responses has been poorly investigated. We examined the impact of acute HG inhalation on subsequent oxidative stress, muscle damage, and exercise performances during the recovery period after
Animal Study
MHID-4743523PMID: 332440272020Scientific Reports
Kazuhisa Sugai, Tomoyoshi Tamura, Motoaki Sano, Shizuka Uemura, Masahiko Fujisawa, Yoshinori Katsumata, et al.
A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2
Literature ReviewMeta-Analysis
MHID-7985788PMID: 328266282020Current Opinion in Anesthesiology
Zhen Wang, Guolin Wang, Keliang Xie
Purpose of review: The current systematic review summarizes recent, basic clinical achievements regarding the neuroprotective effects of molecular hydrogen in distinct central nervous system conditions.
Recent findings: Perioperative neuroprotection remains a major topic of clinical anesthesia. Various gaseous molecules have previously been explored as a feasible therapeutic option in neurologica
Literature Review
MHID-9675573PMID: 320157862020Oxidative Medicine and Cellular Longevity
Takuji Kawamura, Kazuhiko Higashida, Isao Muraoka
Molecular hydrogen (H2) is a colorless, tasteless, odorless, and minimal molecule with high flammability. Although H2 has been thought to be an inert gas in living bodies for many years, an animal study reported that inhalation of H2 gas decreased oxidative stress and suppressed brain injury caused by ischemia and reperfusion injury due to its antioxidant action. Since then, the antioxidant action
Opinion Piece
MHID-94117542020Therapeutic Advances in Respiratory Disease
Sergej M Ostojic
Recent public reports by China’s National Health Commission and the Chinese Center for Disease Control and Prevention have recommended effective oxygen therapy measures as an element of general treatment in patients with novel coronavirus pneumonia (COVID-19).1,2 Both documents disclosed a rather exotic ratio of hydrogen and oxygen (66.6% H2 to 33.3% O2) as the composition of the gas mixture for i
Observational StudyHighlighted
MHID-7483719PMID: 329948212020Oncology Letters
Junji Akagi, Hideo Baba
As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial activators exhibit synergistic effects with nivolumab, the current study investigated whether hydrogen gas also affects the clinical outcomes of nivolumab. A total of 42 of 56 patients with lung cance
Animal StudyHighlighted
MHID-8428241PMID: 331161632020Scientific Reports
Zhi‑ming Xun, Qing‑hui Zhao, Yan Zhang, Fang‑di Ju, Jin He, Ting‑ting Yao, et al.
The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW i
Literature Review
MHID-3062702PMID: 327638202020Biomedicine & Pharmacotherapy
Qiongge Hu, Yunxiang Zhou, Shijie Wu, Wei Wu, Yongchuan Deng, Anwen Shao
In recent years, many studies have shown that hydrogen has therapeutic and preventive effects on various diseases. Its selective antioxidant properties were well noticed. Most of the ionizing radiation-induced damage is caused by hydroxyl radicals (.OH) from radiolysis of H2O . Since hydrogen can mitigate such damage through multiple mechanisms, it presents noteworthy potential as a novel radio-pro
Literature Review
MHID-3461972PMID: 309702152019Canadian Journal of Physiology and Pharmacology
Tyler W. LeBaron, Ismail Laher, Branislav Kura, Jan Slezak
H2 has been clinically demonstrated to provide antioxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic high-intensity exercise in elite athletes, or sporadic bouts of exercise (i.e. noxious exercise) in unt
Literature ReviewMechanisms Review
MHID-7292103PMID: 310571052019Current Pharmaceutical Design
Toru Ishibashi
Background: Molecular hydrogen (H2) is now recognized as a therapeutic gas for the treatment of numerous diseases including neurodegenerative diseases, metabolic disorders, and inflammatory diseases. Non- polar, neutral H2 is assumed to have health benefits facilitated by its passive diffusion across the human body immediately after administration and is considered a safe therapeutic inert gas tha
