Clinical TrialHighlighted
MHID-1498378PMID: 392581912024Heliyon
Fenglin Wu, Jun Ma, Junli Xue, Xue Jiang, Jinyu Liu, Jiashuo Zhang, et al.
Background: Consumption of hydrogen-rich water (HRW) has been shown to have anti- inflammatory and metabolic-modulatory benefits.
Objective: A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia.
Methods: The Placebo grou
Clinical TrialAnimal Study
MHID-3281965PMID: 391245752024Journal of Clinical Medicine
Yoann Gaboreau, Aleksandra Milovanˇcev, Carole Rolland, Claire Eychenne, Jean-Pierre Alcaraz, Cordelia Ihl, et al.
Background. Due to its antioxidant, anti-inflammatory, anti-apoptosis, and anti-fatigue properties, molecular hydrogen (H2) is potentially a novel therapeutic nutrient for patients with coronavirus acute disease 2019 (COVID-19). We determined the efficacy and safety profile of hydrogen-rich water (HRW) to reduce the risk of COVID-19 progression.
Methods: We also conducted a phase 3, triple-blind,
Clinical TrialHighlighted
MHID-4782143PMID: 387947672024Nutrients
Yineng Tan, Yixun Xie, Gengxin Dong, Mingyue Yin, Zhangyuting Shang, Kaixiang Zhou, et al.
Background: Hydrogen (H2) may be a potential therapeutic agent for managing Long COVID symptoms due to its antioxidant and anti-inflammatory properties. However, more scientific literature is needed to describe the effects of H2 administration on treating symptoms. A study aimed to investigate the impact of hydrogen-rich water (HRW) administration on the fatigue and dyspnea of Long-COVID patients
Clinical TrialHighlighted
MHID-7726015PMID: 386811432024Frontiers in Physiology
Barbora Sládečková, Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Filip Neuls, et al.
Purpose: Molecular hydrogen has been shown to possess antioxidant, anti-inflammatory, ergogenic, and recovery-enhancing effects. This study aimed to assess the effect of molecular hydrogen administration on muscle performance, damage, and perception of soreness up to 24 h of recovery after two strenuous training sessions performed on the same day in elite fin swimmers.
Methods: Eight females (mean ±
Chemical/Physicochemical StudyHighlighted
MHID-12000302024Water
Nikolay Vassilev, Ignat Ignatov, Teodora P. Popova, Fabio Huether, Alexander I. Ignatov, Mario T. Iliev, et al.
The present study investigated the 1H Nuclear Magnetic Resonance (NMR) spectra of hydrogen-rich water (HRW) produced using the EVObooster device. The analyzed HRW has pH = 7.1 ± 0.11, oxidation–reduction potential (ORP) of (−450 ± 11) mV, and a dissolved hydrogen concentration of 1.2 ppm. The control sample was tap water filtered by patented technology. A 600 NMR spectrometer was used to measure N
Clinical TrialHighlighted
MHID-2861044PMID: 383977432024Antioxidants
Reiko Moribe, Marina Minami, Ryoji Hirota, Naw Awn J-P, Shigeru Kabayama, Masamitsu Eitoku, et al.
We studied the effect of three months’ use of electrolyzed hydrogen water (EHW, Elec-
trolyzed Hydrogen Water conditioner produced by Nihon Trim Co., Ltd.) on metabolic and pre-
metabolic syndrome groups. This research was carried out jointly by Susaki City; Nihon Trim Co.,
Ltd.; and Kochi University as part of a local revitalization project with health as a keyword. A ran-
domized, placebo-contro
Animal StudyHighlighted
MHID-3103887PMID: 394463622024Translational Vision Science & Technology
Ruri Sugiyama, Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Takako Kikuchi, et al.
Purpose: To examine the effects of hydrogen water on retinal blood flow (RBF) dysregulation in diabetes, we evaluated changes in RBF in response to flicker stimulation and systemic hyperoxia in diabetic mice.
Methods: Twelve type 2 diabetic mice were divided into a group that received non-hydrogen water (n = 6, control group) and the other that received hydrogen-rich water (0.6–0.8 mM) (n = 6, HR
Meta-AnalysisHypothesisHighlighted
MHID-1049920PMID: 404064272024Gastroenterology and Hepatology From Bed to Bench
Ghazaleh Khalili-Tanha, Hamid Jamialahmadi, Mostafa Rezaei-Tavirani, Elham Nazari
Aim: This systematic review and meta-analysis aimed to assess the effect of hydrogen-rich water (HRW) on liver enzyme levels.
Background: Liver disease is a significant global health concern, greatly affecting mortality rates. Elevated levels of liver enzymes, such as ALT, AST, ALP, and GGT are early symptoms of liver disorders, and various approaches can help reduce them. Recent studies have sho
In VitroHighlighted
MHID-2493537PMID: 390620202024Biomedicines
Sing-Hua Tsou, Sheng-Chieh Lin, Wei-Jen Chen, Hui-Chih Hung, Chun-Cheng Liao, Edy Kornelius, et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by exces- sive fat accumulation in the liver. Intracellular oxidative stress induced by lipid accumulation leads to various hepatocellular injuries including fibrosis. However, no effective method for mitigating MASLD without substantial side effects currently exists. Molecular hydrogen (H2) has garnered attention du
Animal StudyHighlighted
MHID-9892485PMID: 388393612024Biological and Pharmaceutical Bulletin
Risako Morishita, Ayaka Onishi, Maresuke Oya, Hirotsugu Karashima, Misato Mori, Yuka Kawatani, et al.
Ultrafine bubbles (UFBs), which are bubbles with diameters of less than 1 µm, are widely recognized for their ability to exist stably in liquid as a result of the effects of Brownian motion. In this study, we focused on hydrogen, known for its antioxidant potential, and explored the function of H2-filled UFBs, which encapsulate hydrogen, to determine their potential use as oral carriers for the de
Clinical TrialHighlighted
MHID-5367404PMID: 202031352023Processes
Johny Bajgai, Mihyun Lee, Yeon-Gyu Jang, Kiwon Lee, Subham Sharma, Yun Ju Jeong, et al.
A well-known functional gastrointestinal disorder called functional dyspepsia (FD) is
defined by dyspeptic symptoms without any structural abnormalities. In alternative intervention,
electrolyzed alkaline-reduced water (EARW) consumption is regarded as a treatment modality for
gastrointestinal symptoms despite its mechanism not yet fully understood. The present clinical
study aimed to investigate t
Literature Review
MHID-61283312023SciBase Clinical and Medical Case Reports
Grace Russell, Alexander Nenov
Human reproductive health is an integral part of personal well-being that can markedly impact upon individuals, couples,
families and the wider society. It is estimated that infertility affects 13 to 15% of the world’s population and with parents often
deciding to delay planning for pregnancy until later in life, age-related concerns about the viability of female oocytes, in partic
ular, are at th
Clinical TrialHighlighted
MHID-64165942023Processes
Subham Sharma, Yundeok Kim, Johny Bajgai, Md. Habibur Rahman, Yun Ju Jeong, Seong Hoon Goh, et al.
Chronic constipation is a common symptom-based disorder that affects patient quality of life. Electrolyzed hydrogen-rich alkaline reduced water (EHARW) helps treat gastrointestinal disorders owing to its various bioactive properties. This single-arm, open-labelled study aimed to investigate the improvement of EHARW (pH 9.5; H2 ≈0.5 mg/L) in chronic constipation patients. Thirty patients with chron
Clinical TrialHighlighted
MHID-5537085PMID: 375607462023Archives of Medical Science
Darinka Korovljev, Jelena Ostojic, Nikola Todorovic, Sergej M Ostojic
Introduction: We evaluated whether 12-week intake of molecular hydrogen (H2) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1 kg/m2) affects brain levels of the glutamate-glutamine-GABA cycle, critical amino acid neurotransmitters in the mechanism of neuronal activation during appetite regulation.
Methods: A 1.5-T single-voxel proton magnetic resonance spectrosco
Clinical TrialHighlighted
MHID-6939973PMID: 373719752023Antioxidants
Bing Liang, Le Shi, Dongyue Du, Hua Li, Ning Yi, Yue Xi, et al.
Objective: Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, and has shown benefits in glucose and lipid metabolism in certain animal metabolic disorder models. However, the potential benefits of H2 treatment in individuals with impaired fasting glucose (IFG) has seldom been studied. This randomized controlled study (RCT) aims to investigate the effects of hy
Systematic ReviewHighlighted
MHID-32722772023Pharmaceuticals
Nikola Todorovic, Julen Fernández-Landa, Asier Santibañez, Branislav Kura, Valdemar Stajer, Darinka Korovljev, et al.
Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge,
Clinical TrialHighlighted
MHID-9342144PMID: 377341172023Nutrition
Darinka Korovljev Ph.D., Nikola Todorovic M.Sc., Marijana Ranisavljev M.Sc., Bogdan Andjelic M.Sc., Nebojsa Kladar M.D., Ph.D., Valdemar Stajer Ph.D., et al.
The intricate relationship between the gut microbiota, its metabolites, and human health has garnered significant attention in recent years because of its potential role in the development of many diseases [1]. Among the various metabolites produced by the microbiota, a group of organic acids, known as short-chain fatty acids (SCFAs), has emerged as key regulators of host energy metabolism. These
Systematic ReviewHighlighted
MHID-3427886PMID: 373542432023Asian Pacific Journal of Cancer Prevention
Muhammad Nooraiman Zufayri Mohd Noor, Adlin Sofea Alauddin, Yin How Wong, Chung Yeng Looi, Eng Hwa Wong, Priya Madhavan, et al.
Background: Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summaris
Animal StudyHighlighted
MHID-6941053PMID: 378959072023Pharmaceuticals
Seyedeh Elnaz Nazari, Alex Tarnava, Nima Khalili-Tanha, Mahdieh Darroudi, Ghazaleh Khalili-Tanha, Amir Avan, et al.
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial. This study aimed to investigate the therapeutic potential of hydrogen-rich water (HRW) on muscle atrophy in a unilateral hind limb immobilization model. Thirty-six male Balb/C mice were divided into control (without
Animal StudyHighlighted
MHID-70633602023The Indonesian Biomedical Journal
Lina Hadi, Albert Manggading Hutapea, Florenly
BACKGROUND: Orthodontic tooth movement (OTM) may increase the risk of treatment-related complications for some diabetes mellitus (DM) patients. Hydrogen-rich water (HRW) has been demonstrated in many studies to reduce oxidative stress and cell damage. This study aimed to examine the levels of interleukin (IL)-1β, blood glucose level, body weight, tooth displacement, and population of osteoclasts a
