Clinical TrialHighlighted
MHID-6786572PMID: 307136692018Medical Gas Research
Yoshinori Tanaka, Yasuhiro Saihara, Kyoko Izumotani, Hajime Nakamura
In Japan, alkaline electrolyzed water (AEW) apparatus have been approved as a medical device. And for the patients with gastrointestinal symptoms, drinking AEW has been found to be effective in relieving gastrointestinal symptoms. But some users of AEW apparatus do not have abdominal indefinite complaint. Little attention has been given to the benefit for the users which have no abdominal indefini
Literature ReviewHighlighted
MHID-7292601PMID: 287518022017Journal of Clinical Biochemistry and Nutrition
Kenji Dohi, Kazue Satoh, Kazuyuki Miyamoto, Shusuke Momma, Kenichiro Fukuda, Ryo Higuchi, et al.
Oxidative stress caused by reactive oxygen species is considered a major mediator of tissue and cell injuries in various neuronal conditions, including neurological emergencies and neurodegenerative diseases. Molecular hydrogen is well characterized as a scavenger of hydroxyl radicals and peroxynitrite. Recently, the neuroprotective effects of treatment with molecular hydrogen have been reported i
Animal StudyHighlighted
MHID-6379034PMID: 284624512017Neurochemical Research
Yusuke Yoshii, Taikai Inoue, Yuya Uemura, Yusaku Iwasaki, Toshihiko Yada, Yusaku Nakabeppu, et al.
Molecular hydrogen (H2), as a new medical gas, has protective effects in neurological disorders including Parkinson’s disease (PD). In our previous report, the neuroprotective effect of drinking water with saturated H2 (H2 water) in PD mice might be due to stomach–brain interaction via release of gastric hormone, ghrelin. In the present study, we assessed the effect of H2-induced ghrelin more prec
Animal StudyHighlighted
MHID-9957925PMID: 282930842017World Journal of Gastroenterology
Nai-Ying Shen, Jian-Bin Bi, Jing-Yao Zhang, Si-Min Zhang, Jing-Xian Gu, Kai Qu, et al.
AIM
To investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved.
METHODS
Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the mice received NS
Animal StudyIn VitroHighlighted
MHID-7490434PMID: 287851462017World Journal of Gastroenterology
Ching-Pin Lin, Wen-Chen Chuang, Fung-Jou Lu, Chih-Yen Chen
AIM To investigate the effects of hydrogen-rich water (HRW) treatment on prevention of ethanol (EtOH)-induced early fatty liver in mice.
METHODS In vitro reduction of hydrogen peroxide by HRW was determined with a chemiluminescence system. Female mice were randomly divided into five groups: control, EtOH, EtOH + silymarin, EtOH + HRW and EtOH + silymarin + HRW. Each group was fed a Lieber-DeCarli
Animal StudyIn VitroHighlighted
MHID-7372149PMID: 268455012016
Yukako Muramatsu, MD, Mikako Ito, PhD, Takahiro Oshima, Seiji Kojima, MD, PhD, Kinji Ohno, MD, PhD
Bronchopulmonary dysplasia (BPD) is characterized by developmental arrest of the alveolar tissue. Oxidative stress is causally associated with development of BPD. The effects of hydrogen have been reported in a wide range of disease models and human diseases especially caused by oxidative stress. We made a rat model of BPD by injecting lipopolysaccharide (LPS) into the amniotic fluid at E16.5. The
Literature ReviewOpinion Piece
MHID-2698536PMID: 280038792016F1000Research
Sergej M Ostojic
Molecular hydrogen (H ) has recently been recognized as a potential novel therapeutic agent in biomedicine. Initially proposed to be a possible treatment for certain types of neuromuscular disorders, cardio-metabolic diseases and cancer, H improved clinical end-points and surrogate markers in several clinical trials, mainly acting as an anti-inflammatory agent and powerful antioxidant. In this pap
Literature Review
MHID-0365812PMID: 282172942016Medical Gas Research
Lei Huang
Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydrox
Literature Review
MHID-6430381PMID: 276439332016Physiological Research
J. Slezák, B. Kura, K. Frimmel, M. Zálešák, T. Ravingerová, C. Viczenczová, et al.
Excessive production of oxygen free radicals has been regarded as a causative common denominator of many pathological processes in the animal kingdom. Hydroxyl and nitrosyl radicals represent the major cause of the destruction of biomolecules either by a direct reaction or by triggering a chain reaction of free radicals. Scavenging of free radicals may act preventively or therapeutically. A number
Animal StudyHighlighted
MHID-6432478PMID: 259258892015BMC Neuroscience
Satoru Takeuchi, Kimihiro Nagatani, Naoki Otani, Hiroshi Nawashiro, Takashi Sugawara, Kojiro Wada, et al.
Background: Enhanced oxidative stress occurs in spontaneously hypertensive stroke-prone rats (SHRSP), and is important in blood–brain barrier (BBB) disruption. Hydrogen can exert potent protective cellular effects via reduction in oxidative stress in various diseases. The present study investigated whether long-term hydrogen treatment can improve neurological function outcome in the SHRSP model, a
Clinical TrialHighlighted
MHID-1221967PMID: 267838402015Antioxidants
Tetsuji Azuma, Mayu Yamane, Daisuke Ekuni, Yuya Kawabata, Kota Kataoka, Kenta Kasuyama, et al.
Oxidative stress is involved in the pathogenesis of periodontitis. A reduction of oxidative stress by drinking hydrogen-rich water (HW) might be beneficial to periodontal health. In this pilot study, we compared the effects of non-surgical periodontal treatment with or without drinking HW on periodontitis. Thirteen patients (3 women, 10 men) with periodontitis were divided into two groups: The con
Animal StudyHighlighted
MHID-0865356PMID: 213757532015The Journal of Thoracic and Cardiovascular Surgery
Yasuaki Kishimoto, MD, Taichi Kato, MD, PhD, Mikako Ito, PhD, Yoshiteru Azuma, MD, Yoshie Fukasawa, MD, Kinji Ohno, MD, PhD, et al.
Objective: The pathogenesis of pulmonary arterial hypertension (PAH) involves reactive oxygen species and inflammation. Beneficial effects of molecular hydrogen, which exerts both anti-inflammatory and antioxidative effects, have been reported for various pathologic conditions. We therefore hypothesized that molecular hydrogen would improve monocrotaline (MCT)-induced PAH in rats.
Methods: Nineteen
OtherHighlighted
MHID-0431541PMID: 265045152015Medical Gas Research
Ryosuke Kurokawa, Tomoki Seo, Bunpei Sato, Shin-ichi Hirano, Fumitake Sato
Molecular hydrogen (H2) is clinically administered; however, in some hospitals, H2 is given to patients without consideration of its safe use. In the present study, we prepared convenient and safe devices for the drinking of super-saturated H2 water, for intravenous drip infusion of H2-rich saline, and for the inhalation of H2 gas. In order to provide useful information for researchers using these
Animal StudyHighlighted
MHID-1117942PMID: 251770312014Biological & Pharmaceutical Bulletin
Yang-Suk Yoon, Ma. Easter Joy Villarosa Sajo, Rosa Mistica Coles Ignacio, Soo-Ki Kim, Cheol-Su Kim, Kyu-Jae Lee
Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying al- lergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we in- vestigated the effect of drinking hydrogen water (HW) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical
Literature ReviewAnimal StudyIn VitroHighlighted
MHID-45285932014European Journal of Neurodegenerative Diseases
Mami Noda, M. Ito, I. Ohsawa, K. Ohno
A new medical gas, molecular hydrogen (H2), has been reported to be effective for a variety of disorders and clinical trials have shown promising results. Though the precise mechanism is still unknown, it is obvious that H2 has multiple effects. The first prominent effect of H2 was as antioxidant or reactive oxygen species (ROS)-scavenger, though it blocks only hydroxyl radicals (•OH), which are t
Clinical TrialHighlighted
MHID-29235562014Sports medicine / News in Molecular Hydrogen Biomedicine
Sergej M Ostojic, Boris Vukomanovic, Julio Calleja-Gonzalez, Jay R Hoffman
Background: Because hydrogen therapy has been found beneficial for the treatment of inflammation, ischemia-reperfusion injury, and oxidative stress in humans, it seems useful to evaluate the effects of exogenously administered hydrogen as an element in the immediate management of sports-related soft tissue injuries. The main aim of this pilot study was to examine the effects of 2-week administrati
Animal StudyHighlighted
MHID-9010413PMID: 240087712013Cellular Physiology and Biochemistry
Sanhu Zhao, Ke Mei, Liren Qian, Yanyong Yang, Wen Liu, Yijuan Huang, et al.
Background: Aplasitc anemia (AA) is a bone marrow failure syndrome characterized by an immune-mediated destruction of hematopoietic stem cells. Though clinical symptoms could be ameliorated by bone marrow transplantation and/or immunosuppressive therapy, frequent recurrence and especially evolution of clonal hematologic diseases remains problematic clinically. Cytokines such as interferon-γ (IFN-γ
Literature ReviewHighlighted
MHID-2487803PMID: 306788962013International Journal of Biological Sciences
Liren Qian, Jianliang Shen, Yunhai Chuai, Jianming Cai
It is well known that most of the ionizing radiation-induced damage is caused by hydroxyl radicals (·OH) follows radiolysis of H2O. Molecular hydrogen (H2) has antioxidant activities by selectively reducing ·OH and peroxynitrite(ONOO-). We firstly hypothesized and demonstrated the ra-dioprotective effect of H2 in vitro and in vivo, which was also repeated on different experimental animal models by
Animal StudyHighlighted
MHID-1568601PMID: 242536162013Scientific Reports
Akio Matsumoto, Megumi Yamafuji, Tomoko Tachibana, Yusaku Nakabeppu, Mami Noda, Haruaki Nakaya
The therapeutic potential of molecular hydrogen (H2) is emerging in a number of human diseases and in their animal models, including in particular Parkinson’s disease (PD). H2 supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H2 supplementation does not result in detectable changes
Literature Review
MHID-0878205PMID: 236800322013Medical Gas Research
Brandon J Dixon, Jiping Tang, John H Zhang
Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these i
