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Literature Review

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

MHID-1191317PMID: 406196052025Advanced Science

Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, et al.

The delivery of molecular hydrogen (H2) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apoptosis. These effects contribute to a balanced and functional immune system, highlighting the therapeutic promise of H2 in various inflammatory conditions. However, t

Literature Review

Molecular hydrogen: A potential radioprotective agent

MHID-3062702PMID: 327638202020Biomedicine & Pharmacotherapy

Qiongge Hu, Yunxiang Zhou, Shijie Wu, Wei Wu, Yongchuan Deng, Anwen Shao

In recent years, many studies have shown that hydrogen has therapeutic and preventive effects on various diseases. Its selective antioxidant properties were well noticed. Most of the ionizing radiation-induced damage is caused by hydroxyl radicals (.OH) from radiolysis of H2O . Since hydrogen can mitigate such damage through multiple mechanisms, it presents noteworthy potential as a novel radio-pro

Literature Review

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

MHID-0878205PMID: 236800322013Medical Gas Research

Brandon J Dixon, Jiping Tang, John H Zhang

Studies on molecular hydrogen have evolved tremendously from its humble beginnings and have continued to change throughout the years. Hydrogen is extremely unique since it has the capability to act at the cellular level. Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these i

Literature Review

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

MHID-8352354PMID: 216215882012Biochimica et Biophysica Acta

Shigeo Ohta

Background: Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effectiv

Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted

The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research

MHID-1756030PMID: 221460822011Medical Gas Research

Shigeo Ohta, Atsunori Nakao, Kinji Ohno

This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.