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Clinical TrialHighlighted

A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss

MHID-0526057PMID: 365073292022Frontiers in Neuroscience

Masahiro Okada, Hideo Ogawa, Taro Takagi, Eriko Nishihara, Tadashi Yoshida, Jun Hyodo, et al.

Background: Hydrogen (H2) has been reported to be effective in reducing hearing loss due to several causes in animal studies. However, no study has examined the effectiveness of H2 in treating hearing loss in humans. Thus, we investigated whether H2 is effective for the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). Materials and methods: We conducted a double-blind randomize

Literature ReviewHighlighted

Meeting report: Second Hydrogen Molecule Biomedical Symposium in Beijing, China

MHID-2847992PMID: 278264242016Medical Gas Research

Ou-yang Chen, Zhou-heng Ye, Chong Li

June 27, 2015, the Second Hydrogen Molecule Biomedical Symposium and the Second meeting of the Professional Committee of Molecular Hydrogen Biology and Medicine of China Association of Promoting International Communication of health care was grand opening in the Capital of China, Beijing, sponsored by China Association of Promoting International Communication of health care, undertaken by Professi

Literature ReviewHighlighted

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles

MHID-7479916PMID: 264839532015Medical Gas Research

Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno

Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. I

Human StudyLiterature ReviewAnimal StudyIn VitroHighlighted

The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research

MHID-1756030PMID: 221460822011Medical Gas Research

Shigeo Ohta, Atsunori Nakao, Kinji Ohno

This report summarizes a brief description/history of the Hydrogen Research Meetings as well as key presentations/oral abstracts delivered in the most recent symposium. Additionally, we introduced 38 diseases and physiological states for which hydrogen exhibits beneficial effects.

Animal StudyHighlighted

Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs

MHID-9017895PMID: 208883922010Neuroscience Letters

Ying Lin, Akinori Kashio, Takashi Sakamoto, Keigo Suzukawa, Akinobu Kakigi, Tatsuya Yamasoba

It has been shown that molecular hydrogen acts as a therapeutic and preventive antioxidant by selectively reducing the hydroxyl radical, the most cytotoxic of the reactive oxygen species. In the present study, we tested the hypothesis that acoustic damage in guinea pigs can be attenuated by the consumption of molecular hydrogen. Guinea pigs received normal water or hydrogen-rich water for 14 days