Animal StudyIn VitroHighlighted
MHID-5401653PMID: 413343742026Bioactive Materials
Yue Yuan, Zishuo Hou, Miaomiao Chen, Jingwei Yu, Minghao Zhou, Jiaxin Kang, et al.
The weaker soft tissue integration around implants compared to natural teeth poses a substantial challenge to the long-term success of implants. To enhance soft tissue integration, we develop an on-demand and long-lasting H2-releasing implant to achieve precise sequential regulation of the soft tissue integration through immunomodulation and pro-remodeling coupling. In the inflammatory phase, the
Animal StudyHighlighted
MHID-6979663PMID: 401889722025Toxicology and Applied Pharmacology
Mohammad Hossein Rigi, Seyyedeh Zahra Asghari, Elaheh Eshtad, Seyedeh Elnaz Nazari, Akram Aminian, Khatereh Kharazmi, et al.
Obesity can impair spermatogenesis by various mechanisms such as decreased sperm concentration and increased oxidative DNA damage. Hydrogen-rich water (HRW) possesses therapeutic antioxidant properties that may help offer protection to sperm. This study aimed to investigate the therapeutic potential of HRW on spermatogenesis dysfunction in rats with high-fat diet (HFD)-induced obesity. In this exp
Literature ReviewHighlighted
MHID-45792272025International Journal of Molecular Sciences
Dominika Zajac, Monika Jampolska, Piotr Wojciechowski
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-
inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current
therapeutic potential among others in inflammatory diseases, cancer, and sports medicine,
among others. The present review aims to provide a consistent summary of the findings
of the last twenty years on the use of molecular hydrogen in
Animal StudyIn VitroHighlighted
MHID-7283969PMID: 417999532025Materials Today Bio
Chunru Kong, Chao Si, Haofeng Liu, Yawen Wang, Jiakai Qiao, Xiaoduo Tang, et al.
The repair of infected bone defects (IBDs) presents a significant clinical challenge due to recurrent infections and
inflammation. Characterized by reactive oxygen species (ROS) bursts and mitochondrial dysfunction, IBDs
generates to a vicious oxidation-inflammation cycle that impairs bone remodeling. To address this, we developed
a double-network hydrogel scaffold composed of phenylboronic acid-m
Literature ReviewObservational StudyHighlighted
MHID-3682903PMID: 411676902025IN VIVO
YOU‐CHI REN, JENG‐WEI LU, YI‐JUNG HO, SHAN‐WEN LUI, TING‐YU HSIEH, KUANG‐YIH WANG, et al.
Background/Aim: Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting synovial joints, often causing
to joint destruction and systemic comorbidities. Cervical spine involvement, especially atlantoaxial subluxation (AAS),
can lead to spinal cord compression and neurological deficits. While disease‑modifying antirheumatic drugs (DMARDs)
are standard therapy, intolerance to agents like
Animal StudyIn VitroHighlighted
MHID-4061148PMID: 406876592025Translational Andrology and Urology
Qijie Chen, Shaoqing Yu, Yating Pan, Hong Tang, Yang Wang, Ninghan Feng, et al.
Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, leading to severe systemic complications and reduced quality of life. Current therapies often fail to comprehensively alleviate diabetic complications, highlighting the need for novel approaches. Animal studies and clinical trials have demonstrated the therapeutic potential of molecular hy
Animal StudyHighlighted
MHID-0413972PMID: 401127282025Food Chemistry
Hilal Kanmaz, Didem Şahingil, Duried Alwazeer, Menekşe Bulut, Mushap Kuru, Mustafa Makav, et al.
This study aimed to investigate the effects of hydrogen-rich water (HRW) consumption in goats on the chemical composition, antioxidant activity, total phenolic content, in vitro antidiabetic activity (α-amylase and α-glucosidase inhibitions), free fatty acid profile, and volatile compounds of colostrum and mature milk. Goats were fed ad libitum with either normal water (NW) or HRW for 20–22 days b
Animal StudyEx VivoHighlighted
MHID-4421003PMID: 398164752025Bioactive Materials
Yuanming An, Haozhi Zhang, Shi’an Zhang, Yuantao Zhang, Lizhen Zheng, Xin Chen, et al.
Biodegradable magnesium (Mg) implant generally provides temporary fracture fixation and facilitates bone regeneration. However, the exact effects of generated Mg ions (Mg2+), hydrogen gas (H2), and hydroxide ions (OH-) by Mg degradation on enhancing fracture healing are not fully understood. Here we investigate the in vivo degradation of Mg intramedullary nail (Mg-IMN), revealing the generation of
Animal StudyIn VitroEx VivoHighlighted
MHID-9370665PMID: 404119852025Biomaterials
Yuanming An, Lizhen Zheng, Shi’an Zhang, Haozhi Zhang, Yuantao Zhang, Hongwei Shao, et al.
Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing SAON model). Here we find that HRW treatment significantly reduces osteocyte apoptosis, improves deterio
Observational Study
MHID-3841687PMID: 379295122024Medical Gas Research
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue and malaise that persist for more than 6 months with neuropsychiatric symptoms, including slight fever, headache, weakness, impaired thinking, and depression. The onset and severity of these symptoms vary and reduce the quality of life as well as social, occupational, and personal activities of thos
Animal StudyHighlighted
MHID-3306838PMID: 394567942024International Journal of Molecular Sciences
Dmitrii Atiakshin, Andrey Kostin, Alexander Alekhnovich, Artem Volodkin, Michael Ignatyuk, Ilya Klabukov, et al.
Molecular hydrogen (H2) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced pulmonary hypertension (MPH), we had previously explored the impact of inhaled H2 on lung inflammation and blood pressure. In this study, we further focused the biological effects of H2 on mast cells (MCs) and the parameters of
Animal StudyHighlighted
MHID-3103887PMID: 394463622024Translational Vision Science & Technology
Ruri Sugiyama, Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Takako Kikuchi, et al.
Purpose: To examine the effects of hydrogen water on retinal blood flow (RBF) dysregulation in diabetes, we evaluated changes in RBF in response to flicker stimulation and systemic hyperoxia in diabetic mice.
Methods: Twelve type 2 diabetic mice were divided into a group that received non-hydrogen water (n = 6, control group) and the other that received hydrogen-rich water (0.6–0.8 mM) (n = 6, HR
Observational StudyHighlighted
MHID-0293642PMID: 375214102023Frontiers in Nutrition
Szu-Han Chiu, Frank L. Douglas, Jia-Ru Chung, Kuang-Yih Wang, Chao-Fang Chu, Hsia-Yun Chou, et al.
Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high visceral fat. Metabolic syndrome is linked to the build-up of plaque within the artery, which leads to disorders of the circulatory, nervous and immune systems. A variety of treatments targ
Clinical TrialHighlighted
MHID-6939973PMID: 373719752023Antioxidants
Bing Liang, Le Shi, Dongyue Du, Hua Li, Ning Yi, Yue Xi, et al.
Objective: Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, and has shown benefits in glucose and lipid metabolism in certain animal metabolic disorder models. However, the potential benefits of H2 treatment in individuals with impaired fasting glucose (IFG) has seldom been studied. This randomized controlled study (RCT) aims to investigate the effects of hy
Literature Review
MHID-1879460PMID: 378931902023Biomedicines
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
As diabetes rates surge globally, there is a corresponding rise in the number of patients suffering from diabetic kidney disease (DKD), a common complication of diabetes. DKD is a significant contributor to chronic kidney disease, often leading to end-stage renal failure. However, the effectiveness of current medical treatments for DKD leaves much to be desired. Molecular hydrogen (H2) is an antio
Systematic ReviewHighlighted
MHID-3427886PMID: 373542432023Asian Pacific Journal of Cancer Prevention
Muhammad Nooraiman Zufayri Mohd Noor, Adlin Sofea Alauddin, Yin How Wong, Chung Yeng Looi, Eng Hwa Wong, Priya Madhavan, et al.
Background: Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summaris
Literature ReviewMechanisms Review
MHID-5708535PMID: 373757652023Pharmaceuticals
Dmitri Atiakshin, Andrey Kostin, Artem Volodkin, Anna Nazarova, Viktoriya Shishkina, Dmitry Esaulenko, et al.
Knowledge of the biological effects of molecular hydrogen (H2), hydrogen gas, is con- stantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, viral hepatitis, mental and behavioral disorders). However, mechanisms underlying the biological effect
Literature Review
MHID-5798437PMID: 354938142022Frontiers in Neurology
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disorder that is characterized by fatigue that persists for more than 6 months, weakness, sleep disturbances, and cognitive dysfunction. There are multiple possible etiologies for ME/CFS, among which mitochondrial dysfunction plays a major role in abnormal energy metabolism. The potential of many substances for the treatment of ME/CF
Animal StudyHighlighted
MHID-1698660PMID: 354927052022Frontiers in Psychiatry
Noriyoshi Usui, Kazumasa Matsumoto-Miyai, Yoshihisa Koyama, Yuki Kobayashi, Yukiko Nakamura, Hikaru Kobayashi, et al.
Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we h
Animal StudyHighlighted
MHID-1506377PMID: 363585252022Antioxidants
Santiago Coral-Pérez, Ignacio Martínez-Martel, Maria Martínez-Serrat, Gerard Batallé, Xue Bai, Christie R. A. Leite-Panissi, et al.
Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H2) as a new therapy for neurological disorders has been demonstrated. Recent studies prove its analgesic properties in animals with neuropathic pain, but the possible antinociceptive, antidepressant, and/or anxiolytic actions of H2 during persistent inflammatory pain have not been investigated. Theref
