Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment

Abstract

Knowledge of the biological effects of molecular hydrogen (H2), hydrogen gas, is con- stantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, viral hepatitis, mental and behavioral disorders). However, mechanisms underlying the biological effects of H2 are still being actively debated. In this review, we focus on mast cells as a potential target for H2 at the specific tissue microenvironment level. H2 regulates the processing of pro-inflammatory components of the mast cell secretome and their entry into the extracellular matrix; this can significantly affect the capacity of the integrated-buffer metabolism and the structure of the immune landscape of the local tissue microenvironment. The analysis performed highlights several potential mechanisms for developing the biological effects of H2 and offers great opportunities for translating the obtained findings into clinical practice.

Study details

Article type

Review

Outcome

Positive

Findings

The review highlights mast cells as a promising target for molecular hydrogen (H2) in regulating local tissue microenvironments, particularly through modulation of pro-inflammatory mediators and secretome components. H2 may exert anti-inflammatory, anti-apoptotic, immunomodulatory, and tissue remodeling effects by influencing mast cell activity and ROS-mediated pathways, offering potential for clinical translation in managing acute and chronic inflammation.