Literature Review
MHID-1191317PMID: 406196052025Advanced Science
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, et al.
The delivery of molecular hydrogen (H2) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apoptosis. These effects contribute to a balanced and functional immune system, highlighting the therapeutic promise of H2 in various inflammatory conditions. However, t
Animal StudyHighlighted
MHID-4439338PMID: 401810802025Scientific Reports
Victor Pascal-Moussellard, Jean-Pierre Alcaraz, Stéphane Tanguy, Cordélia Salomez-Ihl, Philippe Cinquin, François Boucher, et al.
Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well as in clinical trials. As H2 is one of the major byproducts of inulin fermentation by bacterial species of the gut microbiota (GM), we hypothesized that H2 could mediate the antitumor effects of inulin. To provide evidence in favor of this hypothesis, we first determined the pattern of
Literature ReviewHighlighted
MHID-45792272025International Journal of Molecular Sciences
Dominika Zajac, Monika Jampolska, Piotr Wojciechowski
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-
inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current
therapeutic potential among others in inflammatory diseases, cancer, and sports medicine,
among others. The present review aims to provide a consistent summary of the findings
of the last twenty years on the use of molecular hydrogen in
Literature ReviewObservational StudyHighlighted
MHID-3682903PMID: 411676902025IN VIVO
YOU‐CHI REN, JENG‐WEI LU, YI‐JUNG HO, SHAN‐WEN LUI, TING‐YU HSIEH, KUANG‐YIH WANG, et al.
Background/Aim: Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting synovial joints, often causing
to joint destruction and systemic comorbidities. Cervical spine involvement, especially atlantoaxial subluxation (AAS),
can lead to spinal cord compression and neurological deficits. While disease‑modifying antirheumatic drugs (DMARDs)
are standard therapy, intolerance to agents like
Literature ReviewHighlighted
MHID-1339888PMID: 397659102024Antioxidants
Mikhail Yu. Artamonov, Felix A. Pyatakovich, Inessa A. Minenko
In regenerative medicine, mesenchymal stem cells (MSCs) have shown their importance and potential in tissue reconstruction and immune system modification. However, such cells’ potential is often diminished by factors such as oxidative stress, immune rejection, and inadequate engraftment. This review highlights the role of molecular hydrogen (H2) and cold atmospheric plasma (CAP) as adjunct therapi
Mechanisms ReviewHighlighted
MHID-3162417PMID: 386754292024Pharmaceuticals
Mikhail Yu. Artamonov, Tyler W. LeBaron, Felix A. Pyatakovich, Inessa A. Minenko
Stem cell therapy has emerged as a promising avenue for regenerative medicine, offering the potential to treat a wide range of debilitating diseases and injuries. Among the various types of stem cells, mesenchymal stem cells (MSCs) have garnered significant attention due to their unique properties and therapeutic potential. In recent years, researchers have been exploring novel approaches to enhan
Observational Study
MHID-5046710PMID: 394774202024In Vivo
Jing-Yuan Chen, Jeng-Wei Lu, Shao-Wei Feng, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, et al.
Background/Aim: Most nontraumatic subarachnoid hemorrhages (SAHs) are caused by ruptured saccular aneurysms, often resulting in a devastating clinical event characterized by high mortality and significant morbidity among survivors. Numerous studies have confirmed the neuroprotective effects of the molecular hydrogen due to its unique biological properties.
Case Report: We present the case of a 44
Literature ReviewHighlighted
MHID-5381032PMID: 369788842023Antioxidants
Mikhail Yu. Artamonov, Andrew K. Martusevich, Felix A. Pyatakovich, Inessa A. Minenko, Sergei V. Dlin, Tyler W. LeBaron
It is known that molecular hydrogen is a relatively stable, ubiquitous gas that is a minor component of the atmosphere. At the same time, in recent decades molecular hydrogen has been shown to have diverse biological effects. By the end of 2022, more than 2000 articles have been published in the field of hydrogen medicine, many of which are original studies. Despite the existence of several review
Literature ReviewMechanisms Review
MHID-5708535PMID: 373757652023Pharmaceuticals
Dmitri Atiakshin, Andrey Kostin, Artem Volodkin, Anna Nazarova, Viktoriya Shishkina, Dmitry Esaulenko, et al.
Knowledge of the biological effects of molecular hydrogen (H2), hydrogen gas, is con- stantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, viral hepatitis, mental and behavioral disorders). However, mechanisms underlying the biological effect
Animal StudyHighlighted
MHID-1698660PMID: 354927052022Frontiers in Psychiatry
Noriyoshi Usui, Kazumasa Matsumoto-Miyai, Yoshihisa Koyama, Yuki Kobayashi, Yukiko Nakamura, Hikaru Kobayashi, et al.
Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we h
Observational StudyHighlighted
MHID-7483719PMID: 329948212020Oncology Letters
Junji Akagi, Hideo Baba
As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial activators exhibit synergistic effects with nivolumab, the current study investigated whether hydrogen gas also affects the clinical outcomes of nivolumab. A total of 42 of 56 patients with lung cance
Clinical TrialObservational StudyHighlighted
MHID-0370162PMID: 305427402019Oncology Reports
Junji Akagi, Hideo Baba
Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, the present study investigated whether it restores exhausted CD8+ T cells to impr
In VitroHighlighted
MHID-1084413PMID: 264880872016Biochimica et Biophysica Acta - Molecular Cell Research
Jian-Dong Ren, Xiao-Bo Wu, Rui Jiang, Da-Peng Hao, Yi Liu
The NLRP3 inflammasome, an intracellular multi-protein complex controlling the maturation of cytokine interleukin-1β, plays an important role in lipopolysaccharide (LPS)-induced inflammatory cascades. Recently, the production of mitochondrial reactive oxygen species (mtROS) in macrophages stimulated with LPS has been suggested to act as a trigger during the process of NLRP3 inflammasome activation
Animal StudyHighlighted
MHID-29976812015Medical Science Monitor
Lijuan Yuan, Xiaoping Chen, Liren Qian, Jianliang Shen, Jianming Cai
Hydrogen, as a novel antioxidant, has been shown to selectively reduce the level of hydroxyl radicals and alleviate acute oxidative stress in many animal experiments. Hydrogen-rich saline provides a high concentration of hydrogen that can be easily and safely applied. Allogeneic hematopoietic stem-cell transplantation (HSCT) has been the most curative therapy for hematological malignancies. Howeve
Animal StudyHighlighted
MHID-1117942PMID: 251770312014Biological & Pharmaceutical Bulletin
Yang-Suk Yoon, Ma. Easter Joy Villarosa Sajo, Rosa Mistica Coles Ignacio, Soo-Ki Kim, Cheol-Su Kim, Kyu-Jae Lee
Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying al- lergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we in- vestigated the effect of drinking hydrogen water (HW) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical
Animal StudyHighlighted
MHID-5761446PMID: 246182602014Journal of Cellular and Molecular Medicine
Sanhu Zhao, Yanyong Yang, Wen Liu, Zhiqiang Xuan, Shouming Wu, Shunfei Yu, et al.
Recent studies showed that hydrogen can be used as an effective radioprotective agent through scavenging free radicals. This study was under-
taken to evaluate the radioprotective effects of hydrogen on immune system in mice. H2 was dissolved in physiological saline using an apparatus
produced by our department. Spleen index and histological analysis were used to evaluate the splenic structural da
Animal StudyHighlighted
MHID-9010413PMID: 240087712013Cellular Physiology and Biochemistry
Sanhu Zhao, Ke Mei, Liren Qian, Yanyong Yang, Wen Liu, Yijuan Huang, et al.
Background: Aplasitc anemia (AA) is a bone marrow failure syndrome characterized by an immune-mediated destruction of hematopoietic stem cells. Though clinical symptoms could be ameliorated by bone marrow transplantation and/or immunosuppressive therapy, frequent recurrence and especially evolution of clonal hematologic diseases remains problematic clinically. Cytokines such as interferon-γ (IFN-γ
Animal StudyIn VitroHighlighted
MHID-89507332012Medical Science Monitor
Yanyong Yang, Bailong Li, Cong Liu, Yunhai Chuai, Jixiao Lei, Fu Gao, et al.
Background: Radiation often causes depletion of immunocytes in tissues and blood, which results in immuno suppression. Molecular hydrogen (H2) has been shown in recent studies to have potential as a safe and effective radioprotective agent through scavenging free radicals. This study was designed to test the hypothesis that H2 could protect immunocytes from ionizing radiation (IR).
Material/Metho
Animal StudyHighlighted
MHID-1488636PMID: 192522952009Biological & Pharmaceutical Bulletin
Kyu Jae LEE, Dan JIN, Byung Soo CHANG, Yung Chien TENG, Dong Heui KIM
Electrolyzed reduced water (ERW) is widely used for drinking by people in Asia. The purpose of this study was to examine the immunological effect of ERW on the immunity of animals by supplying ERW to C57BL/6 mice infected with Echinostoma hortense metacercariae. In the non-infected groups, interleukin (IL)-4 (p0.001), IL-5, IL-10, IL-1b, tumor necrosis factor (TNF)-a and immunoglobulin (Ig) A exp
