Clinical TrialObservational StudyHighlighted
MHID-99610682021Journal of Education, Health and Sport
Yurii Rohovyi, Volf Tsitrin, Yula Bilooka, Ludmila Arkchipova, Vyacheslav Bilookiy
Aim. To find out a pathophysiological protective role of influence of molecular hydrogen on a functional condition of a proximal tubule of kidneys at an irritable bowel syndrome.
Materials and methods. 60 patients with irritable bowel syndrome were examined. Men - 18, women - 42 aged from 28 to 62 years. Of which: with irritable bowel syndrome with constipation were - 28 patients, irritable bowel
Clinical Trial
MHID-8601801PMID: 340791722021Biology of Sport
Rafael Timón, Guillermo Olcina, Adrian González-Custodio, Marta Camacho-Cardenosa, Alba Camacho-Cardenosa, Ismael Martínez Guardado
Hydrogen-rich water (HRW) is used as a supplement to improve performance and reduce fatigue in athletes. However, the potentially beneficial effects of HRW intake could be mediated by the training status of athletes. The purpose of the study was to analyse the ergogenic effect of intake of HRW for one week on aerobic and anaerobic performance, both in trained and untrained individuals. Thirty-seve
Animal StudyHighlighted
MHID-2919108PMID: 349481072021International Journal of Molecular Sciences
Eun-Sook Jeong, Johny Bajgai, In-Soo You, Md. Habibur Rahman, Ailyn Fadriquela, Subham Sharma, et al.
Oxidative stress (OS) is one of the causative factors in the pathogenesis of various neurode- generative diseases, including Alzheimer’s disease (AD) and cognitive dysfunction. In the present study, we investigated the effects of hydrogen (H2) gas inhalation in trimethyltin (TMT)-induced neurotoxicity and cognitive dysfunction in the C57BL/6 mice. First, mice were divided into the following groups
Animal Study
MHID-1210077PMID: 333568672021Canadian Journal of Physiology and Pharmacology
Jonatas E. Nogueira, Mateus R. Amorim, Ana P. Pinto, Alisson L. da Rocha, Adelino S. R. da Silva, Luiz G. S. Branco
Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H2) has emerged as a potent antioxidant, anti-inflammatory, and anti-apoptotic agent, but its act
In VitroHighlighted
MHID-0634713PMID: 347707842021Molecules
In-Soo You, Subham Sharma, Ailyn Fadriquela, Johny Bajgai, Thuy Trinh Thi, Md. Habibur Rahman, et al.
Oxidative stress plays a crucial role in the development of airway diseases. Recently, hydrogen (H2) gas has been explored for its antioxidant properties. This study investigated the role of H2 gas in oxidative stress-induced alveolar and bronchial airway injury, where A549 and NCI-H292 cells were stimulated with hydrogen peroxide (H2O2) and lipopolysaccharide (LPS) in vitro. Results show that tim
Animal StudyHighlighted
MHID-3829449PMID: 345024082021International Journal of Molecular Sciences
Mayo Miura, Kenji Imai, Hiroyuki Tsuda, Rika Miki, Sho Tano, Yumiko Ito, et al.
Oxidative stress plays a pathological role in pulmonary hypoplasia and pulmonary hypertension in congenital diaphragmatic hernia (CDH). This study investigated the effect of molecular hydrogen (H2), an antioxidant, on CDH pathology induced by nitrofen. Sprague-Dawley rats were divided into three groups: control, CDH, and CDH + hydrogen-rich water (HW). Pregnant dams of CDH + HW pups were orally ad
MHID-0478701PMID: 329814972021Current pharmaceutical design
Bajgai J, Lee KJ, Rahman MH, Fadriquela A, Kim CS.
In today's society, healthy skin and a beautiful appearance are considered the foundation of general well-being. The skin is the largest organ of the body and plays an important role in protecting it against various hazards such as environmental, physical, chemical, and biological hazards. These factors include mediators that lead to oxidation reactions that produce reactive oxygen/nitrogen specie
Opinion PieceHighlighted
MHID-62678002021Canadian Journal of Physiology and Pharmacology
Shigeo Ohta, Tyler W. LeBaron
The authors of the “Discussion” (Falster et al. 2021) have responded to our article entitled: “Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study”. Hydrogen (H2) medicine is being developed as an orthodox science. In this Reply, we would like to elaborate on the effects of H2-infused water and the scientific understand
Non-ExperimentalOther
MHID-5897036PMID: 345859572021Canadian Journal of Physiology and Pharmacology
Casper Falster, Svend Korfitzen, Martin Herold, Jan Lindebjerg, Morten Elsøe
Introduction
In 2019, Toshio Mikami et al. published the article “Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study” (Mikami et al. 2019).
The authors conclude that drinking hydrogen (H2) – infused water prior to exercise induces anti-fatigue effects and improves endurance when compared with placebo water.
While th
Literature ReviewHighlighted
MHID-8010762PMID: 348346332021Plants
John T. Hancock, Tyler W. LeBaron, Jennifer May, Adam Thomas, Grace Russell
Despite being trialed in other regions of the world, the use of molecular hydrogen (H2) for enhanced plant growth and the postharvest storage of crops has yet to be widely accepted in the UK. The evidence that the treatment of plants and plant products with H2 alleviates plant stress and slows crop senescence continues to grow. Many of these effects appear to be mediated by the alteration of the a
Observational StudyHighlighted
MHID-5864798PMID: 347652122021Clinical Case Reports
Ram B. Singh, Ghazi Halabi, Ghizal Fatima, Richa H. Rai, Alexander T. Tarnava, Tyler W. LeBaron
Administration of molecular hydrogen dissolved in water to patient with COVID-19-like symptoms may improve oxygen levels and exercise capacity.
Observational StudyHighlighted
MHID-6285582PMID: 346451002021Journal of Integrative Neuroscience
Tyler W. LeBaron, Jason Kharman, Michael L. McCullough
Traumatic brain injuries (TBIs) are a leading cause of death and dis- ability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeosta- sis, mitochondrial dysfunction, and apoptosis. There is also a reduc- tion in cerebral blood flow, leading to hypoxia and reduced
In VitroOtherHighlighted
MHID-32438852021Journal of Plant Growth Regulation
Xin Zhang, Fei Xie, Zhao Zhang, Yao Mawulikplimi Adzavon, Zehua Su, Qinghui Zhao, et al.
Molecular hydrogen has been shown to exert beneficial effects on plant growth and abiotic stress tolerance, however, the exact mechanism has not yet been fully elucidated. H2 is able to diffuse directly across the plasma membrane, which is the first barrier between H2 and cells. It is possible that H2 may exert its biological effects on plant cells by interacting with PM. Hydrogenases can catalyze
MHID-0918118PMID: 329549962021Current pharmaceutical design
Slezak J, Kura B, LeBaron TW, Singal PK, Buday J, Barancik M.
There are many situations of excessive production of reactive oxygen species (ROS) such as radiation, ischemia/reperfusion (I/R), and inflammation. ROS contribute to and arises from numerous cellular pathologies, diseases, and aging. ROS can cause direct deleterious effects by damaging proteins, lipids, and nucleic acids as well as exert detrimental effects on several cell signaling pathways. Howe
Clinical TrialAnimal StudyHighlighted
MHID-8498103PMID: 337420602021Scientific Reports
Miyuki Kubota, Motoko Kawashima, Sachiko Inoue, Toshihiro Imada, Shigeru Nakamura, Shunsuke Kubota, et al.
The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear fluids; however, to our knowledge, no agent that treats both pathologies simultaneously is available. Molecular hydrogen (H2) is known to be effective
Observational Study
MHID-82694502021Renal Replacement Therapy
Hidehisa Satta, Tamio Iwamoto, Yuki Kawai, Naoaki Koguchi, Kazuhiko Shibata, Nobuteru Kobayashi, et al.
Background: A novel hemodialysis (HD) system employing electrolyzed water containing molecular hydrogen (E-HD) has been developed to improve the bio-compatibility of HD. This study examined the impact of E-HD on changes in redox state during HD and HD-related fatigue.
Method: This single-arm, prospective observational study examined 63 patients on chronic HD (41 males; mean age, 72 ± 9 years; med
Literature ReviewHighlighted
MHID-9435089PMID: 330767982021Current Pharmaceutical Design
Mami Noda, Jiankang Liu, Jiangang Long
One of the beneficial effects of molecular hydrogen (H2, hydrogen gas) is neuroprotection and pre- vention of neurological disorders. It is important and useful if taking H2 every day can prevent or ameliorate the progression of neurodegenerative disorders, such as Parkinson’s disease or Alzheimer’s disease, both lacking specific therapeutic drugs. There are several mechanisms of how H2 protects n
Literature Review
MHID-9272690PMID: 330783742021Neuroscience Bulletin
Wei Chen, Han-Ting Zhang, Shu-Cun Qin
Molecular hydrogen (H2) is a physiologically inert gas. However, during the last 10 years, increasing evidence has revealed its biological functions under pathological conditions. More specifically, H2 has protec- tive effects against a variety of diseases, particularly nervous system disorders, which include ischemia/reperfu- sion injury, traumatic injury, subarachnoid hemorrhage, neuropathic pain
Literature Review
MHID-6029476PMID: 346464232021Oxidative Medicine and Cellular Longevity
Duried Alwazeer, Franky Fuh-Ching Liu, Xiao Yu Wu, Tyler W. LeBaron
COVID-19 is a widespread global pandemic with nearly 185 million confirmed cases and about four million deaths. It is caused by an infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which primarily affects the alveolar type II pneumocytes. The infection induces pathological responses including increased inflammation, oxidative stress, and apoptosis. This situation result
Literature Review
MHID-48068842021Hydrogen
Grace Russell, Alexander Nenov, Hesham Kisher, John T. Hancock
Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is gaining momentum, the idea of utilising this electrochemically neutral and non-polar diatomic compound for the benefit of health has yet to be widely acce
