Animal Study
MHID-7787642PMID: 361994282022Oxidative Medicine and Cellular Longevity
Long Ma, Wei Hao, Wen-Bo Feng, Lu-Cheng Cao, Li-Na Qin, Yao Wang, et al.
Infertility has got to be a broadly concerned social issue these days, in which the male factor cannot be overlooked. Numerous studies have shown that electromagnetic pulse (EMP) radiation may have seriously damaging effects on reproductive health, through nonthermal effects and oxidative stress. Molecular hydrogen, a selective hydroxyl radical scavenger, explains the protective effects against many
Animal StudyIn VitroHighlighted
MHID-2681523PMID: 355281642022BioMed Research International
Xiangyan Zhang, Geru Tao, Ya’nan Zhao, Sijie Xing, Jie Jiang, Boyan Liu, et al.
Objective. Molecular hydrogen (H2) has been considered a potential therapeutic target in many cancers. Therefore, we sought to assess the potential effect of H2 on colorectal cancer (CRC) in this study.
Methods. The effect of H2 on the proliferation and apoptosis of RKO, SW480, and HCT116 CRC cell lines was assayed by CCK-8, colony formation, and flow cytometry assays. The effect of H2 on tumor growt
Observational Study
MHID-22983482022Renal Replacement Therapy
Susumu Uemura, Yoshitaka Kegasa, Keigo Tada, Taichi Tsukahara, Shigeru Kabayama, Tae Yamamoto, et al.
Background: Reportedly, dialysis solutions containing molecular hydrogen (H2) might ameliorate patient-reported fatigue in hemodialysis (HD) patients. However, it is unknown whether its impact might differ with different H2 levels.
Method: This single-arm, prospective observational study examined 105 patients on chronic HD (62 males; mean age, 66 years; mean HD duration, 117 months). All patients
Literature Review
MHID-7890987PMID: 364990792022International Journal of Molecular Sciences
Tyler W. LeBaron, Randy Sharpe, Kinji Ohno
Numerous benefits have been attributed to alkaline-electrolyzed–reduced water (ERW). Sometimes these claims are associated with easily debunked concepts. The observed benefits have been conjectured to be due to the intrinsic properties of ERW (e.g., negative oxidation–reduction potential (ORP), alkaline pH, H2 gas), as well enigmatic characteristics (e.g., altered water structure, microclusters, fre
Literature ReviewHighlighted
MHID-2004094PMID: 364988382022International Journal of Molecular Sciences
Tyler W. LeBaron, Randy Sharpe, Kinji Ohno
Many studies demonstrate the safety of alkaline-electrolyzed–reduced water (ERW); however, several animal studies have reported significant tissue damage and hyperkalemia after drinking ERW. The mechanism responsible for these results remains unknown but may be due to electrode degradation associated with the production of higher pH, in which platinum nanoparticles and other metals that have harmf
Animal StudyHighlighted
MHID-0513892PMID: 351161142022World Journal of Gastrointestinal Oncology
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W. LeBaron
Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H2) has been re- cognized for its antioxidant and anti-inflammatory effects, with resear
Chemical/Physicochemical StudyHighlighted
MHID-3839513PMID: 361933472022Journal of Food Science and Technology
Duried Alwazeer, Nur Özkan
Strawberries are known for their high perishability and short shelf life. The effects of incorporating hydrogen gas into sealed packaging on the quality and shelf life of strawberries were evaluated. Fruits were packaged under reducing atmosphere [RAP1 (5% CO2, 4% H2, 91% N2) and RAP2 (10% CO2, 4% H2, 86% N2)], modified atmosphere [MAP1 (5% CO2, 95% N2) and MAP2 (10% CO2, 90% N2)], and control, fol
Literature ReviewHypothesisHighlighted
MHID-3205850PMID: 359678412022Frontiers in Cellular and Infection Microbiology
Sergej M Ostojic
The molecular footprints of COVID-19 occur everywhere, even reaching the family of biologically active gases and gasotransmitters. Besides nitric oxide and hydrogen sulfide, COVID-19 might also alter the homeostasis of dihydrogen (H2), another gaseous bioactive molecule produced endogenously by the human gut bacteria. Many studies have shown various alterations of the gut microbiota in patients wit
Animal StudyHighlighted
MHID-1698660PMID: 354927052022Frontiers in Psychiatry
Noriyoshi Usui, Kazumasa Matsumoto-Miyai, Yoshihisa Koyama, Yuki Kobayashi, Yukiko Nakamura, Hikaru Kobayashi, et al.
Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we h
Clinical TrialHighlighted
MHID-5245813PMID: 352061792022International Journal of Environmental Research and Public Health
Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, Petr Konečný, et al.
Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties. The aim of this study was to determine the effect of 14 days of H2 inhalation on the respiratory and physical fitness status of acute post-COVID-19 patients. This randomized, single-blin
Clinical TrialHighlighted
MHID-0754862PMID: 361246532022American Journal of Clinical Nutrition
Xiang Lv, Yuanfeng Lu, Guoyong Ding, Xiao Li, Xinxin Xu, Aihua Zhang, et al.
Background: Alcohol-induced hangover represents a significant, yet understudied, global hazard and a large socioeconomic burden. Objective: The aim of this study was to investigate the effects of hydrogen on relieving drinking and hangover symptoms in 20 healthy volunteers.
Methods: In this pilot, randomized, double-blinded, placebo- controlled, matched, crossover interventional trial, participan
Literature ReviewSystematic Review
MHID-8761287PMID: 357430352022International Journal of Molecular Sciences
Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar
Currently, there is a lot of public interest in naturally occurring substances with medicinal properties that are minimally toxic, readily available and have an impact on health. Over the past decade, molecular hydrogen has gained the attention of both preclinical and clinical researchers. The death of pyramidal neurons in especially the CA1 area of the hippocampus, increased permeability of the b
In SilicoHighlighted
MHID-4619667PMID: 360570012022Journal of Molecular Modeling
Song‑Ae Kim, Yu‑Chol Jong, Myong‑Su Kang, Chol‑Jun Yu
Recently, molecular hydrogen has been found to exhibit antioxidation activity through many clinical experiments, but the mechanism has not been fully understandable at atomic level. In this work, we perform systematic ab initio calculations of protoheme-hydrogen complexes to clarify the antioxidation mechanism of molecular hydrogen. We make molecular modeling of iron–protoporphyrin coordinated by
Clinical TrialHighlighted
MHID-0526057PMID: 365073292022Frontiers in Neuroscience
Masahiro Okada, Hideo Ogawa, Taro Takagi, Eriko Nishihara, Tadashi Yoshida, Jun Hyodo, et al.
Background: Hydrogen (H2) has been reported to be effective in reducing hearing loss due to several causes in animal studies. However, no study has examined the effectiveness of H2 in treating hearing loss in humans. Thus, we investigated whether H2 is effective for the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL).
Materials and methods: We conducted a double-blind randomize
Clinical TrialHighlighted
MHID-50217702022European Journal of Inflammation
Aleksandra Milovancev, Jovana Avakumovic, Patrik Drid, Nikola Todorovic, Valdemar Stajer, Sergej M Ostojic
Molecular hydrogen (H2) has been recently put forward as a possible adjunct therapeutics in COVID-19 due to its anti-inflammatory and pulmo-protective effects.1,2 An open-label randomized trial in 44 patients with laboratory-confirmed COVID-19 from seven hospitals in China demonstrated that 3-day hydrogen inhalation resulted in significantly more patients with improved disease severity and reduced dy
HypothesisOpinion PieceOtherHighlighted
MHID-0628712PMID: 356757612022Annals of Nutrition and Metabolism
Sergej M Ostojic
Molecular hydrogen (dihydrogen or hydrogen gas) is a small bioactive molecule involved in various metabolic pathways, from redox-sensitive reactions and cell signaling to bioenergetics and gut microbiota biology. Drinking hydrogen-rich water (HRW) has been suggested as a safe, novel, and promising nutritional strategy to attenuate metabolic disorders and burdensome and highly prevalent conditions
Clinical TrialObservational StudyHighlighted
MHID-6130347PMID: 357749172022Health Psychology Research
Ana Belén Fernández-Serrano, Francisco José Moya-Faz, Cesar Augusto Giner Alegría, Juan Carlos Fernández Rodríguez, Jose Francisco Soriano Guilabert, Martín del Toro Mellado
Research suggests that inflammation is an important mediator in the pathophysiology of anxiety disorders. In addition, women are more likely to develop an anxiety and depression disorder, in comorbidity with a wide spectrum of diseases related to the immune system. In recent years, hydrogen-rich water has emerged as a promising therapeutic strategy to prevent and intervene in stress-related disord
Hypothesis
MHID-81905412022Oxygen
John T. Hancock, Grace Russell, Tim J. Craig, Jennifer May, H. Ruth Morse, Jonathan S. Stamler
Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe), for example, is a well-known anesthetic. The direct targets of these gases, in most cases, remain elusive. Myoglobin and hemoglobin are known for their
Observational StudyHighlighted
MHID-8463226PMID: 354337312022Frontiers in Medicine
Xiaofeng Kong, Tianyu Lu, You-Yong Lu, Zhinan Yin, Kecheng Xu
Objective: To evaluate the clinical efficacy and safety of hydrogen inhalation in improving hearing loss in patients with long-term survival of nasopharyngeal carcinoma after radiotherapy.
Methods: The eustachian tube dysfunction score, pure tone air conduction threshold, bone conduction threshold, the score of tympanogram and otoscope were prospectively observed in patients with deafness after ra
Clinical TrialHighlighted
MHID-1269854PMID: 362782212022Frontiers in Pharmacology
Boyan Liu, Xue Jiang, Yunbo Xie, Xiubin Jia, Jiashuo Zhang, Yazhuo Xue, et al.
Objective: To explore the effect of a low-dose hydrogen–oxygen (H2-O2) mixture inhalation in midlife/older adults with hypertension.
Methods: This randomized, placebo-controlled trial included 60 participants with hypertension aged 50–70 years who were randomly divided into Air group (inhaled placebo air) or H2-O2 group [inhaled H2-O2 mixture (66% H2/33% O2)]. Participants in both groups were tre
