Clinical TrialIn VitroObservational StudyHighlighted
MHID-30414712023Processes
Richard J. Bloomer, Yufeng Zhang, Joshua Y. Shirazi, Chidimma Okegbe, Jacquelyn Pence, Keith Martin, et al.
Alpha Hope is a dietary supplement containing pyrroloquinoline quinone and elemental magnesium, which produces molecular hydrogen (H2 gas) when dissolved in water. We determined the impact of Alpha Hope on Nrf-2, peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), and citrate synthase (CS) activity in C2C12 myoblasts. Alpha Hope was titrated to three concentrations of pyrroloqui
Animal StudyChemical/Physicochemical StudyHighlighted
MHID-2226442PMID: 374635172023Canadian Journal of Physiology and Pharmacology
Barbora Kalocayova, Branislav Kura, Jana Vlkovicova, Denisa Snurikova, Norbert Vrbjar, Karel Frimmel, et al.
Cardiac surgery-associated acute kidney injury (CS-AKI) is a common postoperative complication, mostly due to increasing oxidative stress. Recently, molecular hydrogen (H2 gas), has also been applied to cardiac surgery due to its ability to reduce oxidative stress. We evaluated the potential effect of H2 application on the kidney in an in vivo model of simulated heart transplantation. Pigs underwe
Animal StudyIn VitroHighlighted
MHID-3225760PMID: 370564242023National Science Review
Qingqing Xu, Shengqiang Chen, Lingdong Jiang, Chao Xia, Lingting Zeng, Xiaoqing Cai, et al.
It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm. H2 is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability. In this work, we propose a concept of sonocatalytic hydrogen/hole-combined ‘in
Clinical TrialObservational StudyHighlighted
MHID-7657388PMID: 378737712023Diseases
Ram B. Singh, Alex Tarnava, Ghizal Fatima, Jan Fedacko, Viliam Mojto, Tyler W. LeBaron
Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and chronic respiratory failure. This study aims to determine if hydrogen-rich water (HRW) can enhance oxygen saturation among patients with chronic lung diseases. Methods: Ten patients with chronic lung diseases due to COPD (n = 7), bronchi
Clinical TrialHighlighted
MHID-71472332023Česká a Slovenská Oftalmologie
Mgr. Eliška Najmanová, Ph.D., H. Manethová, M. Botek, Doc. RNDr. František Pluháček, Ph.D.
Purposes: The primary aim of the study was to assess the response of intraocular pressure (IOP) to the acute ingestion of hydrogen-rich water (HRW) compared to hydrogen-free water (placebo) in healthy subjects. The effect of HRW intake on central corneal thickness (CCT) was also monitored.
Subjects and Methods: Twenty-four healthy volunteers (5 men, 19 women) aged between 20 and 33 were included i
In VitroPlant StudyHighlighted
MHID-7645260PMID: 379440262023Plant Physiology
Yueqiao Wang, Shanshan Jin, Ziyu Liu, Genmei Chen, Pengfei Cheng, Longna Li, et al.
A reliable and stable hydrogen gas (H2) supply will benefit agricultural laboratory and field trials. Here, we assessed ammonia borane (AB), an efficient hydrogen storage material used in the energy industry, and determined its effect on plant physiology and the corresponding mechanism. Through hydroponics and pot experiments, we discovered that AB increases tomato (Solanum lycopersicum) lateral r
Clinical TrialHighlighted
MHID-6311122PMID: 369693462023eClinicalMedicine
Tomoyoshi Tamura, Masaru Suzuki, Koichiro Homma, Motoaki Sano
Background Inhaled molecular hydrogen gas (H2) has been shown to improve outcomes in animal models of cardiac arrest (CA). H2 inhalation is safe and feasible in patients after CA. We investigated whether inhaled H2 would improve outcomes after out-of-hospital CA (OHCA).
Methods HYBRID II is a prospective, multicentre, randomised, double-blind, placebo-controlled trial performed at 15 hospitals in
Animal StudyHighlighted
MHID-70633602023The Indonesian Biomedical Journal
Lina Hadi, Albert Manggading Hutapea, Florenly
BACKGROUND: Orthodontic tooth movement (OTM) may increase the risk of treatment-related complications for some diabetes mellitus (DM) patients. Hydrogen-rich water (HRW) has been demonstrated in many studies to reduce oxidative stress and cell damage. This study aimed to examine the levels of interleukin (IL)-1β, blood glucose level, body weight, tooth displacement, and population of osteoclasts a
Literature Review
MHID-2770098PMID: 365713722023Medical Gas Research
Dinesh Ramanathan, Lei Huang, Taylor Wilson, Warren Boling
Reactive oxygen species and other free radicals cause oxidative stress which is the underlying pathogenesis of cellular injury in various neurological diseases. Molecular hydrogen therapy with its unique biological property of selectively scavenging pathological free radicals has demonstrated therapeutic potential in innumerable animal studies and some clinical trials. These studies have implicate
Clinical TrialObservational StudyHighlighted
MHID-0894811PMID: 399679162023Sovremennye tehnologii v medicine
V.V. Pichugin, A.V. Derugina, S.E. Domnin, A.S. Shirshin, S.A. Fedorov, S.N. Buranov, et al.
The aim is to study the effect of combined introduction of nitric oxide and hydrogen into the extracorporeal circuit of cardiopulmonary bypass (CPB) for antioxidant activity and organ damage during cardiac surgery.
Materials and Methods. The study included 91 patients who underwent heart surgery under CPB. The patients were randomized into 3 groups: group 1 comprised 30 patients (control); group
Literature Review
MHID-8327320PMID: 365673612023Molecular Neurobiology
Chongyun Wu, Peibin Zou, Shu Feng, Ling Zhu, Fanghui Li, Timon Cheng‑Yi Liu, et al.
Oxidative stress and neuroinflammation are the main physiopathological changes involved in the initiation and progression of various neurodegenerative disorders or brain injuries. Since the landmark finding reported in 2007 found that hydrogen reduced the levels of peroxynitrite anions and hydroxyl free radicals in ischemic stroke, molecular hydrogen’s antioxidative and anti-inflammatory effects have
Clinical TrialHighlighted
MHID-0848980PMID: 366757282022Journal of Personalized Medicine
Hua Lin, Jian Du, Zhigang Tian, Yonghao Yu, Yan Cui, Keliang Xie
Purpose: Postoperative delirium is a state of acute brain dysfunction characterized by fluctuating mental status that affects millions of patients each year. We used prophylactic inhalation of hydrogen gas in elderly patients undergoing elective surgery to compare their occurrence of postoperative delirium with that of controls.
Methods: A total of 184 patients aged ≥65 years were enrolled and ran
Clinical TrialObservational Study
MHID-5379845PMID: 355648082022International Journal of Environmental Research and Public Health
Gengxin Dong, Jiahui Fu, Dapeng Bao, Junhong Zhou
Background: Exercise that exceeds the body’s accustomed load can lead to oxidative stress and increased fatigue during intense training or competition, resulting in decreased athletic performance and an increased risk of injury, and the new medicinal H2 may be beneficial as an antioxidant. Therefore, we explored the effect of short-term supplementation of hydrogen-rich water (HRW) on the work perfo
Clinical Trial
MHID-7655607PMID: 365385542022PLOS ONE
Michal Valenta, Michal Botek, Jakub Krejčí, Andrew McKune, Barbora Sládečková, Filip Neuls, et al.
Purpose This study investigated the effects of acute, pre-exercise, hydrogen rich water (HRW) ingestion on running time to exhaustion at maximal aerobic speed in trained track and field runners.
Methods Twenty-four, male runners aged 17.5 ± 1.8 years, with body mass index = 21.0 ± 1.3 kgm-2, and maximal oxygen uptake = 55.0 ± 4.6 mlkg-1min-1 (mean ± standard deviation) participated in this ran
Literature Review
MHID-5798437PMID: 354938142022Frontiers in Neurology
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disorder that is characterized by fatigue that persists for more than 6 months, weakness, sleep disturbances, and cognitive dysfunction. There are multiple possible etiologies for ME/CFS, among which mitochondrial dysfunction plays a major role in abnormal energy metabolism. The potential of many substances for the treatment of ME/CF
Clinical TrialHighlighted
MHID-6109070PMID: 362356282022Nutrients
Ahad Abdulkarim D. Alharbi, Noriaki Iwamoto, Naoyuki Ebine, Satoshi Nakae, Tatsuya Hojo, Yoshiyuki Fukuoka
This research examined the effects of single-dose molecular hydrogen (H2) supplements on acid-base status and local muscle deoxygenation during rest, high-intensity intermittent training (HIIT) performance, and recovery. Ten healthy, trained subjects in a randomized, double-blind, crossover design received H2-rich calcium powder (HCP) (1500 mg, containing 2.544 µg of H2) or H2-depleted placebo (15
Clinical Trial
MHID-7556506PMID: 352768672022Nutrients
Michal Botek, Deepesh Khanna, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, et al.
Hydrogen-rich water (HRW) supplementation has been shown to have an antifatigue effect across different modes of exercise. However, its effect on repeated sprint performance is unknown. The aim of this study was to assess the effect of pre-exercise HRW consumption on repeated sprint performance, lactate, and perceptual responses using a repeated sprint protocol. This randomized, double blinded, pl
Animal Study
MHID-7818899PMID: 352644922022Experimental Animals
Kohei Kawakami, Hiroyuki Matsuo, Takaya Yamada, Ken-ichi Matsumoto, Daigoro Sasaki, Masato Nomura
Hydrogen-rich water (HW) has been suggested to possess antioxidant properties of value in treatments of lifestyle diseases and for prevention of latent pathologies. To date, the potential benefits of HW against the deleterious effects of excessive salt intake and hypertension have not been investigated. Here, we first examined the effects of HW or HW supplemented with 0.1% ascorbic acid (HWA) on s
In VitroHighlighted
MHID-35766222022Processes
Subham Sharma, Johny Bajgai, Jayson M. Antonio, Ailyn Fadriquela, Thuy Thi Trinh, Md. Habibur Rahman, et al.
Diabetes is coupled with hyperglycemia, a state in which elevated glucose levels trigger oxidative stress (OS) in various body functions. One of the organs most afflicted by diabetes is the kidney. Despite this, specific treatments to mitigate the harmful effects of hyperglycemia-induced OS in the kidney have not been extensively explored. This study evaluates the anti-hyperglycemic efficacy of magne
In VitroHighlighted
MHID-02613512022Processes
Subham Sharma, Kyu-Jae Lee, Johny Bajgai, Thuy Thi Trinh, Jayson M. Antonio, Md. Habibur Rahman, et al.
Diabetes, a chronic metabolic disorder, affects glucose consumption in the body and leads to severe kidney damage, known as diabetic nephropathy, where oxidative stress (OS) plays a vital role in disease pathogenesis. Electrolyzed weakly alkaline reduced water (EWARW) is known to have anti-oxidative functions in vitro due to its bioactive properties. However, there is an increasing need for adequa
