Animal StudyIn VitroHighlighted
MHID-7490434PMID: 287851462017World Journal of Gastroenterology
Ching-Pin Lin, Wen-Chen Chuang, Fung-Jou Lu, Chih-Yen Chen
AIM To investigate the effects of hydrogen-rich water (HRW) treatment on prevention of ethanol (EtOH)-induced early fatty liver in mice.
METHODS In vitro reduction of hydrogen peroxide by HRW was determined with a chemiluminescence system. Female mice were randomly divided into five groups: control, EtOH, EtOH + silymarin, EtOH + HRW and EtOH + silymarin + HRW. Each group was fed a Lieber-DeCarli
Literature Review
MHID-9316740PMID: 272811762017Current Neuropharmacology
Masumi Iketani, Ikuroh Ohsawa
Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The routes of H2 administration in animal model and human clinical studies are roughly classified into three types, inhalation of H2 gas, drinking H2-dissolved water, and injection of H2-dissolved saline. This
Animal Study
MHID-0745319PMID: 286562162017Molecular Medicine Reports
Jing Yang, Shujing Wu, Liqun Zhu, Jingjing Cai, Lu Fu
Cardiac fibrosis induced by sustained pressure overload contributes to heart failure. Oxidative stress serves an important role in cardiac remodeling and heart failure independent of etiological factors. The application of hydrogen as an antioxidant is a novel concept in disease treatment, however no studies as present have investigated the effects of hydrogen on cardiac fibrosis. In the present s
MHID-8826599PMID: 267744562016Biochemical pharmacology
Hou C, Wang Y, Zhu E, Yan C, Zhao L, Wang X, et al.
Diet-induced nonalcoholic fatty liver disease (NAFLD) is characterized by profound lipid accumulation and associated with an inflammatory response, oxidative stress and hepatic mitochondrial dysfunction. We previously demonstrated that some mitochondrial nutrients effectively ameliorated high fat diet (HFD)-induced hepatic steatosis and metabolic disorders. Molecular hydrogen in hydrogen-rich liqu
MHID-6003692PMID: 268496322016Shock (Augusta, Ga.)
Wang P, Jia L, Chen B, Zhang L, Liu J, Long J., et al.
Background: Non-shockable rhythms represent an increasing proportion of reported cases of out-of-hospital cardiac arrest but with an associated poor prognosis. In the present study, we investigated the effects of hydrogen inhalation on cardiac and neurological function after cardiopulmonary resuscitation and compared the therapeutic benefit with hypothermia in an asphyxial rat model of cardiac arr
Literature ReviewHighlighted
MHID-2847992PMID: 278264242016Medical Gas Research
Ou-yang Chen, Zhou-heng Ye, Chong Li
June 27, 2015, the Second Hydrogen Molecule Biomedical Symposium and the Second meeting of the Professional Committee of Molecular Hydrogen Biology and Medicine of China Association of Promoting International Communication of health care was grand opening in the Capital of China, Beijing, sponsored by China Association of Promoting International Communication of health care, undertaken by Professi
MHID-0640816PMID: 329674832016Oxidative Medicine and Cellular Longevity
Yijun Zheng, Duming Zhu
Since it was proposed in 2007, molecular hydrogen therapy has been widely concerned and researched. Many animal experiments were carried out in a variety of disease fields, such as cerebral infarction, ischemia reperfusion injury, Parkinson syndrome, type 2 diabetes mellitus, metabolic syndrome, chronic kidney disease, radiation injury, chronic hepatitis, rheumatoid arthritis, stress ulcer, acute
Animal StudyHighlighted
MHID-7644453PMID: 277741162016Oxidative Medicine and Cellular Longevity
Jiaming Guo, Deyun Zhao, Xiao Lei, Hainan Zhao, Yanyong Yang, Pei Zhang, et al.
Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H2 on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the
In VitroHighlighted
MHID-1084413PMID: 264880872016Biochimica et Biophysica Acta - Molecular Cell Research
Jian-Dong Ren, Xiao-Bo Wu, Rui Jiang, Da-Peng Hao, Yi Liu
The NLRP3 inflammasome, an intracellular multi-protein complex controlling the maturation of cytokine interleukin-1β, plays an important role in lipopolysaccharide (LPS)-induced inflammatory cascades. Recently, the production of mitochondrial reactive oxygen species (mtROS) in macrophages stimulated with LPS has been suggested to act as a trigger during the process of NLRP3 inflammasome activation
Animal StudyIn Vitro
MHID-6216976PMID: 267090142016Free radical biology & medicine
Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, et al.
Exposure to inflammation in utero is related to perinatal brain injury, which is itself associated with high rates of long-term morbidity and mortality in children. Novel therapeutic interventions during the perinatal period are required to prevent inflammation, but its pathogenesis is incompletely understood. Activated microglia are known to play a central role in brain injury by producing a vari
Animal StudyIn VitroHighlighted
MHID-8667127PMID: 277892932016Free Radical Biology and Medicine
Takafumi Ushida, Tomomi Kotani, Hiroyuki Tsuda, Kenji Imai, Tomoko Nakano, Shima Hirako, et al.
Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of preeclamps
Animal StudyIn VitroHighlighted
MHID-7372149PMID: 268455012016
Yukako Muramatsu, MD, Mikako Ito, PhD, Takahiro Oshima, Seiji Kojima, MD, PhD, Kinji Ohno, MD, PhD
Bronchopulmonary dysplasia (BPD) is characterized by developmental arrest of the alveolar tissue. Oxidative stress is causally associated with development of BPD. The effects of hydrogen have been reported in a wide range of disease models and human diseases especially caused by oxidative stress. We made a rat model of BPD by injecting lipopolysaccharide (LPS) into the amniotic fluid at E16.5. The
MHID-29829832016
Patrik Drid, Tatjana Trivić, Cristina Casals, Svetlana Trivić, Marko Stojanović, Sergej M Ostojic
Objectives: The purpose of this double-blind, randomized, placebo-controlled crossover study was to determine the effects of pre-exercise hydrogen-rich water intake on biomarkers of acid-base homeostasis and post-exercise recovery in female athletes.
Methods: Eight young female judo athletes (21.4 ± 2.2 years) were randomly assigned to receive either hydrogen-rich water or placebo water ∼ 30 minu
Literature ReviewOpinion Piece
MHID-2698536PMID: 280038792016F1000Research
Sergej M Ostojic
Molecular hydrogen (H ) has recently been recognized as a potential novel therapeutic agent in biomedicine. Initially proposed to be a possible treatment for certain types of neuromuscular disorders, cardio-metabolic diseases and cancer, H improved clinical end-points and surrogate markers in several clinical trials, mainly acting as an anti-inflammatory agent and powerful antioxidant. In this pap
Literature Review
MHID-0365812PMID: 282172942016Medical Gas Research
Lei Huang
Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydrox
Literature Review
MHID-6430381PMID: 276439332016Physiological Research
J. Slezák, B. Kura, K. Frimmel, M. Zálešák, T. Ravingerová, C. Viczenczová, et al.
Excessive production of oxygen free radicals has been regarded as a causative common denominator of many pathological processes in the animal kingdom. Hydroxyl and nitrosyl radicals represent the major cause of the destruction of biomolecules either by a direct reaction or by triggering a chain reaction of free radicals. Scavenging of free radicals may act preventively or therapeutically. A number
In VitroChemical/Physicochemical StudyHighlighted
MHID-6183029PMID: 267392572016Scientific Reports
Katsuya Iuchi, Akemi Imoto, Naomi Kamimura, Kiyomi Nishimaki, Harumi Ichimiya, Takashi Yokota, et al.
We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative stress. Subsequently, numerous studies have indicated the potential applications of H2 in therapeutic and preventive medicine. Moreover, H2 regulates various signal transduction pathways and the expression of many genes. However, the primary targets of H2 in the signal transduction pathways are unknown. Her
Animal StudyHighlighted
MHID-9482902PMID: 269362242016Molecular Medicine Reports
QU LIU, BAO‑SHAN LI, YU‑JIAO SONG, MING‑GEN HU, JIAN‑YUE LU, ANG GAO, et al.
Previous studies have demonstrated that hydrogen‑rich saline (HS) protects against bile duct ligation (BDL)‑induced liver injury by suppressing oxidative stress and inflammation. Mitochondria, which are targets of excessive reactive oxygen species and central mediators of apoptosis, have a pivotal role in hepatic injury during obstructive jaundice (OJ); however, the implications of HS in the hepat
Animal StudyIn VitroHighlighted
MHID-8944005PMID: 303740532016Scientific Reports
Yingni Lin, Bisei Ohkawara, Mikako Ito, Nobuaki Misawa, Kentaro Miyamoto, Yasuhiko Takegami, et al.
Molecular hydrogen (H2) is effective for many diseases. However, molecular bases of H2 have not been fully elucidated. Cumulative evidence indicates that H2 acts as a gaseous signal modulator. We found that H2 suppresses activated Wnt/β-catenin signaling by promoting phosphorylation and degradation οf β-catenin. Either complete inhibition of GSK3 or mutations at CK1- and GSK3-phosphorylation sites
Literature Review
MHID-7427440PMID: 255259532015International Journal of Sports Medicine
S. M. Ostojic
In the past 2 decades, molecular hydrogen emerged as a novel therapeutic agent, with anti-oxidant, anti-inflammatory and anti-apoptotic effects demonstrated in plethora of animal disease models and human studies. Beneficial effects of molecular hydrogen in clinical environment are observed especially in oxidative stress-mediated diseases, such as diabetes mellitus, brain stem infarction, rheumatoi
