Literature Review
MHID-87403452024Molecular Hydrogen in Health and Disease
Yunbo Xie, Guohua Song
It has been demonstrated that hydrogen molecules possess biological effects, and furthermore, they are colorless, non-toxic, and have a small molecular weight, enabling them to traverse the blood–brain barrier. This review synthesizes more than 100 publications on the use of hydrogen therapy in clinical ailments and categorizes the applications of hydrogen medicine into nine major systemic disease
Literature Review
MHID-9342689PMID: 371112992023Pharmaceuticals
Fei Xie, Yifei Song, Yang Yi, Xue Jiang, Shiwen Ma, Chen Ma, et al.
Oxidative stress and chronic inflammation have been implicated in the pathophysiology of metabolic diseases, including diabetes mellitus (DM), metabolic syndrome (MS), fatty liver (FL), atherosclerosis (AS), and obesity. Molecular hydrogen (H2) has long been considered a physiologically inert gas. In the last two decades, accumulating evidence from pre-clinical and clinical studies has indicated th
Observational Study
MHID-6877147PMID: 365168982023Brain Research Bulletin
Yong Wang, Mengmeng Wang, Bing Xie, Di Wen, Wenbo Li, Meiqi Zhou, et al.
Methamphetamine (METH) is a potent and highly addictive psychostimulant and one of the most widely used illicit drugs, the abuse of which has become a severe public health problem worldwide. A growing amount of evidence has indicated potential connections between gut microbiota and mental disorders induced by METH and associations with neural and metabolic pathways. The present study aimed to expl
Human StudyLiterature ReviewAnimal Study
MHID-3562676PMID: 372693852023Cellular and Molecular Life Sciences
Kwannapas Saengsin, Rekwan Sittiwangkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Cardiovascular disease is the leading cause of mortality worldwide. Excessive oxidative stress and inflammation play an important role in the development and progression of cardiovascular disease. Molecular hydrogen, a small colorless and odorless molecule, is considered harmless in daily life when its concentration is below 4% at room temperature. Owing to the small size of the hydrogen molecule,
Literature ReviewHighlighted
MHID-86080102023Oxygen
John T. Hancock, Tyler W. LeBaron
In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H2) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to sports injuries. Several methods of application have been developed, including breathing the gas, or making a hydrogen-rich solution that can be ingested,
Literature Review
MHID-61283312023SciBase Clinical and Medical Case Reports
Grace Russell, Alexander Nenov
Human reproductive health is an integral part of personal well-being that can markedly impact upon individuals, couples,
families and the wider society. It is estimated that infertility affects 13 to 15% of the world’s population and with parents often
deciding to delay planning for pregnancy until later in life, age-related concerns about the viability of female oocytes, in partic
ular, are at th
Systematic ReviewHighlighted
MHID-4621543PMID: 380675152023Molecules
Hennie Marie Johnsen, Marianne Hiorth, Jo Klaveness
With its antioxidant properties, hydrogen gas (H2) has been evaluated in vitro, in animal studies and in human studies for a broad range of therapeutic indications. A simple search of “hydrogen gas” in various medical databases resulted in more than 2000 publications related to hydrogen gas as a potential new drug substance. A parallel search in clinical trial registers also generated many hits, r
Observational StudyHighlighted
MHID-0293642PMID: 375214102023Frontiers in Nutrition
Szu-Han Chiu, Frank L. Douglas, Jia-Ru Chung, Kuang-Yih Wang, Chao-Fang Chu, Hsia-Yun Chou, et al.
Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high visceral fat. Metabolic syndrome is linked to the build-up of plaque within the artery, which leads to disorders of the circulatory, nervous and immune systems. A variety of treatments targ
Clinical TrialHighlighted
MHID-6939973PMID: 373719752023Antioxidants
Bing Liang, Le Shi, Dongyue Du, Hua Li, Ning Yi, Yue Xi, et al.
Objective: Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, and has shown benefits in glucose and lipid metabolism in certain animal metabolic disorder models. However, the potential benefits of H2 treatment in individuals with impaired fasting glucose (IFG) has seldom been studied. This randomized controlled study (RCT) aims to investigate the effects of hy
Literature Review
MHID-1879460PMID: 378931902023Biomedicines
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
As diabetes rates surge globally, there is a corresponding rise in the number of patients suffering from diabetic kidney disease (DKD), a common complication of diabetes. DKD is a significant contributor to chronic kidney disease, often leading to end-stage renal failure. However, the effectiveness of current medical treatments for DKD leaves much to be desired. Molecular hydrogen (H2) is an antio
Clinical TrialHighlighted
MHID-7707676PMID: 375698502023International Journal of Molecular Sciences
Zuzana Sumbalova, Jarmila Kucharská, Zuzana Rausová, Anna Gvozdjakova, Mária Szántová, Branislav Kura, et al.
Molecular hydrogen (H2) has been recognized as a novel medical gas with antioxidant and anti-inflammatory effects. Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increased fat accumulation in liver tissue caused by factors other than alcohol consumption. Platelet mitochondrial function is considered to reflect systemic mitochondrial health. We studied the ef- fect of adjuvant th
Systematic ReviewHighlighted
MHID-3427886PMID: 373542432023Asian Pacific Journal of Cancer Prevention
Muhammad Nooraiman Zufayri Mohd Noor, Adlin Sofea Alauddin, Yin How Wong, Chung Yeng Looi, Eng Hwa Wong, Priya Madhavan, et al.
Background: Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summaris
Meta-AnalysisHighlighted
MHID-3941772PMID: 368196972023Frontiers in nutrition
Kaixiang Zhou, Liu M, Wang Y, Liu H, Manor B, Bao D, et al.
Background: Fatigue is oftentimes induced by high-intensity exercise potentially via the exceeded amount of reactive oxygen species, leading to diminished functions (e.g., aerobic capacity) and increased risk of injuries. Studies indicate that molecular hydrogen (H2), with antioxidant and anti-inflammatory properties, may be a promising strategy to alleviate fatigue and improve aerobic capacity. H
Clinical TrialHighlighted
MHID-1277179PMID: 373719712023Antioxidants
Md. Habibur Rahman, Johny Bajgai, Subham Sharma, Eun-Sook Jeong, Seong Hoon Goh, Yeon-Gyu Jang, et al.
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer’s disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants, including those who dropped out (5%), were screened and enrolled. The selected
Literature ReviewHighlighted
MHID-6539221PMID: 372378542023Antioxidants
Md. Habibur Rahman, Eun-Sook Jeong, Hae Sun You, Cheol-Su Kim, Kyu-Jae Lee
Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. OS plays a crucial role in the dev
Clinical TrialHighlighted
MHID-8082099PMID: 362047842023Medical Gas Research
Anna Vaycheslavovna Deryugina, Darya Andreevna Danilova, Yurii Dmitrievich Brichkin, Evgenii Vladimirovich Taranov, Evgenii Ivanovich Nazarov, Vladimir Viktorovich Pichugin, et al.
Molecular hydrogen (H2) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical
Clinical Trial
MHID-8170738PMID: 381628312023Frontiers in Physiology
Nidhal Jebabli, Nejmeddine Ouerghi, Wissal Abassi, Fatma Hilal Yagin, Mariem Khlifi, Manar Boujabli, et al.
Molecular hydrogen (H2 gas) dissolved in water to produce Hydrogen-Rich Water. Hydrogen-Rich Water (HRW) is considered as ergogenic aid in different exercise modes. However, acute pre-exercise HRW ingestion effect is unclear regarding athlete performance. This study aimed at investigating acute effect of HRW ingestion on aerobic and anaerobic exercise performance. Twenty-two male amateur middle-di
Clinical TrialIn VitroObservational StudyHighlighted
MHID-30414712023Processes
Richard J. Bloomer, Yufeng Zhang, Joshua Y. Shirazi, Chidimma Okegbe, Jacquelyn Pence, Keith Martin, et al.
Alpha Hope is a dietary supplement containing pyrroloquinoline quinone and elemental magnesium, which produces molecular hydrogen (H2 gas) when dissolved in water. We determined the impact of Alpha Hope on Nrf-2, peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), and citrate synthase (CS) activity in C2C12 myoblasts. Alpha Hope was titrated to three concentrations of pyrroloqui
Clinical TrialObservational StudyHighlighted
MHID-7657388PMID: 378737712023Diseases
Ram B. Singh, Alex Tarnava, Ghizal Fatima, Jan Fedacko, Viliam Mojto, Tyler W. LeBaron
Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and chronic respiratory failure. This study aims to determine if hydrogen-rich water (HRW) can enhance oxygen saturation among patients with chronic lung diseases. Methods: Ten patients with chronic lung diseases due to COPD (n = 7), bronchi
Clinical TrialHighlighted
MHID-71472332023Česká a Slovenská Oftalmologie
Mgr. Eliška Najmanová, Ph.D., H. Manethová, M. Botek, Doc. RNDr. František Pluháček, Ph.D.
Purposes: The primary aim of the study was to assess the response of intraocular pressure (IOP) to the acute ingestion of hydrogen-rich water (HRW) compared to hydrogen-free water (placebo) in healthy subjects. The effect of HRW intake on central corneal thickness (CCT) was also monitored.
Subjects and Methods: Twenty-four healthy volunteers (5 men, 19 women) aged between 20 and 33 were included i
