Clinical TrialHighlighted
MHID-1498378PMID: 392581912024Heliyon
Fenglin Wu, Jun Ma, Junli Xue, Xue Jiang, Jinyu Liu, Jiashuo Zhang, et al.
Background: Consumption of hydrogen-rich water (HRW) has been shown to have anti- inflammatory and metabolic-modulatory benefits.
Objective: A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia.
Methods: The Placebo grou
Clinical TrialAnimal Study
MHID-3281965PMID: 391245752024Journal of Clinical Medicine
Yoann Gaboreau, Aleksandra Milovanˇcev, Carole Rolland, Claire Eychenne, Jean-Pierre Alcaraz, Cordelia Ihl, et al.
Background. Due to its antioxidant, anti-inflammatory, anti-apoptosis, and anti-fatigue properties, molecular hydrogen (H2) is potentially a novel therapeutic nutrient for patients with coronavirus acute disease 2019 (COVID-19). We determined the efficacy and safety profile of hydrogen-rich water (HRW) to reduce the risk of COVID-19 progression.
Methods: We also conducted a phase 3, triple-blind,
Clinical TrialHighlighted
MHID-4782143PMID: 387947672024Nutrients
Yineng Tan, Yixun Xie, Gengxin Dong, Mingyue Yin, Zhangyuting Shang, Kaixiang Zhou, et al.
Background: Hydrogen (H2) may be a potential therapeutic agent for managing Long COVID symptoms due to its antioxidant and anti-inflammatory properties. However, more scientific literature is needed to describe the effects of H2 administration on treating symptoms. A study aimed to investigate the impact of hydrogen-rich water (HRW) administration on the fatigue and dyspnea of Long-COVID patients
In VitroHighlighted
MHID-5509595PMID: 392466992024Regenerative Therapy
Koji Kimura, Yasuhiko Tabata
The objective of this study is to evaluate the effect of hydrogen gas on the biological functions of human adipose-derived stem cells (hADSC) in cryopreservation. hADSC were cryopreserved by a commercial cell preservation solution in the presence of hydrogen gas. After cryopreservation at 80 C, the viability, initial attachment morphology, and biological parameters of cells cryopreserved were eval
Clinical TrialObservational StudyHighlighted
MHID-1663378PMID: 383995332024Medicina
Shih-Feng Liu, Chin-Ling Li, Hui-Ching Lee, Hui-Chuan Chang, Jui-Fang Liu, Ho-Chang Kuo
Background and Objectives: Recent studies suggest that hydrogen gas possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. This study aimed to explore the therapeutic potential of hydrogen gas and assess its safety and tolerability in individuals with chronic obstructive pulmonary disease (COPD). Materials and Methods: Enrolled COPD patients received standard treatments along wit
Clinical TrialHighlighted
MHID-3345925PMID: 391330682024Critical Care Medicine
Tomoyoshi Tamura, MD, Hiromichi Narumiya, MD, Koichiro Homma, MD, Masaru Suzuki, MD
OBJECTIVE: The Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID) II trial (jRCTs031180352) suggested that hydrogen inhalation may reduce post-cardiac arrest brain injury (PCABI). However, the combination of hypothermic target temperature management (TTM) and hydrogen inhalation on outcomes is unclear. The aim of this study was to i
Clinical TrialHighlighted
MHID-7726015PMID: 386811432024Frontiers in Physiology
Barbora Sládečková, Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Filip Neuls, et al.
Purpose: Molecular hydrogen has been shown to possess antioxidant, anti-inflammatory, ergogenic, and recovery-enhancing effects. This study aimed to assess the effect of molecular hydrogen administration on muscle performance, damage, and perception of soreness up to 24 h of recovery after two strenuous training sessions performed on the same day in elite fin swimmers.
Methods: Eight females (mean ±
Chemical/Physicochemical StudyHighlighted
MHID-12000302024Water
Nikolay Vassilev, Ignat Ignatov, Teodora P. Popova, Fabio Huether, Alexander I. Ignatov, Mario T. Iliev, et al.
The present study investigated the 1H Nuclear Magnetic Resonance (NMR) spectra of hydrogen-rich water (HRW) produced using the EVObooster device. The analyzed HRW has pH = 7.1 ± 0.11, oxidation–reduction potential (ORP) of (−450 ± 11) mV, and a dissolved hydrogen concentration of 1.2 ppm. The control sample was tap water filtered by patented technology. A 600 NMR spectrometer was used to measure N
Clinical TrialHighlighted
MHID-2861044PMID: 383977432024Antioxidants
Reiko Moribe, Marina Minami, Ryoji Hirota, Naw Awn J-P, Shigeru Kabayama, Masamitsu Eitoku, et al.
We studied the effect of three months’ use of electrolyzed hydrogen water (EHW, Elec-
trolyzed Hydrogen Water conditioner produced by Nihon Trim Co., Ltd.) on metabolic and pre-
metabolic syndrome groups. This research was carried out jointly by Susaki City; Nihon Trim Co.,
Ltd.; and Kochi University as part of a local revitalization project with health as a keyword. A ran-
domized, placebo-contro
Animal StudyHighlighted
MHID-3103887PMID: 394463622024Translational Vision Science & Technology
Ruri Sugiyama, Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Takako Kikuchi, et al.
Purpose: To examine the effects of hydrogen water on retinal blood flow (RBF) dysregulation in diabetes, we evaluated changes in RBF in response to flicker stimulation and systemic hyperoxia in diabetic mice.
Methods: Twelve type 2 diabetic mice were divided into a group that received non-hydrogen water (n = 6, control group) and the other that received hydrogen-rich water (0.6–0.8 mM) (n = 6, HR
Meta-AnalysisHypothesisHighlighted
MHID-1049920PMID: 404064272024Gastroenterology and Hepatology From Bed to Bench
Ghazaleh Khalili-Tanha, Hamid Jamialahmadi, Mostafa Rezaei-Tavirani, Elham Nazari
Aim: This systematic review and meta-analysis aimed to assess the effect of hydrogen-rich water (HRW) on liver enzyme levels.
Background: Liver disease is a significant global health concern, greatly affecting mortality rates. Elevated levels of liver enzymes, such as ALT, AST, ALP, and GGT are early symptoms of liver disorders, and various approaches can help reduce them. Recent studies have sho
In VitroHighlighted
MHID-2493537PMID: 390620202024Biomedicines
Sing-Hua Tsou, Sheng-Chieh Lin, Wei-Jen Chen, Hui-Chih Hung, Chun-Cheng Liao, Edy Kornelius, et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by exces- sive fat accumulation in the liver. Intracellular oxidative stress induced by lipid accumulation leads to various hepatocellular injuries including fibrosis. However, no effective method for mitigating MASLD without substantial side effects currently exists. Molecular hydrogen (H2) has garnered attention du
Animal StudyHighlighted
MHID-9892485PMID: 388393612024Biological and Pharmaceutical Bulletin
Risako Morishita, Ayaka Onishi, Maresuke Oya, Hirotsugu Karashima, Misato Mori, Yuka Kawatani, et al.
Ultrafine bubbles (UFBs), which are bubbles with diameters of less than 1 µm, are widely recognized for their ability to exist stably in liquid as a result of the effects of Brownian motion. In this study, we focused on hydrogen, known for its antioxidant potential, and explored the function of H2-filled UFBs, which encapsulate hydrogen, to determine their potential use as oral carriers for the de
Animal StudyObservational StudyHighlighted
MHID-6966642PMID: 402326942024Medical Gas Research
Yusuke Ichikawa, Bunpei Sato, Shin-ichi Hirano, Yoshiyasu Takefuji, Fumitake Satoh
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, a neurodegenerative disorder characterized by sporadic and progressive degenerative loss of cell bodies of both the upper and lower motor neurons. Clinical manifestations of ALS are known to include lower motor neuron symptoms, upper motor neuron symptoms, bulboparesthesia symptoms, cognitive dysfunction, and negative signs. Dissociate
Literature ReviewOtherHighlighted
MHID-7822057PMID: 362047812023Medical Gas Research
Yusuke Ichikawa, Shin-ichi Hirano, Bunpei Sato, Haru Yamamoto, Yoshiyasu Takefuji, Fumitake Satoh
Despite the fact that we have reported on the dangers of the explosion of hydrogen gas inhalers, hydrogen gas inhalers with explosive hazards are, as a matter of fact, still being sold today. In this study, we investigated past reports of hydrogen gas inhaler explosion accidents to clarify the causes of these explosion incidents. As a result of this investigation, we found that the central cause w
Clinical TrialHighlighted
MHID-5367404PMID: 202031352023Processes
Johny Bajgai, Mihyun Lee, Yeon-Gyu Jang, Kiwon Lee, Subham Sharma, Yun Ju Jeong, et al.
A well-known functional gastrointestinal disorder called functional dyspepsia (FD) is
defined by dyspeptic symptoms without any structural abnormalities. In alternative intervention,
electrolyzed alkaline-reduced water (EARW) consumption is regarded as a treatment modality for
gastrointestinal symptoms despite its mechanism not yet fully understood. The present clinical
study aimed to investigate t
Animal StudyHighlighted
MHID-2924238PMID: 371112842023Pharmaceuticals
Murat Kayaba¸s, Levent ¸Sahin, Mustafa Makav, Duried Alwazeer, Levent Aras, Serdar Yi˘git, et al.
The anti-inflammatory and anti-apoptotic effects of molecular hydrogen, delivered as hydrogen-rich saline (HRS), on spinal cord injury was investigated. Four-month-old male Sprague Dawley rats (n = 24) were classified into four groups: (1) control—laminectomy only at T7-T10; (2) spinal injury—dura left intact, Tator and Rivlin clip compression model applied to the spinal cord for 1 min, no treatment
Literature Review
MHID-61283312023SciBase Clinical and Medical Case Reports
Grace Russell, Alexander Nenov
Human reproductive health is an integral part of personal well-being that can markedly impact upon individuals, couples,
families and the wider society. It is estimated that infertility affects 13 to 15% of the world’s population and with parents often
deciding to delay planning for pregnancy until later in life, age-related concerns about the viability of female oocytes, in partic
ular, are at th
Clinical TrialHighlighted
MHID-64165942023Processes
Subham Sharma, Yundeok Kim, Johny Bajgai, Md. Habibur Rahman, Yun Ju Jeong, Seong Hoon Goh, et al.
Chronic constipation is a common symptom-based disorder that affects patient quality of life. Electrolyzed hydrogen-rich alkaline reduced water (EHARW) helps treat gastrointestinal disorders owing to its various bioactive properties. This single-arm, open-labelled study aimed to investigate the improvement of EHARW (pH 9.5; H2 ≈0.5 mg/L) in chronic constipation patients. Thirty patients with chron
Systematic ReviewHighlighted
MHID-4621543PMID: 380675152023Molecules
Hennie Marie Johnsen, Marianne Hiorth, Jo Klaveness
With its antioxidant properties, hydrogen gas (H2) has been evaluated in vitro, in animal studies and in human studies for a broad range of therapeutic indications. A simple search of “hydrogen gas” in various medical databases resulted in more than 2000 publications related to hydrogen gas as a potential new drug substance. A parallel search in clinical trial registers also generated many hits, r
