Literature ReviewHighlightedDirect Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical ReactionsMHID-9169500PMID: 327679252021Current Pharmaceutical DesignShigeo OhtaMolecular hydrogen (H2) was long regarded as non-functional in mammalian cells. We overturned the concept by demonstrating that H2 exhibits antioxidant effects and protects cells against oxidative stress. Subsequently, it has been revealed that H2 has multiple functions in addition to antioxidant effects, including anti-inflammatory, anti-allergic functions, and as cell death and autophagy regulat
Systematic ReviewHighlightedEffect of hydrogen-rich water on periodontal disease, interleukin and blood glucose levels in diabetic: a systematic reviewMHID-30922442021Journal of Syiah Kuala Dentistry SocietyAlbert Manggading Hutapea, Lina HadiDiabetes Mellitus (DM) is a metabolic disorder characterized by high blood glucose levels associated with periodontal disease and increased levels of inflammatory biomarkers such as interleukin. Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated. This review aims to systematically analyze and review animal and human studies invest
In VitroProtective effects of dissolved molecular hydrogen against hydrogen peroxide‑, hydroperoxide‑, and glyoxal‑induced injuries to human skin keratinocytesMHID-0313161PMID: 340286462021Molecular and Cellular BiochemistryYasukazu Saitoh, Yuuki Yamaguchi, Yuhei OkadaMolecular hydrogen (H2) is recognized as a gaseous antioxidant, and it is expected to ameliorate various disorders related to oxidative stress and inflammation. However, there are still many unclear points regarding its effectiveness in the skin. Therefore, the purpose of this study was to examine the protective effect of H2 against ultraviolet (UV) irradiation-related stress injury in human epide
