Animal StudyHighlighted
MHID-8765977PMID: 390619242024Antioxidants
Ignacio Martínez-Martel, Xue Bai, Rebecca Kordikowski, Christie R. A. Leite-Panissi, Olga Pol
Chemotherapy-provoked peripheral neuropathy and its associated affective disorders are important adverse effects in cancer patients, and its treatment is not completely resolved. A recent study reveals a positive interaction between molecular hydrogen (H2) and a heme oxygenase (HO-1) enzyme inducer, cobalt protoporphyrin IX (CoPP), in the inhibition of neuropathic pain provoked by nerve injury. Ne
Clinical TrialHighlighted
MHID-6306651PMID: 394936772024OncoTargets and Therapy
Imjai Chitapanarux, Wimrak Onchan, Somvilai Chakrabandhu, Pooriwat Muangwong, Narongchai Autsavapromporn, Tapanut Ariyanon, et al.
Hydrogen (H2) gas inhalation might alleviate acute radiotherapy toxicities by scavenging free radicals produced by ionizing radiation and anti-inflammatory properties. This study aimed to investigate the feasibility and safety of H2 gas inhalation during concurrent chemoradiotherapy (CCRT) in patients with locally advanced head and neck cancer (LAHNC).
Patients and Methods: We designed a pilot pro
Animal StudyHighlighted
MHID-5098246PMID: 382641422024Sleep Advances
Scott M. Vincent, Melika Madani, Dante Dikeman, Kyle Golden, Naomi Crocker, Cameron Jackson, et al.
Study Objectives: Sleep loss contributes to various health issues and impairs neurological function. Molecular hydrogen has recently gained popularity as a nontoxic ergogenic and health promoter. The effect of molecular hydrogen on sleep and sleep-related neural systems remains unexplored. This study investigates the impact of hydrogen-rich water (HRW) on sleep behavior and neuronal acti- vation i
Clinical TrialHighlighted
MHID-7984305PMID: 389082962024The Journal of Nutrition, Health and Aging
Sonja Baltic, David Nedeljkovic, Nikola Todorovic, Marijana Ranisavljev, Darinka Korovljev, Jelena Cvejic, et al.
Objectives: To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment.
Design: A parallel-group, randomized, placebo-controlled, double-blind experimental design, maintaining a 1:1 allocation ratio between the experimental group (
Clinical TrialHighlighted
MHID-3345925PMID: 391330682024Critical Care Medicine
Tomoyoshi Tamura, MD, Hiromichi Narumiya, MD, Koichiro Homma, MD, Masaru Suzuki, MD
OBJECTIVE: The Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID) II trial (jRCTs031180352) suggested that hydrogen inhalation may reduce post-cardiac arrest brain injury (PCABI). However, the combination of hypothermic target temperature management (TTM) and hydrogen inhalation on outcomes is unclear. The aim of this study was to i
Animal StudyHighlighted
MHID-2726672PMID: 395318562024Tissue & cell
Cumaoglu MO, Makav M, Dag S, Uysal AY, Baser L, LeBaron TW, et al.
Gentamicin-induced nephrotoxicity primarily results from renal inflammatory cascades and increased oxidative stress. This study aims to examine the effects of hydrogen-rich water (HRW) on gentamicin-induced renal damage in rats. Thirty-two rats were equally divided into four groups, including control (no treatment), hydrogen, gentamicin, and gentamicin+hydrogen. At the end of one week, all animals
Animal StudyHighlighted
MHID-9069735PMID: 389256262024Animal Models and Experimental Medicine
Victor Pascal-Moussellard, Emilie Boucher, Stéphane Tanguy, Philippe Cinquin, Pierre-Alain Barraud, Chloé Davin, et al.
Background: Dihydrogen (H2) is produced endogenously by the intestinal microbiota through the fermentation of diet carbohydrates. Over the past few years, numerous studies have demonstrated the significant therapeutic potential of H2 in various pathophysiological contexts, making the characterization of its production in laboratory species of major preclinical importance.
Methods: This study prop
Clinical TrialHighlighted
MHID-7726015PMID: 386811432024Frontiers in Physiology
Barbora Sládečková, Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Filip Neuls, et al.
Purpose: Molecular hydrogen has been shown to possess antioxidant, anti-inflammatory, ergogenic, and recovery-enhancing effects. This study aimed to assess the effect of molecular hydrogen administration on muscle performance, damage, and perception of soreness up to 24 h of recovery after two strenuous training sessions performed on the same day in elite fin swimmers.
Methods: Eight females (mean ±
Clinical TrialHighlighted
MHID-2861044PMID: 383977432024Antioxidants
Reiko Moribe, Marina Minami, Ryoji Hirota, Naw Awn J-P, Shigeru Kabayama, Masamitsu Eitoku, et al.
We studied the effect of three months’ use of electrolyzed hydrogen water (EHW, Elec-
trolyzed Hydrogen Water conditioner produced by Nihon Trim Co., Ltd.) on metabolic and pre-
metabolic syndrome groups. This research was carried out jointly by Susaki City; Nihon Trim Co.,
Ltd.; and Kochi University as part of a local revitalization project with health as a keyword. A ran-
domized, placebo-contro
Animal StudyHighlighted
MHID-65602132024
Yuxi Wei
Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent upper airway collapse during sleep, leading to chronic intermittent hypoxia (CIH) that can cause oxidative stress and chronic inflammation that lead to cardiovascular disease (CVD). Although continuous positive airway pressure (CPAP) treatment is the gold standard for OSA treatment, it has little or no benefit in reduc
Animal StudyHighlighted
MHID-3103887PMID: 394463622024Translational Vision Science & Technology
Ruri Sugiyama, Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Takako Kikuchi, et al.
Purpose: To examine the effects of hydrogen water on retinal blood flow (RBF) dysregulation in diabetes, we evaluated changes in RBF in response to flicker stimulation and systemic hyperoxia in diabetic mice.
Methods: Twelve type 2 diabetic mice were divided into a group that received non-hydrogen water (n = 6, control group) and the other that received hydrogen-rich water (0.6–0.8 mM) (n = 6, HR
Animal StudyIn VitroEx Vivo
MHID-0828029PMID: 397658042024Antioxidants
Deng-Yu Kuo, Yu-Chi Wang, Pei-Han Chou, Chen-Wei Lai, Fu-I Tung, Tse-Ying Liu
Radiation dermatitis (RD) is a common side effect in patients receiving radiotherapy. Currently, clinical skincare approaches for acute RD vary widely among institutions and lack consensus. Hydrogen molecules, acting as radioprotective agents by selectively scavenging free radicals, have the potential to protect against RD. In this study, we demonstrate that hydrogen reduces double- strand breaks,
Animal StudyHighlighted
MHID-9892485PMID: 388393612024Biological and Pharmaceutical Bulletin
Risako Morishita, Ayaka Onishi, Maresuke Oya, Hirotsugu Karashima, Misato Mori, Yuka Kawatani, et al.
Ultrafine bubbles (UFBs), which are bubbles with diameters of less than 1 µm, are widely recognized for their ability to exist stably in liquid as a result of the effects of Brownian motion. In this study, we focused on hydrogen, known for its antioxidant potential, and explored the function of H2-filled UFBs, which encapsulate hydrogen, to determine their potential use as oral carriers for the de
Animal StudyObservational StudyHighlighted
MHID-6966642PMID: 402326942024Medical Gas Research
Yusuke Ichikawa, Bunpei Sato, Shin-ichi Hirano, Yoshiyasu Takefuji, Fumitake Satoh
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, a neurodegenerative disorder characterized by sporadic and progressive degenerative loss of cell bodies of both the upper and lower motor neurons. Clinical manifestations of ALS are known to include lower motor neuron symptoms, upper motor neuron symptoms, bulboparesthesia symptoms, cognitive dysfunction, and negative signs. Dissociate
Clinical TrialHighlighted
MHID-5367404PMID: 202031352023Processes
Johny Bajgai, Mihyun Lee, Yeon-Gyu Jang, Kiwon Lee, Subham Sharma, Yun Ju Jeong, et al.
A well-known functional gastrointestinal disorder called functional dyspepsia (FD) is
defined by dyspeptic symptoms without any structural abnormalities. In alternative intervention,
electrolyzed alkaline-reduced water (EARW) consumption is regarded as a treatment modality for
gastrointestinal symptoms despite its mechanism not yet fully understood. The present clinical
study aimed to investigate t
Observational Study
MHID-6877147PMID: 365168982023Brain Research Bulletin
Yong Wang, Mengmeng Wang, Bing Xie, Di Wen, Wenbo Li, Meiqi Zhou, et al.
Methamphetamine (METH) is a potent and highly addictive psychostimulant and one of the most widely used illicit drugs, the abuse of which has become a severe public health problem worldwide. A growing amount of evidence has indicated potential connections between gut microbiota and mental disorders induced by METH and associations with neural and metabolic pathways. The present study aimed to expl
Animal Study
MHID-6003573PMID: 364684152023CNS Neuroscience & Therapeutics
Qingqing Han, Yuanyuan Bai, Chunjing Zhou, Beibei Dong, Yingning Li, Ning Luo, et al.
Introduction: In our experiments, male wild-type mice were randomly divided into four groups: the sham, SAE, SAE + 2% hydrogen gas inhalation (H2), and SAE + hydrogen-rich water (HW) groups. The feces of the mice were collected for 16 S rDNA analysis 24 h after the models were established, and the serum and brain tissue of the mice were collected for nontargeted metabolomics analysis.
Aim: Destru
Human StudyLiterature ReviewAnimal Study
MHID-3562676PMID: 372693852023Cellular and Molecular Life Sciences
Kwannapas Saengsin, Rekwan Sittiwangkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Cardiovascular disease is the leading cause of mortality worldwide. Excessive oxidative stress and inflammation play an important role in the development and progression of cardiovascular disease. Molecular hydrogen, a small colorless and odorless molecule, is considered harmless in daily life when its concentration is below 4% at room temperature. Owing to the small size of the hydrogen molecule,
Animal StudyHighlighted
MHID-2924238PMID: 371112842023Pharmaceuticals
Murat Kayaba¸s, Levent ¸Sahin, Mustafa Makav, Duried Alwazeer, Levent Aras, Serdar Yi˘git, et al.
The anti-inflammatory and anti-apoptotic effects of molecular hydrogen, delivered as hydrogen-rich saline (HRS), on spinal cord injury was investigated. Four-month-old male Sprague Dawley rats (n = 24) were classified into four groups: (1) control—laminectomy only at T7-T10; (2) spinal injury—dura left intact, Tator and Rivlin clip compression model applied to the spinal cord for 1 min, no treatment
Animal Study
MHID-0385819PMID: 358952452023Journal of Neuroimmune Pharmacology
Wan‑Chao Yang, Ting‑ting Li, Qiang Wan, Xin Zhang, Li‑Ying Sun, Yu‑Rong Zhang, et al.
Diabetes is an independent risk factor for stroke and amplifies inflammation. Diabetic stroke is associated with a higher risk of death and worse neural function. The identification of effective anti-inflammatory molecules with translational advantages is particularly important to promote perioperative neurorestorative effects. Applying molecular hydrogen, we measured blood glucose levels before a
