Animal StudyHighlighted
MHID-8428241PMID: 331161632020Scientific Reports
Zhi‑ming Xun, Qing‑hui Zhao, Yan Zhang, Fang‑di Ju, Jin He, Ting‑ting Yao, et al.
The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW i
Clinical TrialHighlighted
MHID-0587967PMID: 319380042019Biology of Sport
Dejan Javorac, Valdemar Stajer, Laszlo Ratgeber, Jozsef Betlehem, Sergej Ostojic
In this randomized, double-blind, placebo-controlled, crossover pilot trial, we evaluated the effects of 7-day H2 inhalation on exercise performance outcomes and serum hormonal and inflammation profiles in a cohort of young men and women. All participants (age 22.9 ± 1.5 years; body mass index 23.4 ± 2.5 kg m-2; 10 women and 10 men) were allocated to receive either gaseous hydrogen (4%) or placebo
Animal StudyHighlighted
MHID-7662943PMID: 308305292019Molecular and Cellular Biochemistry
Branislav Kura, Barbora Kalocayova, Tyler W. LeBaron, Karel Frimmel, Jozef Buday, Juraj Surovy, et al.
microRNAs (miRNAs) constitute a large class of post-transcriptional regulators of gene expression. It has been estimated that miRNAs regulate up to 30% of the protein-coding genes in humans. They are implicated in many physiological and pathological processes, including those involved in radiation-induced heart damage. Biomedical studies indicate that molecular hydrogen has potential as a radiopro
Animal StudyIn SilicoHighlighted
MHID-9900832PMID: 294242532018
Hiroshi Nishiwaki, Mikako Ito, Shuto Negishi, Sayaka Sobue, Masatoshi Ichihara, Kinji Ohno
Background: Molecular hydrogen exerts its effect on multiple pathologies, including oxidative stress, inflammation, and apoptosis. However, its molecular mechanisms have not been fully elucidated. In order to explore the effects of molecular hydrogen, we meta-analyzed gene expression profiles modulated by molecular hydrogen.
Methods: We performed microarray analysis of the mouse liver with or wit
Animal StudyHighlighted
MHID-7672684PMID: 301277282018Frontiers in Behavioral Neuroscience
Qingjun Guo, Xi Yin, Meng Qiao, Yujiao Jia, Dandan Chen, Juan Shao, et al.
Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) administratio
In VitroHighlighted
MHID-1525156PMID: 299011392018Molecular Medicine Reports
YU JIANG, GANG LIU, LI ZHANG, SHENG CHENG, CHUN LUO, YANG LIAO, et al.
The aim of the present study was to investigate the effects of combination therapy of LY294002, a specific inhibitor of phosphatidylinositol 3‑kinase (PI3K), with hydrogen‑rich saline on the proliferation and apoptosis of the non‑small cell lung cancer (NSCLC) A549 cell line and the mechanisms underpinning this. Excessive production of reactive oxygen species (ROS) may induce DNA mutations, DNA d
In VitroHighlighted
MHID-1014265PMID: 286201982017Scientific Reports
Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Jui-Lin Liang, Jian-He Lu, Chia-Jung Yen, et al.
Based on the oxidative stress theory, aging derives from the accumulation of oxidized proteins induced by reactive oxygen species (ROS) in the cytoplasm. Hydrogen peroxide (H2O2) elicits ROS that induces skin aging through oxidation of proteins, forming disulfide bridges with cysteine or methionine sulfhydryl groups. Decreased Ca2+ signaling is observed in aged cells, probably secondary to the for
Clinical TrialHighlighted
MHID-7349011PMID: 286696542017Journal of Stroke and Cerebrovascular Diseases
Hirohisa Ono, MD, Yoji Nishijima, MD, Shigeo Ohta, PhD, Masaki Sakamoto, MD, Kazunori Kinone, MD, Tohru Horikosi, MD, et al.
Background: Molecular hydrogen (H2) acts as a therapeutic antioxidant. Inhalation of H2 gas (1-4%) was effective for the improvement of cerebral infarction in multiple animal experiments. Thus, for actual applications, a randomized con- trolled clinical study is desired to evaluate the effects of inhalation of H2 gas. Here, we evaluate the H2 treatment on acute cerebral infarction.
Methods: Throu
Animal StudyIn VitroHighlighted
MHID-9607497PMID: 290409782017Cellular Physiology and Biochemistry
Keyan Chen, Nan Wang, Yugang Diao, Wanwei Dong, YingJie Sun, Lidan Liu, et al.
Background/Aims: Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, and inhibit inflammation. This study investigated effects of HRS on brain injury induced by CPB and regulatory mechanisms of the PI3K/Akt/GSK3β signaling pathway.
Methods: A rat CPB model and an in vitro cell hypoxia model w
Animal StudyHighlighted
MHID-9957925PMID: 282930842017World Journal of Gastroenterology
Nai-Ying Shen, Jian-Bin Bi, Jing-Yao Zhang, Si-Min Zhang, Jing-Xian Gu, Kai Qu, et al.
AIM
To investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved.
METHODS
Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the mice received NS
Animal StudyIn VitroHighlighted
MHID-6714009PMID: 283863422017American Journal of Translational Research
Cheng Li, Lengchen Hou, Dan Chen, Fuqing Lin, Tao Chang, Mengzhu Li, et al.
Objectives: The inhaled general anesthetic isoflurane has been shown to induce caspase-3 activation in vitro and in vivo. The underlying mechanisms and functional consequences of this activity remain unclear. Isoflurane can induce caspase-3 activation by causing accumulation of reactive oxygen species (ROS), mitochondrial dysfunction, and reduction in adenosine triphosphate (ATP) levels. This stud
Mechanisms ReviewHighlighted
MHID-2497534PMID: 285968082017Experimental and Therapeutic Medicine
YIMING LIU, Jin Zhang
The pathogenesis of acute lung injury (ALI) induced by lipopolysaccharide (LPS) involves excessive pulmonary inflammation and oxidative stress. In turn, autophagy is associated with inflammatory diseases and organ dysfunction, and studies have demonstrated that LPS treatment may trigger autophagy. Thus, excessive autophagy may stimulate the strong inflammatory response observed in the development
Literature ReviewHighlighted
MHID-2847992PMID: 278264242016Medical Gas Research
Ou-yang Chen, Zhou-heng Ye, Chong Li
June 27, 2015, the Second Hydrogen Molecule Biomedical Symposium and the Second meeting of the Professional Committee of Molecular Hydrogen Biology and Medicine of China Association of Promoting International Communication of health care was grand opening in the Capital of China, Beijing, sponsored by China Association of Promoting International Communication of health care, undertaken by Professi
Animal StudyHighlighted
MHID-7644453PMID: 277741162016Oxidative Medicine and Cellular Longevity
Jiaming Guo, Deyun Zhao, Xiao Lei, Hainan Zhao, Yanyong Yang, Pei Zhang, et al.
Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H2 on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the
Animal StudyIn VitroHighlighted
MHID-8667127PMID: 277892932016Free Radical Biology and Medicine
Takafumi Ushida, Tomomi Kotani, Hiroyuki Tsuda, Kenji Imai, Tomoko Nakano, Shima Hirako, et al.
Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of preeclamps
Literature Review
MHID-0365812PMID: 282172942016Medical Gas Research
Lei Huang
Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydrox
In VitroChemical/Physicochemical StudyHighlighted
MHID-6183029PMID: 267392572016Scientific Reports
Katsuya Iuchi, Akemi Imoto, Naomi Kamimura, Kiyomi Nishimaki, Harumi Ichimiya, Takashi Yokota, et al.
We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative stress. Subsequently, numerous studies have indicated the potential applications of H2 in therapeutic and preventive medicine. Moreover, H2 regulates various signal transduction pathways and the expression of many genes. However, the primary targets of H2 in the signal transduction pathways are unknown. Her
Animal StudyIn VitroHighlighted
MHID-8944005PMID: 303740532016Scientific Reports
Yingni Lin, Bisei Ohkawara, Mikako Ito, Nobuaki Misawa, Kentaro Miyamoto, Yasuhiko Takegami, et al.
Molecular hydrogen (H2) is effective for many diseases. However, molecular bases of H2 have not been fully elucidated. Cumulative evidence indicates that H2 acts as a gaseous signal modulator. We found that H2 suppresses activated Wnt/β-catenin signaling by promoting phosphorylation and degradation οf β-catenin. Either complete inhibition of GSK3 or mutations at CK1- and GSK3-phosphorylation sites
Literature ReviewHighlighted
MHID-7479916PMID: 264839532015Medical Gas Research
Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. I
OtherHighlighted
MHID-0431541PMID: 265045152015Medical Gas Research
Ryosuke Kurokawa, Tomoki Seo, Bunpei Sato, Shin-ichi Hirano, Fumitake Sato
Molecular hydrogen (H2) is clinically administered; however, in some hospitals, H2 is given to patients without consideration of its safe use. In the present study, we prepared convenient and safe devices for the drinking of super-saturated H2 water, for intravenous drip infusion of H2-rich saline, and for the inhalation of H2 gas. In order to provide useful information for researchers using these
