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OXIDATIVE MODIFICATION OF PROTEINS IN COLORECTAL CANCER UNDER THE INFLUENCE OF 5-FLUOROURACIL AND MOLECULAR HYDROGEN

MHID-44667412024Clinical and Experimental Pathology (Клінічна та експериментальна патологія)

O. O. Pokotylo, M. M. Korda

The aim of the study – to investigate the eff ect of water saturated with molecular hydrogen and 5-fl uorouracil on the content of carbonyl groups of oxidatively modifi ed proteins in the blood serum of white rats with colorectal cancer. Material and Methods. The experiments were conducted on 50 male Wistar rats. The animals were modeled with colorectal cancer (CRC) by subcutaneous injection of 1,2-d

Systematic ReviewMeta-AnalysisHighlighted

Anti-inflammatory and antioxidant activity of high concentrations of hydrogen in the lung diseases: a systematic review and meta-analysis

MHID-4133017PMID: 392110452024Frontiers in Immunology

Kang Xiao, Jianwei Liu, Yuxin Sun, Shangya Chen, Jiazi Ma, Mao Cao, et al.

As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta- analysis. We investigated

Literature Review

New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies. The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress and its Consequences

MHID-5103861PMID: 398081702024Physiological Research

Jan Slezak, Tatiana Ravingerova, Branislav Kura

Disproportion between reactive oxygen species (ROS) production and the body's antioxidant system can cause oxidative stress, which is considered a common denominator in various pathological conditions, including cardiovascular diseases, aging, and cognitive disorders. The generation of free radicals, which occurs through partial reduction of oxygen, can quickly overwhelm the endogenous antioxidant

Animal StudyObservational StudyHighlighted

Hydrogen inhalation therapy may ameliorate amyotrophic lateral sclerosis

MHID-6966642PMID: 402326942024Medical Gas Research

Yusuke Ichikawa, Bunpei Sato, Shin-ichi Hirano, Yoshiyasu Takefuji, Fumitake Satoh

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, a neurodegenerative disorder characterized by sporadic and progressive degenerative loss of cell bodies of both the upper and lower motor neurons. Clinical manifestations of ALS are known to include lower motor neuron symptoms, upper motor neuron symptoms, bulboparesthesia symptoms, cognitive dysfunction, and negative signs. Dissociate

Literature ReviewHighlighted

The Effects of Molecular Hydrogen on Plant Physiology and Metabolism: An Overview

MHID-6653093PMID: 258736622024Journal of Plant Physiology and Metabolism

John T. Hancock

Gaseous hydrogen (H2) has emerged as a molecule that has a significant influence on the growth and development of plants, particularly if they are under stress. Often research has shown the ameliorating effects of H2 during drought, in the presence of heavy metals or salt, or during UV light irradiation. Postharvest, H2 has been shown to increase the quality of fruits and vegetables during storage

Literature Review

The Clinical Use of Hydrogen as a Medical Treatment

MHID-87403452024Molecular Hydrogen in Health and Disease

Yunbo Xie, Guohua Song

It has been demonstrated that hydrogen molecules possess biological effects, and furthermore, they are colorless, non-toxic, and have a small molecular weight, enabling them to traverse the blood–brain barrier. This review synthesizes more than 100 publications on the use of hydrogen therapy in clinical ailments and categorizes the applications of hydrogen medicine into nine major systemic disease