Opinion PieceOtherHighlighted
MHID-96353272025Frontiers in Neurology
Liu Dong-mei, Yao Jian-qiang, Ma Yan-e
Wu et al. (1) conducted a pioneering randomized controlled trial (RCT) to evaluate perioperative hydrogen inhalation in glioma patients, demonstrating a statistically significant reduction in postoperative brain edema and improved short-term neurological outcomes. While these findings highlight hydrogen’s potential as an adjuvant therapy, critical analysis from statistical and clinical perspectives
HypothesisOpinion PieceHighlighted
MHID-6155704PMID: 402510252025Medical Gas Research
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
The increasing prevalence of obesity and non-communicable diseases has become a major global health concern, contributing to significant morbidity and mortality rates. These conditions not only burden healthcare systems but also affect the individual’s quality of life worldwide. As these challenges continue to grow, there is a pressing need to explore treatment options that are effective, affordab
HypothesisOpinion PieceOtherHighlighted
MHID-0628712PMID: 356757612022Annals of Nutrition and Metabolism
Sergej M Ostojic
Molecular hydrogen (dihydrogen or hydrogen gas) is a small bioactive molecule involved in various metabolic pathways, from redox-sensitive reactions and cell signaling to bioenergetics and gut microbiota biology. Drinking hydrogen-rich water (HRW) has been suggested as a safe, novel, and promising nutritional strategy to attenuate metabolic disorders and burdensome and highly prevalent conditions
Literature ReviewOpinion PieceHighlighted
MHID-7464677PMID: 340520182022The Journal of Thoracic and Cardiovascular Surgery
John N. Kheir, MD, James A. DiNardo, MD
Diatomic hydrogen (H2) is the lightest and most abundant molecule in the universe. Hydrogen's reactivity with oxygen is well recognized as a thermodynamically favorable redox reaction that forms water. H2's small size results in unsurpassed diffusivity (even diffusing through steel), enabling it to reach therapeutic targets effectively even in low-flow states. In vivo, inhaled H2 undergoes solubil
Opinion PieceHighlighted
MHID-62678002021Canadian Journal of Physiology and Pharmacology
Shigeo Ohta, Tyler W. LeBaron
The authors of the “Discussion” (Falster et al. 2021) have responded to our article entitled: “Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study”. Hydrogen (H2) medicine is being developed as an orthodox science. In this Reply, we would like to elaborate on the effects of H2-infused water and the scientific understand
HypothesisOpinion Piece
MHID-9436520PMID: 329827932020Frontiers in Physiology
Sergej M Ostojic
Barton et al. (2018) have recently evaluated the differences in fecal microbiota between professional rugby players and healthy age-matched sedentary controls. The authors reported a rather preferential intestinal microbiome profile in physically active individuals, characterized by the greater microbial diversity and functional/metabolic activity, as evaluated by whole metagenome shotgun sequencing
Opinion Piece
MHID-94117542020Therapeutic Advances in Respiratory Disease
Sergej M Ostojic
Recent public reports by China’s National Health Commission and the Chinese Center for Disease Control and Prevention have recommended effective oxygen therapy measures as an element of general treatment in patients with novel coronavirus pneumonia (COVID-19).1,2 Both documents disclosed a rather exotic ratio of hydrogen and oxygen (66.6% H2 to 33.3% O2) as the composition of the gas mixture for i
Literature ReviewOpinion Piece
MHID-2698536PMID: 280038792016F1000Research
Sergej M Ostojic
Molecular hydrogen (H ) has recently been recognized as a potential novel therapeutic agent in biomedicine. Initially proposed to be a possible treatment for certain types of neuromuscular disorders, cardio-metabolic diseases and cancer, H improved clinical end-points and surrogate markers in several clinical trials, mainly acting as an anti-inflammatory agent and powerful antioxidant. In this pap
Opinion Piece
MHID-8567647PMID: 261233972015The Journal of Thoracic and Cardiovascular Surgery
Harold L. Lazar, MD
Patients with pulmonary arterial hypertension (PAH) are at higher risk for morbidity and mortality after all types of cardiac surgical procedures. These patients have higher incidences of hemodynamic instability, hypoxemia, and right ventricular dysfunction. Current therapy for PAH has included prostanoids, endothelial receptor antagonists, and phosphodiesterase inhibitors. Although these agents h
