Commentary: Hydrogen: Lightweight molecule takes on a heavyweight problem

Abstract

Diatomic hydrogen (H2) is the lightest and most abundant molecule in the universe. Hydrogen's reactivity with oxygen is well recognized as a thermodynamically favorable redox reaction that forms water. H2's small size results in unsurpassed diffusivity (even diffusing through steel), enabling it to reach therapeutic targets effectively even in low-flow states. In vivo, inhaled H2 undergoes solubilized transport to the tissues and undergoes redox reactions with reactive oxygen species (ROS) within the mitochondrion, resulting in a substantial arteriovenous difference in dissolved H2 content (∼10 ng/mL).

Study details

Article type

Opinion / Commentary

Disease / injury model

Spinal cord ischemia-reperfusion injury (IRI)

Dose comparison

Dose-dependent effects of hydrogen gas are emphasized, with improved outcomes at higher concentrations up to the nonflammable limit.

Dose-dependent effect

Yes

Outcome

Positive

Findings

Hydrogen gas attenuates the effects of experimental spinal ischemia and has demonstrated beneficial effects in various preclinical models of ischemia-reperfusion injury.