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Literature ReviewHighlighted

Synergistic Antioxidant Effects of Molecular Hydrogen and Cold Atmospheric Plasma in Enhancing Mesenchymal Stem Cell Therapy

MHID-1339888PMID: 397659102024Antioxidants

Mikhail Yu. Artamonov, Felix A. Pyatakovich, Inessa A. Minenko

In regenerative medicine, mesenchymal stem cells (MSCs) have shown their importance and potential in tissue reconstruction and immune system modification. However, such cells’ potential is often diminished by factors such as oxidative stress, immune rejection, and inadequate engraftment. This review highlights the role of molecular hydrogen (H2) and cold atmospheric plasma (CAP) as adjunct therapi

Mechanisms ReviewHighlighted

Mesenchymal Stem Cell Priming: Potential Benefits of Administration of Molecular Hydrogen

MHID-3162417PMID: 386754292024Pharmaceuticals

Mikhail Yu. Artamonov, Tyler W. LeBaron, Felix A. Pyatakovich, Inessa A. Minenko

Stem cell therapy has emerged as a promising avenue for regenerative medicine, offering the potential to treat a wide range of debilitating diseases and injuries. Among the various types of stem cells, mesenchymal stem cells (MSCs) have garnered significant attention due to their unique properties and therapeutic potential. In recent years, researchers have been exploring novel approaches to enhan

In VitroHighlighted

Hydrogen gas improves proliferation and mitochondrial activity of human adipose-derived stem cells after cryopreservation

MHID-5509595PMID: 392466992024Regenerative Therapy

Koji Kimura, Yasuhiko Tabata

The objective of this study is to evaluate the effect of hydrogen gas on the biological functions of human adipose-derived stem cells (hADSC) in cryopreservation. hADSC were cryopreserved by a commercial cell preservation solution in the presence of hydrogen gas. After cryopreservation at 80 C, the viability, initial attachment morphology, and biological parameters of cells cryopreserved were eval

Literature ReviewHighlighted

Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration

MHID-5381032PMID: 369788842023Antioxidants

Mikhail Yu. Artamonov, Andrew K. Martusevich, Felix A. Pyatakovich, Inessa A. Minenko, Sergei V. Dlin, Tyler W. LeBaron

It is known that molecular hydrogen is a relatively stable, ubiquitous gas that is a minor component of the atmosphere. At the same time, in recent decades molecular hydrogen has been shown to have diverse biological effects. By the end of 2022, more than 2000 articles have been published in the field of hydrogen medicine, many of which are original studies. Despite the existence of several review

In VitroPlant StudyHighlighted

H2 supplied via ammonia borane stimulates lateral root branching via phytomelatonin signaling

MHID-7645260PMID: 379440262023Plant Physiology

Yueqiao Wang, Shanshan Jin, Ziyu Liu, Genmei Chen, Pengfei Cheng, Longna Li, et al.

A reliable and stable hydrogen gas (H2) supply will benefit agricultural laboratory and field trials. Here, we assessed ammonia borane (AB), an efficient hydrogen storage material used in the energy industry, and determined its effect on plant physiology and the corresponding mechanism. Through hydroponics and pot experiments, we discovered that AB increases tomato (Solanum lycopersicum) lateral r