Animal StudyHighlighted
MHID-8967574PMID: 416411602026Frontiers in Nutrition
Eika Mizuno, Tatsuhiro Sato, Kosuke Okada, Ikuru Miura, Junichi Shoda, Makoto Saito, et al.
Introduction: Hydrogen-rich water (HRW) has been reported to reduce oxidative stress, suppress exercise fatigue, and enhance recovery. However, the molecular mechanisms of its effects on exercise capacity, especially during the early stages of adaptation in physically inactive individuals, remain unclear.
Methods: Male 8-week-old C57BL/6 J mice were provided with purified water or HRW for 1, 2, 4,
Animal StudyIn VitroHighlighted
MHID-1663779PMID: 405801852026Medical Gas Research
Yinyin Zhang, Yajing Ying, Xianpeng Zu, Lingling Ding, Xuan Shi, Jing Wang, et al.
Exercise-induced fatigue limits athletic performance. Molecular hydrogen is an effective treatment for relieving fatigue, but the exact mechanism is not clear. In our study, a mouse model of fatigue was established to explore the molecular mechanism by which hydrogen-rich water reduces exercise-induced fatigue. The results showed that hydrogen-rich water improved the motor function of fatigue mice
Clinical TrialAnimal StudyHighlighted
MHID-05612832025Sportivnaya meditsina: nauka i praktika (Sports medicine: research and practice)
Oleg S. Medvedev, Aleksey A. Uzhakov, Olga L. Konnova, Oxana V. Povarova
Purpose of the study: to investigate the effect of periodic hydrogen inhalations for one month on the main performance characteristics, lactate levels and other biochemical parameters determined in the blood of young wrestlers after physical activity.
Materials and methods. 10 healthy volunteer athletes took part in a prospective clinical study. The analysis of hydrogen and methane levels in exha
Observational Study
MHID-31585802025Sport Sciences for Health
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
Purpose Exercise induces transient physiological disruptions, including immune suppression and gastrointestinal (GI) disturbance. Molecular hydrogen (H₂), an endogenously produced gas with antioxidant and anti-inflammatory properties, may play a protective role in this context. While the therapeutic potential of exogenous H₂ has been widely explored, little is known about endogenous hydrogen respo
Clinical TrialHighlighted
MHID-96660182025Journal of Physical Education and Sport
Jakub Krejčí, Michal Botek, Shigeo Ohta, Klara Botkova, Andrew McKune
Problem Statement: Effective inter-match recovery plays a crucial role in preserving performance and preventing injuries in well-trained soccer players. In this context, molecular hydrogen has attracted increasing attention in sports science due to its selective antioxidative, anti-inflammatory, and cell-signaling properties that may facilitate recovery. Among the various administration methods, h
Clinical Trial
MHID-98854012024Science & Sports
S.H. Ryu, J.H. Oh, K.W. Noh, S. Park
Summary
Objective: This study aimed to contribute towards improving athletic performance by comparing the effects of highly concentrated hydrogen intake before and during exercise on soccer players’ metabolic and athletic performance.
Materials and methods: This study followed a single-blind crossover design involving 10 male college soccer players. Before this experiment, the Vmax measurement a
Systematic Review
MHID-7472923PMID: 382560452024International Journal of Molecular Sciences
Gagandeep Dhillon, Venkata Buddhavarapu, Harpreet Grewal, Pranjal Sharma, Ram Kishun Verma, Ripudaman Munjal, et al.
Hydrogen-rich water (HRW) has emerged as a novel approach in the field of health and wellness. It is believed to have therapeutic antioxidant properties that can neutralize harmful free radicals in the human body. It has also been shown to be beneficial in mitigating oxidative stress-induced damage through its anti-inflammatory and anti-apoptotic pathways. We aim to conduct a systematic review to
Clinical Trial
MHID-8109346PMID: 390647852024Nutrients
Gengxin Dong, Haiyan Liu, Yunji Chen, Dapeng Bao, Wentao Xu, Junhong Zhou
Background: The diversity of blood biomarkers used to assess the metabolic mechanisms of hydrogen limits a comprehensive understanding of its effects on improving exercise performance. This study evaluated the impact of hydrogen-rich gas (HRG) on metabolites following sprint-interval exercise using metabolomics approaches, aiming to elucidate its underlying mechanisms of action.
Methods: Ten heal
Clinical Trial
MHID-0740382PMID: 386986242024International Journal of Sports Medicine
Gengxin Dong, Jianxin Wu, Yinglu Hong, Qian Li, Meng Liu, Guole Jiang, et al.
Hydrogen, as an antioxidant, may have the potential to mitigate fatigue and improve selected oxidative stress markers induced by strenuous exercise. This study focused on a previously unexplored approach involving pre-exercise inhalation of hydrogen-rich gas (HRG). Twenty-four healthy adult men first completed pre-laboratories to determine maximum cycling power (Wmax) and maximum cycling time (Tma
Clinical TrialHighlighted
MHID-9198954PMID: 397039112024PeerJ
Yuqi Zhao, Chaoqun Li, Shi Zhou, Zhiguang Xu, Xin Huang, Li Wen
Background: Inhalation of hydrogen gas (H2) as an antioxidant supplement may alleviate exercise-induced oxidative damage and protect post-exercise hydrogen peroxide signaling, which may help mediate beneficial exercise adaptation. The aims of this study were to determine the effects of H2 inhalation on plasma nitric oxide (NO) level and its synthesis precursor in professional athletes.
Methods: A
Systematic ReviewMeta-Analysis
MHID-0733746PMID: 385908282024Frontiers in Nutrition
Yiting Li, Renjie Bing, Meng Liu, Zhangyuting Shang, Yan Huang, Kaixiang Zhou, et al.
Objective: Exercise-induced oxidative stress affects multiple neurophysiological processes, diminishing the exercise performance. Hydrogen (H2) can selectively reduce excessive free radicals, but studies observed its “dual effects” on exercise-induced oxidative stress, that is, increasing or decreasing the oxidative stress. Therefore, we here conducted a systematic review and meta-analysis to quan
Clinical TrialHighlighted
MHID-7865618PMID: 394347212024Frontiers in Physiology
Kaixiang Zhou, Chaoqun Yuan, Zhangyuting Shang, Wenhui Jiao, Yubo Wang
Background: Exercise-induced oxidative stress and inflammation can impair muscular function in humans. The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) highlight its potential to be as an effective nutritional supplement to support muscular function performance in healthy adults. However, the effects of H2 supplementation on muscular endurance performance in trained indivi
Literature Review
MHID-0933508PMID: 394529182024Metabolites
Qiaorui Zhou, Huixin Li, Ye Zhang, Yirui Zhao, Can Wang, Chang Liu
Background: Hydrogen-rich water (HRW) has garnered significant interest within the sports and exercise science community due to its selective antioxidant properties. Despite its potential benefits, comprehensive reviews specifically addressing its effects on athletic performance are limited. This review aims to assess the impact of HRW on sports performance and explore the underlying molecular bio
Clinical TrialHighlighted
MHID-7726015PMID: 386811432024Frontiers in Physiology
Barbora Sládečková, Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Filip Neuls, et al.
Purpose: Molecular hydrogen has been shown to possess antioxidant, anti-inflammatory, ergogenic, and recovery-enhancing effects. This study aimed to assess the effect of molecular hydrogen administration on muscle performance, damage, and perception of soreness up to 24 h of recovery after two strenuous training sessions performed on the same day in elite fin swimmers.
Methods: Eight females (mean ±
Meta-AnalysisHighlighted
MHID-3941772PMID: 368196972023Frontiers in nutrition
Kaixiang Zhou, Liu M, Wang Y, Liu H, Manor B, Bao D, et al.
Background: Fatigue is oftentimes induced by high-intensity exercise potentially via the exceeded amount of reactive oxygen species, leading to diminished functions (e.g., aerobic capacity) and increased risk of injuries. Studies indicate that molecular hydrogen (H2), with antioxidant and anti-inflammatory properties, may be a promising strategy to alleviate fatigue and improve aerobic capacity. H
Clinical Trial
MHID-8170738PMID: 381628312023Frontiers in Physiology
Nidhal Jebabli, Nejmeddine Ouerghi, Wissal Abassi, Fatma Hilal Yagin, Mariem Khlifi, Manar Boujabli, et al.
Molecular hydrogen (H2 gas) dissolved in water to produce Hydrogen-Rich Water. Hydrogen-Rich Water (HRW) is considered as ergogenic aid in different exercise modes. However, acute pre-exercise HRW ingestion effect is unclear regarding athlete performance. This study aimed at investigating acute effect of HRW ingestion on aerobic and anaerobic exercise performance. Twenty-two male amateur middle-di
Clinical TrialObservational Study
MHID-5379845PMID: 355648082022International Journal of Environmental Research and Public Health
Gengxin Dong, Jiahui Fu, Dapeng Bao, Junhong Zhou
Background: Exercise that exceeds the body’s accustomed load can lead to oxidative stress and increased fatigue during intense training or competition, resulting in decreased athletic performance and an increased risk of injury, and the new medicinal H2 may be beneficial as an antioxidant. Therefore, we explored the effect of short-term supplementation of hydrogen-rich water (HRW) on the work perfo
Clinical Trial
MHID-7655607PMID: 365385542022PLOS ONE
Michal Valenta, Michal Botek, Jakub Krejčí, Andrew McKune, Barbora Sládečková, Filip Neuls, et al.
Purpose This study investigated the effects of acute, pre-exercise, hydrogen rich water (HRW) ingestion on running time to exhaustion at maximal aerobic speed in trained track and field runners.
Methods Twenty-four, male runners aged 17.5 ± 1.8 years, with body mass index = 21.0 ± 1.3 kgm-2, and maximal oxygen uptake = 55.0 ± 4.6 mlkg-1min-1 (mean ± standard deviation) participated in this ran
Clinical TrialHighlighted
MHID-6109070PMID: 362356282022Nutrients
Ahad Abdulkarim D. Alharbi, Noriaki Iwamoto, Naoyuki Ebine, Satoshi Nakae, Tatsuya Hojo, Yoshiyuki Fukuoka
This research examined the effects of single-dose molecular hydrogen (H2) supplements on acid-base status and local muscle deoxygenation during rest, high-intensity intermittent training (HIIT) performance, and recovery. Ten healthy, trained subjects in a randomized, double-blind, crossover design received H2-rich calcium powder (HCP) (1500 mg, containing 2.544 µg of H2) or H2-depleted placebo (15
Clinical Trial
MHID-7556506PMID: 352768672022Nutrients
Michal Botek, Deepesh Khanna, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, et al.
Hydrogen-rich water (HRW) supplementation has been shown to have an antifatigue effect across different modes of exercise. However, its effect on repeated sprint performance is unknown. The aim of this study was to assess the effect of pre-exercise HRW consumption on repeated sprint performance, lactate, and perceptual responses using a repeated sprint protocol. This randomized, double blinded, pl
