Clinical TrialHighlighted
MHID-96660182025Journal of Physical Education and Sport
Jakub Krejčí, Michal Botek, Shigeo Ohta, Klara Botkova, Andrew McKune
Problem Statement: Effective inter-match recovery plays a crucial role in preserving performance and preventing injuries in well-trained soccer players. In this context, molecular hydrogen has attracted increasing attention in sports science due to its selective antioxidative, anti-inflammatory, and cell-signaling properties that may facilitate recovery. Among the various administration methods, h
Observational StudyHighlighted
MHID-2151796PMID: 399341432025Scientific Reports
Masaaki Nakayama, Kimio Watanabe, Emiko Sato, Yugo Ito, Nozomi Kadota, Kasumi Konishi, et al.
Hemodialysis employing molecular hydrogen (H2)-enriched dialysis solution rendered by water electrolysis (E-HD), has been reported to alleviate dialysis-related fatigue, but its association with metabolic profiles remains unclear. Eighty-one patients undergoing standard HD were classified into 3 groups [Group A (n = 25, 30.9%): fatigue with activity reduction—subgroups A1: chronic persistent fatig
Clinical Trial
MHID-8109346PMID: 390647852024Nutrients
Gengxin Dong, Haiyan Liu, Yunji Chen, Dapeng Bao, Wentao Xu, Junhong Zhou
Background: The diversity of blood biomarkers used to assess the metabolic mechanisms of hydrogen limits a comprehensive understanding of its effects on improving exercise performance. This study evaluated the impact of hydrogen-rich gas (HRG) on metabolites following sprint-interval exercise using metabolomics approaches, aiming to elucidate its underlying mechanisms of action.
Methods: Ten heal
Clinical Trial
MHID-0740382PMID: 386986242024International Journal of Sports Medicine
Gengxin Dong, Jianxin Wu, Yinglu Hong, Qian Li, Meng Liu, Guole Jiang, et al.
Hydrogen, as an antioxidant, may have the potential to mitigate fatigue and improve selected oxidative stress markers induced by strenuous exercise. This study focused on a previously unexplored approach involving pre-exercise inhalation of hydrogen-rich gas (HRG). Twenty-four healthy adult men first completed pre-laboratories to determine maximum cycling power (Wmax) and maximum cycling time (Tma
Observational Study
MHID-3841687PMID: 379295122024Medical Gas Research
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue and malaise that persist for more than 6 months with neuropsychiatric symptoms, including slight fever, headache, weakness, impaired thinking, and depression. The onset and severity of these symptoms vary and reduce the quality of life as well as social, occupational, and personal activities of thos
Clinical TrialHighlighted
MHID-7865618PMID: 394347212024Frontiers in Physiology
Kaixiang Zhou, Chaoqun Yuan, Zhangyuting Shang, Wenhui Jiao, Yubo Wang
Background: Exercise-induced oxidative stress and inflammation can impair muscular function in humans. The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) highlight its potential to be as an effective nutritional supplement to support muscular function performance in healthy adults. However, the effects of H2 supplementation on muscular endurance performance in trained indivi
Meta-AnalysisHighlighted
MHID-3941772PMID: 368196972023Frontiers in nutrition
Kaixiang Zhou, Liu M, Wang Y, Liu H, Manor B, Bao D, et al.
Background: Fatigue is oftentimes induced by high-intensity exercise potentially via the exceeded amount of reactive oxygen species, leading to diminished functions (e.g., aerobic capacity) and increased risk of injuries. Studies indicate that molecular hydrogen (H2), with antioxidant and anti-inflammatory properties, may be a promising strategy to alleviate fatigue and improve aerobic capacity. H
Clinical TrialObservational Study
MHID-5379845PMID: 355648082022International Journal of Environmental Research and Public Health
Gengxin Dong, Jiahui Fu, Dapeng Bao, Junhong Zhou
Background: Exercise that exceeds the body’s accustomed load can lead to oxidative stress and increased fatigue during intense training or competition, resulting in decreased athletic performance and an increased risk of injury, and the new medicinal H2 may be beneficial as an antioxidant. Therefore, we explored the effect of short-term supplementation of hydrogen-rich water (HRW) on the work perfo
Literature Review
MHID-5798437PMID: 354938142022Frontiers in Neurology
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disorder that is characterized by fatigue that persists for more than 6 months, weakness, sleep disturbances, and cognitive dysfunction. There are multiple possible etiologies for ME/CFS, among which mitochondrial dysfunction plays a major role in abnormal energy metabolism. The potential of many substances for the treatment of ME/CF
Clinical Trial
MHID-7556506PMID: 352768672022Nutrients
Michal Botek, Deepesh Khanna, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, et al.
Hydrogen-rich water (HRW) supplementation has been shown to have an antifatigue effect across different modes of exercise. However, its effect on repeated sprint performance is unknown. The aim of this study was to assess the effect of pre-exercise HRW consumption on repeated sprint performance, lactate, and perceptual responses using a repeated sprint protocol. This randomized, double blinded, pl
Observational Study
MHID-22983482022Renal Replacement Therapy
Susumu Uemura, Yoshitaka Kegasa, Keigo Tada, Taichi Tsukahara, Shigeru Kabayama, Tae Yamamoto, et al.
Background: Reportedly, dialysis solutions containing molecular hydrogen (H2) might ameliorate patient-reported fatigue in hemodialysis (HD) patients. However, it is unknown whether its impact might differ with different H2 levels.
Method: This single-arm, prospective observational study examined 105 patients on chronic HD (62 males; mean age, 66 years; mean HD duration, 117 months). All patients
Clinical TrialHighlighted
MHID-5245813PMID: 352061792022International Journal of Environmental Research and Public Health
Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, Petr Konečný, et al.
Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties. The aim of this study was to determine the effect of 14 days of H2 inhalation on the respiratory and physical fitness status of acute post-COVID-19 patients. This randomized, single-blin
Clinical TrialHighlighted
MHID-0754862PMID: 361246532022American Journal of Clinical Nutrition
Xiang Lv, Yuanfeng Lu, Guoyong Ding, Xiao Li, Xinxin Xu, Aihua Zhang, et al.
Background: Alcohol-induced hangover represents a significant, yet understudied, global hazard and a large socioeconomic burden. Objective: The aim of this study was to investigate the effects of hydrogen on relieving drinking and hangover symptoms in 20 healthy volunteers.
Methods: In this pilot, randomized, double-blinded, placebo- controlled, matched, crossover interventional trial, participan
Clinical TrialHighlighted
MHID-82748422022Processes
Mihyun Lee, Ailyn Fadriquela, Jayson M. Antonio, Cheol-Su Kim, Il-Young Cho, Ka-Eun Kim, et al.
Regular physical activity confers health benefits and improves the general quality of life. Recently, alkaline-reduced water (ARW) consumption has garnered increasing attention in the field of sports. ARW effectively inhibits the oxidative stress generated in cells during high-intensity exercises; however, whether it exerts similar effects during exhaustive exercises remains unknown. This study was
Observational Study
MHID-82694502021Renal Replacement Therapy
Hidehisa Satta, Tamio Iwamoto, Yuki Kawai, Naoaki Koguchi, Kazuhiko Shibata, Nobuteru Kobayashi, et al.
Background: A novel hemodialysis (HD) system employing electrolyzed water containing molecular hydrogen (E-HD) has been developed to improve the bio-compatibility of HD. This study examined the impact of E-HD on changes in redox state during HD and HD-related fatigue.
Method: This single-arm, prospective observational study examined 63 patients on chronic HD (41 males; mean age, 72 ± 9 years; med
Observational StudyHighlighted
MHID-16201432021Renal Replacement Therapy
Yoshihiro Tsujimoto, Daisuke Kuratsune, Shigeru Kabayama, Mariko Miyazaki, Yasuyoshi Watanabe, Yoshiki Nishizawa, et al.
Background: Enhanced oxidative stress is involved with fatigue in hemodialysis (HD) patients. Molecular hydrogen (H2) could improve the redox status. Thus, the study examines whether HD solution rendered by electrolyzed water containing H2 (E-HD) could impact the fatigue and autonomic balance of patients.
Methods: This single-arm, prospective observational study examined 95 patients on chronic HD
Literature Review
MHID-3461972PMID: 309702152019Canadian Journal of Physiology and Pharmacology
Tyler W. LeBaron, Ismail Laher, Branislav Kura, Jan Slezak
H2 has been clinically demonstrated to provide antioxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic high-intensity exercise in elite athletes, or sporadic bouts of exercise (i.e. noxious exercise) in unt
Clinical Trial
MHID-2512221PMID: 315745442019International Journal of Sports Medicine
Michal Botek, Jakub Krejčí, Andrew J. McKune, Barbora Sládečková, Nenad Naumovski
The potential anti-fatigue and performance benefits of hydrogen rich water (HRW) have resulted in increased research interest over the past 5 years. The aim of this study was to assess physiological and perceptual responses to an incremental exercise protocol after administration of 600 ml HRW within 30 min before exercise. This randomized, double blinded placebo-controlled cross over study includ
