In SilicoHighlightedMolecular Hydrogen as an Antioxidant and Radioprotector: Mechanistic Insights from Monte Carlo Radiation-Chemical SimulationsMHID-6447318PMID: 410089612025AntioxidantsSumaiya Akhter Ria, Jintana Meesungnoen, Jean-Paul Jay-Gerin(1) Background: Water, comprising about 70–80% of cellular mass, is the most abundant constituent of living cells. Upon exposure to ionizing radiation, water undergoes radiolysis, generating a variety of reactive species, including free radicals and molecular products. Among these, hydroxyl radicals (•OH) are particularly damaging due to their very high reactivity and their capacity to induce oxid
Chemical/Physicochemical StudyONOOH does not react with H2: Potential beneficial effects of H2 as an antioxidant by selective reaction with hydroxyl radicals and peroxynitriteMHID-6682168PMID: 250864382014Free Radical Biology and MedicineJelle Penders, Reinhard Kissner, Willem H. KoppenolH2 has been suggested to act as an antioxidant when administered just before the reperfusion phase of induced oxidative stress. These effects have been reported, for example, for the heart, brain, and liver. It is hypothesized that this beneficial effect may be due to selective scavenging of HO⋅ and ONOOH by H2. The reaction of H2 with HO⋅ has been studied by pulse radiolysis in the past and is too
HypothesisHighlightedA possible prevention strategy of radiation pneumonitis: Combine radiotherapy with aerosol inhalation of hydrogen-rich solutionMHID-49572952011Medical Science MonitorYunhai Chuai, Luqian Zhao, Jin Ni, Ding Sun, Jianguo Cui, Bailong Li, et al.Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ioniz
