A possible prevention strategy of radiation pneumonitis: Combine radiotherapy with aerosol inhalation of hydrogen-rich solution

Abstract

Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, we hypothesize that a treatment combining radiotherapy with aerosol inhalation of a hydrogen-rich solution may be an effective and novel prevention strategy for radiation pneumonitis (hydrogen is explosive, while a hydrogen-rich solution such as physiological saline saturated with molecular hydrogen is safer).

Study details

Article type

Hypothesis

Disease / injury model

Radiation pneumonitis (as a complication of radiotherapy for thoracic/chest wall malignancies)

Dose-dependent effect

No

Outcome

Positive

Findings

The article hypothesizes that combining radiotherapy with aerosol inhalation of hydrogen-rich solution may be a safe and effective strategy to prevent radiation pneumonitis, based on hydrogen's selective antioxidant properties and previous evidence of radioprotective effects in vitro and in vivo.